AC T02725
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ID T02725
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DT 27.05.1999 (created); vma.
DT 23.12.2014 (updated); pos.
CO Copyright (C), QIAGEN.
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FA cdk9
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SY C-2k; CDC2L4; CDK9; CTK1; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); PITALRE; RP11-228B15.5; TAK.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004707 CDK9; HGNC: CDK9.
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SF subunit of P-TEFb T02731;
SF almost all cdk9 from HeLa nuclear extract is either associated with cyclin T1 or cyclin T2 [2];
SF a component of preinitiation and elongation complexes [3];
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CP ubiquitous (heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas) [1] [2].
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FF in vitro cell cycle-independent phosphorylation of RBp56 and MBP, but not histone H1 [1];
FF in presence of either cyclin T1, T2a or T2b phosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II and stimulation of transcriptional elongation [2];
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IN T02727 cyclinT1; human, Homo sapiens.
IN T02732 cyclinT1; mouse, Mus musculus.
IN T02728 cyclinT2a; human, Homo sapiens.
IN T02729 cyclinT2b; human, Homo sapiens.
IN T09925 GATA-3; human, Homo sapiens.
IN T00992 Hsp90; human, Homo sapiens.
IN T04151 SRCAP; human, Homo sapiens.
IN T02168 TFIIF-alpha; human, Homo sapiens.
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DR TRANSPATH: MO000026701.
DR UniProtKB: P50750;
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RN [1]; RE0013610.
RX PUBMED: 8170997.
RA Grana X., de Luca A., Sang N., Fu Y., Claudio P. P., Rosenblatt J., Morgan D. O., Giordano A.
RT PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro.
RL Proc. Natl. Acad. Sci. USA 91:3834-3838 (1994).
RN [2]; RE0013612.
RX PUBMED: 9499409.
RA Peng J., Zhu Y., Milton J. T., Price D. H.
RT Identification of multiple cyclin subunits of human P-TEFb.
RL Genes Dev. 12:755-762 (1998).
RN [3]; RE0013617.
RX PUBMED: 10066804.
RA Ping Y. H., Rana T. M.
RT Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes.
RL J. Biol. Chem. 274:7399-7404 (1999).
RN [4]; RE0048096.
RX PUBMED: 15107825.
RA Cabart P., Chew H. K., Murphy S.
RT BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.
RL Oncogene 23:5316-5329 (2004).
RN [5]; RE0055178.
RX PUBMED: 18362169.
RA Nowak D. E., Tian B., Jamaluddin M., Boldogh I., Vergara L. A., Choudhary S., Brasier A. R.
RT RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes.
RL Mol. Cell. Biol. 28:3623-3638 (2008).
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