AC T02727
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ID T02727
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DT 27.05.1999 (created); vma.
DT 28.01.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA cyclinT1
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SY CCNT; CCNT1; cyclin T1; CYCT1; HIVE1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005879 CCNT1; HGNC: CCNT1.
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SF can interact simultaneously with Tat and CDK9 on TAR RNA in vitro [4];
SF the cyclin domain is necessary and sufficient to interact with Tat and promote cooperative binding to TAR RNA in vitro, as well as mediate Tat transactivation in vivo [4];
SF the interaction with Tat requires zinc as well as essential cysteine residues in both proteins (e.g. C261 in human cyclinT1, compare murine cyclinT1 T02732) [4];
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CP ubiquitous (heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas) [1].
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FF human cyclinT1 (but not mouse cyclinT1 or human cyclins T2a or T2b) could support interaction between Tat and TAR in vitro and could rescue Tat activity in nonpermissive rodent cells [2] [3] [4];
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IN T05109 53BP1; human, Homo sapiens.
IN T00140 c-Myc-isoform1; human, Homo sapiens.
IN T02725 cdk9; human, Homo sapiens.
IN T08956 TAFII250; human, Homo sapiens.
IN T00792 tat; HIV-1, human immunodeficiency virus type 1.
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DR TRANSPATH: MO000026703.
DR UniProtKB: O60563;
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RN [1]; RE0013612.
RX PUBMED: 9499409.
RA Peng J., Zhu Y., Milton J. T., Price D. H.
RT Identification of multiple cyclin subunits of human P-TEFb.
RL Genes Dev. 12:755-762 (1998).
RN [2]; RE0013613.
RX PUBMED: 9491887.
RA Wei P., Garber M. E., Fang S.-M., Fischer W. H., Jones K. A.
RT A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.
RL Cell 92:451-462 (1998).
RN [3]; RE0013614.
RX PUBMED: 10049833.
RA Wimmer J., Fujinaga K., Taube R., Cujec T. P., Zhu Y., Peng J., Price D. H., Peterlin B. M.
RT Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b.
RL Virology 255:182-189 (1999).
RN [4]; RE0013615.
RX PUBMED: 9832504.
RA Garber M. E., Wei P., KewalRamani V. N., Mayall T. P., Herrmann C. H., Rice A. P., Littman D. R., Jones K. A.
RT The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.
RL Genes Dev. 12:3512-3527 (1998).
RN [5]; RE0048096.
RX PUBMED: 15107825.
RA Cabart P., Chew H. K., Murphy S.
RT BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.
RL Oncogene 23:5316-5329 (2004).
RN [6]; RE0048248.
RX PUBMED: 12177005.
RA Eberhardy S. R., Farnham P. J.
RT Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter.
RL J. Biol. Chem. 277:40156-40162 (2002).
RN [7]; RE0055178.
RX PUBMED: 18362169.
RA Nowak D. E., Tian B., Jamaluddin M., Boldogh I., Vergara L. A., Choudhary S., Brasier A. R.
RT RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes.
RL Mol. Cell. Biol. 28:3623-3638 (2008).
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