TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02066 XX ID T02066 XX DT 28.01.1997 (created); hiwi. DT 25.04.2016 (updated); mkl. CO Copyright (C), QIAGEN. XX FA Fli-1 XX SY Erg-B; friend leukemia integration site 1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G007339 FLI1; HGNC: FLI1. XX CL C0016; ETS; XX SF there may be splice variants (Fli-1a and -1b) [5]; SF the ETS domain comprises three alpha-helices and a four-stranded antiparallel beta-sheet, similar to the helix-turn-helix region of bacterial CAP [9]; SF chromosomal t(11; SF 22) translocations fuse the C-terminus encoding part of Fli-1 to the N-terminal coding part and the promoter of the EWS (Ewings sarcoma) gene [3]; SF this promoter provides widespread or ubiquitous rather than tissue-restricted expression of the Fli-1 trans-activation domain [3]; SF N-terminal part of Fli-1 probably contains autorepression domain [10]; XX CP high levels in lymphocytes, thymus; very low in ovary, bone marrow, heart, spleen; Ramos, BL2, E418, IARC-EW17, Jurkat [11]; Dami, UT-7/TPO [13]. CN liver, lung pancreas [2]; Saos, HeLa, K562 [11] [11] [2]; K562, UT-7/EPO Mpl [13]. XX FF TPO-inducible in UT-7/TPO cells [13]; FF activator [2] [6]; FF the chimeric EWS-Fli1 protein is an even stronger activator [6] [7]; FF EWS-Fli1, but not wt Fli-1 forms ternary complexes with SRF and c-fos promoter [10]; FF Fli-1 interacts with SRF in solution [10]; XX IN T08587 c-Jun; mouse, Mus musculus. IN T08590 JunB; mouse, Mus musculus. IN T08536 JunD; mouse, Mus musculus. IN T25624 p/CAF; human, Homo sapiens. IN T00764 SRF; human, Homo sapiens. XX MX M08881 V$ETSLIKE_Q4. MX M00771 V$ETS_Q4. MX M00971 V$ETS_Q6. MX M02073 V$FLI1_02. MX M03988 V$FLI1_03. MX M03989 V$FLI1_04. MX M07089 V$FLI1_05. MX M08913 V$FLI1_06. MX M07382 V$FLI1_Q5. MX M01208 V$FLI1_Q6. XX BS R02386. BS R26234. BS R25964. BS R15106. BS R64846. BS R64850. BS R26656. BS R73629. BS R21052. BS R25722. BS R60985. BS R25528. BS R25529. BS R31564. BS R37217. XX DR TRANSPATH: MO000005191. DR TRANSCOMPEL: C00612. DR UniProtKB: Q01543; FLI1_HUMAN. DR PDB: 1FLI. XX RN [1]; RE0005316. RX PUBMED: 8223245. RA Klaembt C. RT The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells RL Development 117:163-176 (1993). RN [2]; RE0005341. RX PUBMED: 1445800. RA Watson D. K., Smyth F. E., Thompson D. M., Cheng J. Q., Testa J. R., Papas T. S., Seth A. RT The ERGB/Fli-1 gene: Isolation and characterization of a new member of the family of human ETS transcription factors RL Cell Growth Differ. 3:705-713 (1992). RN [3]; RE0005342. RX PUBMED: 1522903. RA Delattre O., Zucman J., Plougastel B., Desmaze C., Melot T., Peter M., Kovar H., Joubert I., de Jong P., Rouleau G. RT Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours RL Nature 359:162-165 (1992). RN [4]; RE0005344. RX PUBMED: 8439553. RA Hromas R. A., Mau W., Denny C., Raskind W., Moore J., Maki R. A., Beck E., Klemsz M. J. RT Human FLI-1 localizes to chromosome 11Q24 and has an aberrant transcript in neureopethelioma RL Biochim. Biophys. Acta 1172:155-158 (1993). RN [5]; RE0005345. RX PUBMED: 1394211. RA Prasad D. D. K., Rao V. N., Reddy E. S. P. RT Structure and expression of human Fli-1 gene RL Cancer Res. 52:5833-5837 (1992). RN [6]; RE0005346. RX PUBMED: 8336942. RA Rao V. N., Ohno T., Prasad D. D. K., Battacharya G., Reddy E. S. P. RT Analysis of the DNA binding and transcriptional activation functions of human Fli-1 protein RL Oncogene 8:2167-2173 (1993). RN [7]; RE0005347. RX PUBMED: 7503813. RA Ohno T., Rao V. N., Reddy E. S. P. RT EWS/Fli-1 chimeric protein is a transcriptional activator RL Cancer Res. 53:5859-5863 (1993). RN [8]; RE0005348. RX PUBMED: 8516324. RA May W. A., Gishizky M. L., Lessnick S. L., Lunsford L. B., Lewis B. C., Delattre O., Zucman J., Thomas G., Denny X. C. T. RT Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation RL Proc. Natl. Acad. Sci. USA 90:5752-5756 (1993). RN [9]; RE0005349. RX PUBMED: 7972119. RA Liang H., Olejniczak E. T., Mao X., Nettesheim D. G., Yu L., Thompson C. B., Fesik S. W. RT The secondary structure of the ets domain of human Fli-1 resembles that of the helix-turn-helix DNA-binding motif of the Escherichia coli catabolite gene activator protein RL Proc. Natl. Acad. Sci. USA 91:11655-11659 (1994). RN [10]; RE0015489. RX PUBMED: 8604338. RA Magnaghi-Jaulin L., Masutani H., Robin P., Lipinski M., Harel-Bellan A. RT SRE elements are binding sites for the fusion protein EWS-FLI-1 RL Nucleic Acids Res. 24:1052-1058 (1996). RN [11]; RE0015517. RX PUBMED: 8764983. RA Magnaghi-Jaulin L., Masutani H., Lipinski M., Harel-Bellan A. RT Analysis of SRF, SAP-1 and ELK-1 transcripts and proteins in human cell lines RL FEBS Lett. 391:247-251 (1996). RN [12]; RE0016689. RX PUBMED: 7648395. RA Bassuk A. G., Leiden J. M. RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells. RL Immunity 3:223-237 (1995). RN [13]; RE0046278. RX PUBMED: 12359731. RA Holmes M. L., Bartle N., Eisbacher M., Chong B. H. RT Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1 RL J. Biol. Chem. 277:48333-41 (2002). RN [14]; RE0048258. RX PUBMED: 12743594. RA Pei H., Yordy J. S., Leng Q., Zhao Q., Watson D. K., Li R. RT EAPII interacts with ETS1 and modulates its transcriptional function. RL Oncogene 22:2699-2709 (2003). RN [15]; RE0071919. RX PUBMED: 19158279. RA Asano Y., Trojanowska M. RT Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta. RL Mol. Cell. Biol. 29:1882-1894 (2009). XX //