AC T01494
XX
ID T01494
XX
DT 09.05.1995 (created); ewi.
DT 01.06.2016 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA STAT2
XX
SY (P113); ISGF3alpha p113; signal transducer and activator of transcription 2; STAT113.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004609 STAT2; HGNC: STAT2.
XX
CL C0039; STAT; 6.2.1.0.2.
XX
SF tyrosine-phosphorylation;
SF subunit of ISGF-3alpha;
SF the STAT2 gene comprises 24 exons [3];
XX
FF tyrosine phosphorylation by a cytoplasmic protein kinase which responds to IFN-alpha [1] [2] [5];
FF no phosphorylation in response to IFN-gamma [6];
FF enhances formation of ISGF3 complex [1] [2] [5];
XX
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T01456 IRF-9; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T04759 STAT1; human, Homo sapiens.
IN T01492 STAT1alpha; human, Homo sapiens.
IN T01575 STAT1alpha; mouse, Mus musculus.
IN T01573 STAT1beta; human, Homo sapiens.
XX
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
XX
BS R73496.
BS R25555.
BS R66524.
BS R71171.
BS R71172.
BS R71175.
BS R35057.
BS R25909.
BS R71177.
BS R71178.
BS R71174.
BS R35589.
BS R04650.
XX
DR TRANSPATH: MO000013121.
DR UniProtKB: P52630;
XX
RN [1]; RE0002946.
RX PUBMED: 1280824.
RA Gutch M. J., Daly C., Reich N. C.
RT Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor
RL Proc. Natl. Acad. Sci. USA 89:11411-11415 (1992).
RN [2]; RE0003478.
RX PUBMED: 1638633.
RA Fu X.-Y.
RT A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s)
RL Cell 70:323-335 (1992).
RN [3]; RE0003482.
RX PUBMED: 7885841.
RA Yan R., Qureshi S., Zhong Z., Wen Z., Darnell jr J. E.
RT The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2
RL Nucleic Acids Res. 23:459-463 (1995).
RN [4]; RE0003489.
RX PUBMED: 1502203.
RA Schindler C., Fu X.-Y., Improta T., Aebersold R., Darnell J. E.
RT Protein of ISGF3: One gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha
RL Proc. Natl. Acad. Sci. USA 89:7836-7839 (1992).
RN [5]; RE0003490.
RX PUBMED: 1496401.
RA Schindler C., Shuai K., Prezioso V. R., Darnell J. E.
RT Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
RL Science 257:809-813 (1992).
RN [6]; RE0003491.
RX PUBMED: 1281555.
RA Shuai K., Schindler C., Prezioso V. R., Darnell J. E.
RT Activation of transcription by IFN-gamma tyrosine phosphorylation of a 91-kDa DNA binding protein
RL Science 258:1808-1812 (1992).
RN [7]; RE0003508.
RX PUBMED: 1502204.
RA Fu X.-Y., Schindler C., Improta T., Aebersold R., Darnell J. E.
RT The proteins of ISGF3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction
RL Proc. Natl. Acad. Sci. USA 89:7840-7843 (1992).
RN [8]; RE0003510.
RX PUBMED: 8197134.
RA Improta T., Schindler C., Horvath C. M., Kerr I. M., Stark G. R., Darnell J. E.
RT Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein
RL Proc. Natl. Acad. Sci. USA 91:4776-4780 (1994).
RN [9]; RE0003816.
RX PUBMED: 8524306.
RA Qureshi S. A., Leung S., Kerr I. M., Stark G. R., Darnell jr J. E.
RT Function of Stat2 protein in transcriptional activation by alpha interferon
RL Mol. Cell. Biol. 16:288-293 (1996).
RN [10]; RE0012679.
RX PUBMED: 8605876.
RA Yan H., Krishnan K., Greenlund A. C., Gupta S., Lim J. T. E., Schreiber R. D., Schindler C. W., Krolewski J. J.
RT Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein
RL EMBO J. 15:1064-1074 (1996).
RN [11]; RE0019119.
RX PUBMED: 9020188.
RA BLUYSSEN H.A., LEVY D.E.
RT Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.
RL J. Biol. Chem. 272:4600-4605 (1997).
RN [12]; RE0032828.
RX PUBMED: 11801527.
RA Miscia S., Marchisio M., Grilli A., Di Valerio V., Centurione L., Sabatino G., Garaci F., Zauli G., Bonvini E., Di Baldassarre A.
RT Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells.
RL Cell Growth Differ. 13:13-8 (2002).
RN [13]; RE0033178.
RX PUBMED: 14645718.
RA Nusinzon I., Horvath C. M.
RT Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1.
RL Proc. Natl. Acad. Sci. USA 100:14742-7 (2003).
RN [14]; RE0044212.
RX PUBMED: 7813427.
RA Abramovich C., Shulman L. M., Ratovitski E., Harroch S., Tovey M., Eid P., Revel M.
RT Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta
RL EMBO J. 13:5871-7 (1994).
RN [15]; RE0044213.
RX PUBMED: 8119902.
RA Colamonici O. R., Domanski P., Krolewski J. J., Fu X. Y., Reich N. C., Pfeffer L. M., Sweet M. E., Platanias L. C.
RT Interferon alpha (IFN alpha) signaling in cells expressing the variant form of the type I IFN receptor
RL J. Biol. Chem. 269:5660-5 (1994).
RN [16]; RE0049465.
RX PUBMED: 16273093.
RA Jones R. B., Gordus A., Krall J. A., MacBeath G.
RT A quantitative protein interaction network for the ErbB receptors using protein microarrays.
RL Nature 439:168-174 (2006).
RN [17]; RE0053870.
RX PUBMED: 17923090.
RA Tang X., Gao J. S., Guan Y. J., McLane K. E., Yuan Z. L., Ramratnam B., Chin Y. E.
RT Acetylation-dependent signal transduction for type I interferon receptor.
RL Cell 131:93-105 (2007).
RN [18]; RE0055106.
RX PUBMED: 18635538.
RA Kubota T., Matsuoka M., Chang T. H., Tailor P., Sasaki T., Tashiro M., Kato A., Ozato K.
RT Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression.
RL J. Biol. Chem. 283:25660-25670 (2008).
RN [19]; RE0065057.
RX PUBMED: 16280321.
RA Shang L., Tomasi T. B.
RT The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons.
RL J. Biol. Chem. 281:1876-1884 (2006).
RN [20]; RE0065662.
RX PUBMED: 16000408.
RA Du Z., Shen Y., Yang W., Mecklenbrauker I., Neel B. G., Ivashkiv L. B.
RT Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway.
RL Proc. Natl. Acad. Sci. USA 102:10267-10272 (2005).
RN [21]; RE0065735.
RX PUBMED: 15883164.
RA Yang C. H., Murti A., Valentine W. J., Du Z., Pfeffer L. M.
RT Interferon alpha activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway.
RL J. Biol. Chem. 280:25849-25853 (2005).
RN [22]; RE0065916.
RX PUBMED: 17942603.
RA Panaretakis T., Hjortsberg L., Tamm K. P., Bjorklund A. C., Joseph B., Grander D.
RT Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin.
RL Mol. Biol. Cell 19:41-50 (2008).
RN [23]; RE0065978.
RX PUBMED: 19457860.
RA Gad H. H., Dellgren C., Hamming O. J., Vends S., Paludan S. R., Hartmann R.
RT Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family.
RL J. Biol. Chem. 284:20869-20875 (2009).
RN [24]; RE0066013.
RX PUBMED: 18698163.
RA Maher S. G., Sheikh F., Scarzello A. J., Romero-Weaver A. L., Baker D. P., Donnelly R. P., Gamero A. M.
RT IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity.
RL Cancer Biol. Ther. 7:1109-1115 (2008).
RN [25]; RE0066165.
RX PUBMED: 17627610.
RA Marijanovic Z., Ragimbeau J., Van der Heyden J., Uze G., Pellegrini S.
RT Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2.
RL Biochem. J. 407:141-151 (2007).
RN [26]; RE0066190.
RX PUBMED: 20048147.
RA Wang N., Dong Q., Li J., Jangra R. K., Fan M., Brasier A. R., Lemon S. M., Pfeffer L. M., Li K.
RT Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent.
RL J. Biol. Chem. 285:6080-6090 (2010).
RN [27]; RE0066251.
RX PUBMED: 11786546.
RA Nguyen V. P., Saleh A. Z., Arch A. E., Yan H., Piazza F., Kim J., Krolewski J. J.
RT Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling.
RL J. Biol. Chem. 277:9713-9721 (2002).
RN [28]; RE0066328.
RX PUBMED: 17167270.
RA Buttmann M., Berberich-Siebelt F., Serfling E., Rieckmann P.
RT Interferon-beta is a potent inducer of interferon regulatory factor-1/2-dependent IP-10/CXCL10 expression in primary human endothelial cells.
RL J. Vasc. Res. 44:51-60 (2007).
RN [29]; RE0066398.
RX PUBMED: 7531704.
RA Velazquez L., Mogensen K. E., Barbieri G., Fellous M., Uze G., Pellegrini S.
RT Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.
RL J. Biol. Chem. 270:3327-3334 (1995).
RN [30]; RE0066436.
RX PUBMED: 8617715.
RA David M., Petricoin E 3. r. d., Larner A. C.
RT Activation of protein kinase A inhibits interferon induction of the Jak/Stat pathway in U266 cells.
RL J. Biol. Chem. 271:4585-4588 (1996).
RN [31]; RE0066578.
RX PUBMED: 12105218.
RA Velichko S., Wagner T. C., Turkson J., Jove R., Croze E.
RT STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.
RL J. Biol. Chem. 277:35635-35641 (2002).
RN [32]; RE0066599.
RX PUBMED: 15970687.
RA Lei H., Furlong P. J., Ra J. H., Mullins D., Cantor R., Fraker D. L., Spitz F. R.
RT AKT activation and response to interferon-beta in human cancer cells.
RL Cancer Biol. Ther. 4:709-715 (2005).
RN [33]; RE0066623.
RX PUBMED: 18456658.
RA Gakovic M., Ragimbeau J., Francois V., Constantinescu S. N., Pellegrini S.
RT The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor.
RL J. Biol. Chem. 283:18522-18529 (2008).
RN [34]; RE0066658.
RX PUBMED: 15210966.
RA Chang H. M., Paulson M., Holko M., Rice C. M., Williams B. R., Marie I., Levy D. E.
RT Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 101:9578-9583 (2004).
RN [35]; RE0068867.
RX PUBMED: 17507495.
RA Zhou Z., Hamming O. J., Ank N., Paludan S. R., Nielsen A. L., Hartmann R.
RT Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases.
RL J. Virol. 81:7749-7758 (2007).
RN [36]; RE0070000.
RX PUBMED: 12517937.
RA Dondi E., Rogge L., Lutfalla G., Uze G., Pellegrini S.
RT Down-modulation of responses to type I IFN upon T cell activation.
RL J. Immunol. 170:749-756 (2003).
XX
//