AC T04256
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ID T04256
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DT 26.01.2001 (created); rio.
DT 07.04.2010 (updated); jig.
CO Copyright (C), QIAGEN.
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FA NKX3A
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SY Nkx-3.1; NKX3A.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004566 Nkx3-1.
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HO NK-3 T02665 (Drosophila).
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CL C0006; homeo; 3.1.2.16.1.
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SF 77% homeo domain homology to NK-3/Bagpipe T02665 of Drosophila [2];
SF expression level decreases markedly after castration suggesting its expression is androgen-dependent [2];
SF interacts with SRF and the homeodomain region of NKX3A facilitates SRF binding to the complex NKE-SRF [1];
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CP prostate epithelium - all stages of differentiation in vivo [3].
EX brain,,,adult; none; Northern blot; RNA (undefined); [2].
EX heart,,,adult; none; Northern blot; RNA (undefined); [2].
EX liver,,,adult; none; Northern blot; RNA (undefined); [2].
EX ovary,,,adult; none; Northern blot; RNA (undefined); [2].
EX prostate gland,,,adult; medium; Northern blot; RNA (undefined); [2].
EX prostate gland,exocrine glandulocyte,,adult; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX prostate gland,stromal cell,,adult; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX prostatic region,epithelial cell,,Theiler Stage 27; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX testis (right and left),,,adult; none; Northern blot; RNA (undefined); [2].
EX urethral epithelium,epithelial cell,,Theiler Stage 27; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2].
EX uterus,,,adult; none; Northern blot; RNA (undefined); [2].
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FF plays a role in prostate development and maintenance of the differentiated state of prostatic epithelial cells [2] [3];
FF the C terminus of NKX3A contains a transcriptional repressor domain [1];
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IN T00764 SRF; human, Homo sapiens.
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MX M02782 V$NKX31_02.
MX M00451 V$NKX3A_01.
MX M01383 V$NKX3A_02.
MX M03833 V$NKX3A_Q3.
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DR TRANSPATH: MO000028122.
DR TRANSCOMPEL: C00423.
DR UniProtKB: P97436;
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RN [1]; RE0015521.
RX PUBMED: 10993896.
RA Carson J. A., Fillmore R. A., Schwartz R. J., Zimmer W. E.
RT The smooth muscle gamma -actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor
RL J. Biol. Chem. 275:39061-39072 (2000).
RN [2]; RE0015664.
RX PUBMED: 8943214.
RA Bieberich C. J., Fujita K., He W. W., Jay G.
RT Prostate-specific and androgen-dependent expression of a novel homeobox gene
RL J. Biol. Chem. 271:31779-31782 (1996).
RN [3]; RE0024317.
RX PUBMED: 10215624.
RA Bhatia-Gaur R., Donjacour A. A., Sciavolino P. J., Kim M., Desai N., Young P., Norton C. R., Gridley T., Cardiff R. D., Cunha G. R., Abate-Shen C., Shen M. M.
RT Roles for Nkx3.1 in prostate development and cancer.
RL Genes Dev. 13:966-977 (1999).
RN [4]; RE0066439.
RX PUBMED: 19741607.
RA Wang X., Kruithof-de Julio M., Economides K. D., Walker D., Yu H., Halili M. V., Hu Y. P., Price S. M., Abate-Shen C., Shen M. M.
RT A luminal epithelial stem cell that is a cell of origin for prostate cancer.
RL Nature 461:495-500 (2009).
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