TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04256 XX ID T04256 XX DT 26.01.2001 (created); rio. DT 07.04.2010 (updated); jig. CO Copyright (C), QIAGEN. XX FA NKX3A XX SY Nkx-3.1; NKX3A. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G004566 Nkx3-1. XX HO NK-3 T02665 (Drosophila). XX CL C0006; homeo; XX SF 77% homeo domain homology to NK-3/Bagpipe T02665 of Drosophila [2]; SF expression level decreases markedly after castration suggesting its expression is androgen-dependent [2]; SF interacts with SRF and the homeodomain region of NKX3A facilitates SRF binding to the complex NKE-SRF [1]; XX CP prostate epithelium - all stages of differentiation in vivo [3]. EX brain,,,adult; none; Northern blot; RNA (undefined); [2]. EX heart,,,adult; none; Northern blot; RNA (undefined); [2]. EX liver,,,adult; none; Northern blot; RNA (undefined); [2]. EX ovary,,,adult; none; Northern blot; RNA (undefined); [2]. EX prostate gland,,,adult; medium; Northern blot; RNA (undefined); [2]. EX prostate gland,exocrine glandulocyte,,adult; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2]. EX prostate gland,stromal cell,,adult; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2]. EX prostatic region,epithelial cell,,Theiler Stage 27; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2]. EX testis (right and left),,,adult; none; Northern blot; RNA (undefined); [2]. EX urethral epithelium,epithelial cell,,Theiler Stage 27; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [2]. EX uterus,,,adult; none; Northern blot; RNA (undefined); [2]. XX FF plays a role in prostate development and maintenance of the differentiated state of prostatic epithelial cells [2] [3]; FF the C terminus of NKX3A contains a transcriptional repressor domain [1]; XX IN T00764 SRF; human, Homo sapiens. XX MX M02782 V$NKX31_02. MX M00451 V$NKX3A_01. MX M01383 V$NKX3A_02. MX M03833 V$NKX3A_Q3. XX DR TRANSPATH: MO000028122. DR TRANSCOMPEL: C00423. DR UniProtKB: P97436; XX RN [1]; RE0015521. RX PUBMED: 10993896. RA Carson J. A., Fillmore R. A., Schwartz R. J., Zimmer W. E. RT The smooth muscle gamma -actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor RL J. Biol. Chem. 275:39061-39072 (2000). RN [2]; RE0015664. RX PUBMED: 8943214. RA Bieberich C. J., Fujita K., He W. W., Jay G. RT Prostate-specific and androgen-dependent expression of a novel homeobox gene RL J. Biol. Chem. 271:31779-31782 (1996). RN [3]; RE0024317. RX PUBMED: 10215624. RA Bhatia-Gaur R., Donjacour A. A., Sciavolino P. J., Kim M., Desai N., Young P., Norton C. R., Gridley T., Cardiff R. D., Cunha G. R., Abate-Shen C., Shen M. M. RT Roles for Nkx3.1 in prostate development and cancer. RL Genes Dev. 13:966-977 (1999). RN [4]; RE0066439. RX PUBMED: 19741607. RA Wang X., Kruithof-de Julio M., Economides K. D., Walker D., Yu H., Halili M. V., Hu Y. P., Price S. M., Abate-Shen C., Shen M. M. RT A luminal epithelial stem cell that is a cell of origin for prostate cancer. RL Nature 461:495-500 (2009). XX //