TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01456 XX ID T01456 XX DT 24.04.1995 (created); ewi. DT 28.06.2013 (updated); yre. CO Copyright (C), QIAGEN. XX FA IRF-9 XX SY IRF-9; IRTF; ISGF-3gamma; p48. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G005497 IRF9; HGNC: IRF9. XX CL C0022; trp; XX SF major DNA-binding subunit of ISGF-3 [1]; SF DNA-binding domain within the N-terminal part [4]; SF DNA-binding 25-fold enhanced by association with ISGF-3alpha [1]; SF IAD domain, conserved within IRF family, is responsible for protein-protein interactions [5]; XX FF induction by IFN-gamma; FF phosphorylation and association with ISGF-3alpha prior to nuclear translocation and binding to DNA [4] [1]; FF inhibited by E1A; XX IN T01455 ISGF-3alpha; human, Homo sapiens. IN T10338 STAT2-isoform1; human, Homo sapiens. IN T01494 STAT2; human, Homo sapiens. XX MX M04021 V$IRF9_01. MX M08887 V$IRF_Q4. MX M00972 V$IRF_Q6_01. XX BS R25556. BS R25968. BS R34351. XX DR TRANSPATH: MO000007759. DR UniProtKB: Q00978; XX RN [1]; RE0000680. RX PUBMED: 2249773. RA Kessler D. S., Veals S. A., Fu X.-X., Levy D. E. RT Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator RL Genes Dev. 4:1753-1765 (1990). RN [2]; RE0002946. RX PUBMED: 1280824. RA Gutch M. J., Daly C., Reich N. C. RT Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor RL Proc. Natl. Acad. Sci. USA 89:11411-11415 (1992). RN [3]; RE0003206. RX PUBMED: 1630447. RA Veals S. A., Schindler C., Leonhard D., Fu X.-Y., Aebersold R., Darnell jr J. E., Levy D. E. RT Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins RL Mol. Cell. Biol. 12:3315-3324 (1992). RN [4]; RE0003476. RX PUBMED: 8417326. RA Veals S. A., Santa Maria T., Levy D. E. RT Two domains of ISGF3gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity RL Mol. Cell. Biol. 13:196-206 (1993). RN [5]; RE0017830. RX PUBMED: 10586038. RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z. RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors. RL J. Immunol. 163:6468-6478 (1999). RN [6]; RE0053870. RX PUBMED: 17923090. RA Tang X., Gao J. S., Guan Y. J., McLane K. E., Yuan Z. L., Ramratnam B., Chin Y. E. RT Acetylation-dependent signal transduction for type I interferon receptor. RL Cell 131:93-105 (2007). RN [7]; RE0066599. RX PUBMED: 15970687. RA Lei H., Furlong P. J., Ra J. H., Mullins D., Cantor R., Fraker D. L., Spitz F. R. RT AKT activation and response to interferon-beta in human cancer cells. RL Cancer Biol. Ther. 4:709-715 (2005). RN [8]; RE0066658. RX PUBMED: 15210966. RA Chang H. M., Paulson M., Holko M., Rice C. M., Williams B. R., Marie I., Levy D. E. RT Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. RL Proc. Natl. Acad. Sci. USA 101:9578-9583 (2004). XX //