AC T02066
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ID T02066
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DT 28.01.1997 (created); hiwi.
DT 25.04.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Fli-1
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SY Erg-B; friend leukemia integration site 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G007339 FLI1; HGNC: FLI1.
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CL C0016; ETS; 3.5.2.1.5.
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SF there may be splice variants (Fli-1a and -1b) [5];
SF the ETS domain comprises three alpha-helices and a four-stranded antiparallel beta-sheet, similar to the helix-turn-helix region of bacterial CAP [9];
SF chromosomal t(11;
SF 22) translocations fuse the C-terminus encoding part of Fli-1 to the N-terminal coding part and the promoter of the EWS (Ewings sarcoma) gene [3];
SF this promoter provides widespread or ubiquitous rather than tissue-restricted expression of the Fli-1 trans-activation domain [3];
SF N-terminal part of Fli-1 probably contains autorepression domain [10];
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CP high levels in lymphocytes, thymus; very low in ovary, bone marrow, heart, spleen; Ramos, BL2, E418, IARC-EW17, Jurkat [11]; Dami, UT-7/TPO [13].
CN liver, lung pancreas [2]; Saos, HeLa, K562 [11] [11] [2]; K562, UT-7/EPO Mpl [13].
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FF TPO-inducible in UT-7/TPO cells [13];
FF activator [2] [6];
FF the chimeric EWS-Fli1 protein is an even stronger activator [6] [7];
FF EWS-Fli1, but not wt Fli-1 forms ternary complexes with SRF and c-fos promoter [10];
FF Fli-1 interacts with SRF in solution [10];
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IN T08587 c-Jun; mouse, Mus musculus.
IN T08590 JunB; mouse, Mus musculus.
IN T08536 JunD; mouse, Mus musculus.
IN T25624 p/CAF; human, Homo sapiens.
IN T00764 SRF; human, Homo sapiens.
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MX M08881 V$ETSLIKE_Q4.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
MX M02073 V$FLI1_02.
MX M03988 V$FLI1_03.
MX M03989 V$FLI1_04.
MX M07089 V$FLI1_05.
MX M08913 V$FLI1_06.
MX M07382 V$FLI1_Q5.
MX M01208 V$FLI1_Q6.
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BS R02386.
BS R26234.
BS R25964.
BS R15106.
BS R64846.
BS R64850.
BS R26656.
BS R73629.
BS R21052.
BS R25722.
BS R60985.
BS R25528.
BS R25529.
BS R31564.
BS R37217.
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DR TRANSPATH: MO000005191.
DR TRANSCOMPEL: C00612.
DR UniProtKB: Q01543; FLI1_HUMAN.
DR PDB: 1FLI.
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RN [1]; RE0005316.
RX PUBMED: 8223245.
RA Klaembt C.
RT The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells
RL Development 117:163-176 (1993).
RN [2]; RE0005341.
RX PUBMED: 1445800.
RA Watson D. K., Smyth F. E., Thompson D. M., Cheng J. Q., Testa J. R., Papas T. S., Seth A.
RT The ERGB/Fli-1 gene: Isolation and characterization of a new member of the family of human ETS transcription factors
RL Cell Growth Differ. 3:705-713 (1992).
RN [3]; RE0005342.
RX PUBMED: 1522903.
RA Delattre O., Zucman J., Plougastel B., Desmaze C., Melot T., Peter M., Kovar H., Joubert I., de Jong P., Rouleau G.
RT Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
RL Nature 359:162-165 (1992).
RN [4]; RE0005344.
RX PUBMED: 8439553.
RA Hromas R. A., Mau W., Denny C., Raskind W., Moore J., Maki R. A., Beck E., Klemsz M. J.
RT Human FLI-1 localizes to chromosome 11Q24 and has an aberrant transcript in neureopethelioma
RL Biochim. Biophys. Acta 1172:155-158 (1993).
RN [5]; RE0005345.
RX PUBMED: 1394211.
RA Prasad D. D. K., Rao V. N., Reddy E. S. P.
RT Structure and expression of human Fli-1 gene
RL Cancer Res. 52:5833-5837 (1992).
RN [6]; RE0005346.
RX PUBMED: 8336942.
RA Rao V. N., Ohno T., Prasad D. D. K., Battacharya G., Reddy E. S. P.
RT Analysis of the DNA binding and transcriptional activation functions of human Fli-1 protein
RL Oncogene 8:2167-2173 (1993).
RN [7]; RE0005347.
RX PUBMED: 7503813.
RA Ohno T., Rao V. N., Reddy E. S. P.
RT EWS/Fli-1 chimeric protein is a transcriptional activator
RL Cancer Res. 53:5859-5863 (1993).
RN [8]; RE0005348.
RX PUBMED: 8516324.
RA May W. A., Gishizky M. L., Lessnick S. L., Lunsford L. B., Lewis B. C., Delattre O., Zucman J., Thomas G., Denny X. C. T.
RT Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation
RL Proc. Natl. Acad. Sci. USA 90:5752-5756 (1993).
RN [9]; RE0005349.
RX PUBMED: 7972119.
RA Liang H., Olejniczak E. T., Mao X., Nettesheim D. G., Yu L., Thompson C. B., Fesik S. W.
RT The secondary structure of the ets domain of human Fli-1 resembles that of the helix-turn-helix DNA-binding motif of the Escherichia coli catabolite gene activator protein
RL Proc. Natl. Acad. Sci. USA 91:11655-11659 (1994).
RN [10]; RE0015489.
RX PUBMED: 8604338.
RA Magnaghi-Jaulin L., Masutani H., Robin P., Lipinski M., Harel-Bellan A.
RT SRE elements are binding sites for the fusion protein EWS-FLI-1
RL Nucleic Acids Res. 24:1052-1058 (1996).
RN [11]; RE0015517.
RX PUBMED: 8764983.
RA Magnaghi-Jaulin L., Masutani H., Lipinski M., Harel-Bellan A.
RT Analysis of SRF, SAP-1 and ELK-1 transcripts and proteins in human cell lines
RL FEBS Lett. 391:247-251 (1996).
RN [12]; RE0016689.
RX PUBMED: 7648395.
RA Bassuk A. G., Leiden J. M.
RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
RL Immunity 3:223-237 (1995).
RN [13]; RE0046278.
RX PUBMED: 12359731.
RA Holmes M. L., Bartle N., Eisbacher M., Chong B. H.
RT Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1
RL J. Biol. Chem. 277:48333-41 (2002).
RN [14]; RE0048258.
RX PUBMED: 12743594.
RA Pei H., Yordy J. S., Leng Q., Zhao Q., Watson D. K., Li R.
RT EAPII interacts with ETS1 and modulates its transcriptional function.
RL Oncogene 22:2699-2709 (2003).
RN [15]; RE0071919.
RX PUBMED: 19158279.
RA Asano Y., Trojanowska M.
RT Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta.
RL Mol. Cell. Biol. 29:1882-1894 (2009).
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