TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02725 XX ID T02725 XX DT 27.05.1999 (created); vma. DT 23.12.2014 (updated); pos. CO Copyright (C), QIAGEN. XX FA cdk9 XX SY C-2k; CDC2L4; CDK9; CTK1; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; TAK. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004707 CDK9; HGNC: CDK9. XX SF subunit of P-TEFb T02731; SF almost all cdk9 from HeLa nuclear extract is either associated with cyclin T1 or cyclin T2 [2]; SF a component of preinitiation and elongation complexes [3]; XX CP ubiquitous (heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas) [1] [2]. XX FF in vitro cell cycle-independent phosphorylation of RBp56 and MBP, but not histone H1 [1]; FF in presence of either cyclin T1, T2a or T2b phosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II and stimulation of transcriptional elongation [2]; XX IN T02727 cyclinT1; human, Homo sapiens. IN T02732 cyclinT1; mouse, Mus musculus. IN T02728 cyclinT2a; human, Homo sapiens. IN T02729 cyclinT2b; human, Homo sapiens. IN T09925 GATA-3; human, Homo sapiens. IN T00992 Hsp90; human, Homo sapiens. IN T04151 SRCAP; human, Homo sapiens. IN T02168 TFIIF-alpha; human, Homo sapiens. XX DR TRANSPATH: MO000026701. DR UniProtKB: P50750; XX RN [1]; RE0013610. RX PUBMED: 8170997. RA Grana X., de Luca A., Sang N., Fu Y., Claudio P. P., Rosenblatt J., Morgan D. O., Giordano A. RT PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. RL Proc. Natl. Acad. Sci. USA 91:3834-3838 (1994). RN [2]; RE0013612. RX PUBMED: 9499409. RA Peng J., Zhu Y., Milton J. T., Price D. H. RT Identification of multiple cyclin subunits of human P-TEFb. RL Genes Dev. 12:755-762 (1998). RN [3]; RE0013617. RX PUBMED: 10066804. RA Ping Y. H., Rana T. M. RT Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes. RL J. Biol. Chem. 274:7399-7404 (1999). RN [4]; RE0048096. RX PUBMED: 15107825. RA Cabart P., Chew H. K., Murphy S. RT BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II. RL Oncogene 23:5316-5329 (2004). RN [5]; RE0055178. RX PUBMED: 18362169. RA Nowak D. E., Tian B., Jamaluddin M., Boldogh I., Vergara L. A., Choudhary S., Brasier A. R. RT RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes. RL Mol. Cell. Biol. 28:3623-3638 (2008). XX //