AC T10338
XX
ID T10338
XX
DT 22.03.2007 (created); jag.
DT 28.06.2013 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA STAT2-isoform1
XX
SY (P113); ISGF3alpha p113; Long; signal transducer and activator of transcription 2; STAT113.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004609 STAT2; HGNC: STAT2.
XX
CL C0039; STAT; 6.2.1.0.2.1.
XX
SZ 851 AA; 97.9 kDa (cDNA) (calc.), 113 kDa (SDS)
XX
SQ MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLF
SQ FHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQPFSQDPTQLAEMIFNLLLEEKRILI
SQ QAQRAQLEQGEPVLETPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRYKIQ
SQ AKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIELLLPKLEEWKA
SQ QQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLTKGVDLR
SQ NAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTVE
SQ VSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKGSNKG
SQ PLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLSPNLQ
SQ NQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLLSWAD
SQ FTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTMSGTFLL
SQ RFSESSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENP
SQ LRFLYPRIPRDEAFGCYYQEKVNLQERRKYLKHRLIVVSNRQVDELQQPLELKPEPELES
SQ LELELGLVPEPELSLDLEPLLKAGLDLGPELESVLESTLEPVIEPTLCMVSQTVPEPDQG
SQ PVSQPVPEPDLPCDLRHLNTEPMEIFRNCVKIEEIMPNGDPLLAGQNTVDEVYVSRPSHF
SQ YTDGPLMPSDF
XX
SC translated from EMBL #M97934
XX
FT 2 125 
PF02865; STAT protein, protein interaction domain.
FT 139 314 
PF01017; STAT protein, all-alpha domain.
FT 316 566 
PF02864; STAT protein, DNA binding domain.
FT 422 709 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 570 654 
SM00252; SH2_5.
FT 572 648 
PF00017; SH2 domain.
FT 572 667 
PS50001; SH2.
FT 690 690 
phosphorylated tyrosine residue [8].
FT 801 851 
required for trans-activation [9].
XX
IN T01456 IRF-9; human, Homo sapiens.
XX
DR TRANSPATH: MO000103167.
DR EMBL: M97934;
DR EMBL: U18671;
DR UniProtKB: P52630-1;
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RN [1]; RE0002946.
RX PUBMED: 1280824.
RA Gutch M. J., Daly C., Reich N. C.
RT Tyrosine phosphorylation is required for activation of an alpha interferon-stimulated transcription factor
RL Proc. Natl. Acad. Sci. USA 89:11411-11415 (1992).
RN [2]; RE0003478.
RX PUBMED: 1638633.
RA Fu X.-Y.
RT A transcription factor with SH2 and SH3 domains is directly activated by an interferon alpha-induced cytoplasmic protein tyrosine kinase(s)
RL Cell 70:323-335 (1992).
RN [3]; RE0003482.
RX PUBMED: 7885841.
RA Yan R., Qureshi S., Zhong Z., Wen Z., Darnell jr J. E.
RT The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2
RL Nucleic Acids Res. 23:459-463 (1995).
RN [4]; RE0003489.
RX PUBMED: 1502203.
RA Schindler C., Fu X.-Y., Improta T., Aebersold R., Darnell J. E.
RT Protein of ISGF3: One gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha
RL Proc. Natl. Acad. Sci. USA 89:7836-7839 (1992).
RN [5]; RE0003490.
RX PUBMED: 1496401.
RA Schindler C., Shuai K., Prezioso V. R., Darnell J. E.
RT Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
RL Science 257:809-813 (1992).
RN [6]; RE0003491.
RX PUBMED: 1281555.
RA Shuai K., Schindler C., Prezioso V. R., Darnell J. E.
RT Activation of transcription by IFN-gamma tyrosine phosphorylation of a 91-kDa DNA binding protein
RL Science 258:1808-1812 (1992).
RN [7]; RE0003508.
RX PUBMED: 1502204.
RA Fu X.-Y., Schindler C., Improta T., Aebersold R., Darnell J. E.
RT The proteins of ISGF3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction
RL Proc. Natl. Acad. Sci. USA 89:7840-7843 (1992).
RN [8]; RE0003510.
RX PUBMED: 8197134.
RA Improta T., Schindler C., Horvath C. M., Kerr I. M., Stark G. R., Darnell J. E.
RT Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein
RL Proc. Natl. Acad. Sci. USA 91:4776-4780 (1994).
RN [9]; RE0003816.
RX PUBMED: 8524306.
RA Qureshi S. A., Leung S., Kerr I. M., Stark G. R., Darnell jr J. E.
RT Function of Stat2 protein in transcriptional activation by alpha interferon
RL Mol. Cell. Biol. 16:288-293 (1996).
RN [10]; RE0019119.
RX PUBMED: 9020188.
RA BLUYSSEN H.A., LEVY D.E.
RT Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.
RL J. Biol. Chem. 272:4600-4605 (1997).
RN [11]; RE0066195.
RX PUBMED: 18456457.
RA El Fiky A., Pioli P., Azam A., Yoo K., Nastiuk K. L., Krolewski J. J.
RT Nuclear transit of the intracellular domain of the interferon receptor subunit IFNaR2 requires Stat2 and Irf9.
RL Cell. Signal. 20:1400-1408 (2008).
RN [12]; RE0066676.
RX PUBMED: 15194680.
RA Sakamoto S., Potla R., Larner A. C.
RT Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes.
RL J. Biol. Chem. 279:40362-40367 (2004).
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