AC T02483
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ID T02483
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DT 15.06.1998 (created); ewi.
DT 03.01.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA TIF2
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SY glucocorticoid receptor interacting protein 1; GR interacting protein 1; GRIP1; transcriptional intermediary factor 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004703 NCOA2; HGNC: NCOA2.
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CL C0010; bHLH; 1.2.5.3.2.
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SF contains several NR box motifs within nuclear receptor interacting domain that are important for interaction with cognate nuclear receptors in ligand-bound status (via AF-2 domain) [4] [3];
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FF coactivator specifically of nuclear receptor AF-2 function [2];
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IN T08487 AR-isoform1; human, Homo sapiens.
IN T00040 AR; human, Homo sapiens.
IN T27166 BAF57; mouse, Mus musculus.
IN T02872 beta-catenin; human, Homo sapiens.
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T09602 ER; Mammalia.
IN T05070 GMEB-1; mouse, Mus musculus.
IN T08525 LRH1-isoform1; human, Homo sapiens.
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DR TRANSPATH: MO000026464.
DR UniProtKB: Q15596;
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RN [1]; RE0006133.
RX PUBMED: 9192892.
RA Torchia J., Rose D. W., Inostroza J., Westin S., Glass C. K., Rosenfeld M. G.
RT The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
RL Nature 387:677-684 (1997).
RN [2]; RE0006907.
RX PUBMED: 8670870.
RA Voegel J. J., Heine M. J. S., Zechel C., Chambon P., Gronemeyer H.
RT TIF2, a160kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors
RL EMBO J. 15:3667-3675 (1996).
RN [3]; RE0006908.
RX PUBMED: 9430642.
RA Voegel J. J., Heine M. J., Tini M., Vivat V., Chambon P., Gronemeyer H.
RT The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
RL EMBO J. 17:507-519 (1998).
RN [4]; RE0016476.
RX PUBMED: 10713439.
RA Leo C., Chen J. D.
RT The SRC family of nuclear receptor coactivators
RL Gene 245:1-11 (2000).
RN [5]; RE0017628.
RX PUBMED: 10692587.
RA Jimenez-Lara A. M., Heine M. J., Gronemeyer H.
RT Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family
RL FEBS Lett. 468:203-210 (2000).
RN [6]; RE0031565.
RX PUBMED: 14638683.
RA Li H., Kim J. H., Koh S. S., Stallcup M. R.
RT Synergistic effects of coactivators GRIP1 and beta-catenin on gene activation: cross-talk between androgen receptor and Wnt signaling pathways.
RL J. Biol. Chem. 279:4212-20 (2004).
RN [7]; RE0048217.
RX PUBMED: 11971985.
RA Wu R. C., Qin J., Hashimoto Y., Wong J., Xu J., Tsai S. Y., Tsai M. J., O'Malley B. W.
RT Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.
RL Mol. Cell. Biol. 22:3549-3561 (2002).
RN [8]; RE0053397.
RX PUBMED: 14662770.
RA Gregory C. W., Fei X., Ponguta L. A., He B., Bill H. M., French F. S., Wilson E. M.
RT Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer.
RL J. Biol. Chem. 279:7119-7130 (2004).
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