AC T02731
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ID T02731
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DT 28.05.1999 (created); vma.
DT 11.02.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA P-TEFb
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SY positive transcription elongation factor b; TAK (tat-associated kinase).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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SF a heterodimer of cdk9 T02725 and either cyclin T1 T02727, T2a T02728 or T2b T02729 [1];
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FF stimulation of transcriptional elongation in vitro through phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II [1];
FF phosphorylation of the C-terminal domain of RNA pol II by P-TEFb makes it resistant to repression by DSIF T02733 and NELF T02737 [2];
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DR TRANSPATH: MO000026707.
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RN [1]; RE0013612.
RX PUBMED: 9499409.
RA Peng J., Zhu Y., Milton J. T., Price D. H.
RT Identification of multiple cyclin subunits of human P-TEFb.
RL Genes Dev. 12:755-762 (1998).
RN [2]; RE0013620.
RX PUBMED: 10199401.
RA Yamaguchi Y., Takagi T., Wada T., Yano K., Furuya A., Sugimoto S., Hasegawa J., Handa H.
RT NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.
RL Cell 97:41-51 (1999).
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