AC T02758
AS T00012.
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ID T02758
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DT 07.06.1999 (created); mpr.
DT 08.03.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA HNF-4
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SY AF-1; hepatocyte nuclear factor 4; HNF4; NR2A1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001926 HNF4A; HGNC: HNF4A.
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CL C0002; CC (rec).
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SZ 465 AA; 51.8 kDa (cDNA) (calc.).
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SQ MDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATG
SQ KHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEA
SQ VQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCE
SQ SMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDY
SQ IVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIK
SQ RLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL
SQ LQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAAT
SQ PETPQPSPPGASGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
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SC Swiss-Prot#P41235
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FT 2 379 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 48 119 
SM00399; c4gold.
FT 48 123 
PS51030; NUCLEAR_REC_DBD_2.
FT 49 124 
PF00105; Zinc finger, C4 type (two domains).
FT 180 339 
SM00430; holi.
FT 183 364 
PF00104; Ligand-binding domain of nuclear hormon.
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SF nuclear activity, may be composed of HNF-4alpha, HNF-4gamma;
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FF activates several intestine-specific promoters [5] [7];
FF activates liver-specific promoters [8] [4];
FF previously known as AF-1 binding to apolipoprotein promoters [4];
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IN T02214 CBP-isoform1; human, Homo sapiens.
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MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M02220 V$HNF4A_03.
MX M07321 V$HNF4A_Q3.
MX M00764 V$HNF4DR1_Q3.
MX M00134 V$HNF4_01.
MX M00411 V$HNF4_01_B.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
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BS R01612.
BS R16068.
BS R20717.
BS R08883.
BS R19213.
BS R15905.
BS R15898.
BS R13209.
BS R15918.
BS R15920.
BS R16051.
BS R15925.
BS R15927.
BS R15939.
BS R15891.
BS R16048.
BS R15940.
BS R15941.
BS R13070.
BS R12987.
BS R03881.
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DR TRANSPATH: MO000026732.
DR EMBL: X76930;
DR UniProtKB: P41235;
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RN [1]; RE0000898.
RX PUBMED: 2777781.
RA Leff T., Reue K., Melian A., Culver H., Breslow J. L.
RT A Regulatory Element in the ApoCIII Promoter That Directs Hepatic Specific Transcription Binds to Proteins in Expressing and Nonexpressing Cell Types
RL J. Biol. Chem. 264:16132-16137 (1989).
RN [2]; RE0002747.
RX PUBMED: 2161847.
RA Metzger S., Leff T., Breslow J. L.
RT Nuclear factors AF-1 and C/EBP bind to the human ApoB gene promoter and modulate its transcriptional activity in hepatic cells
RL J. Biol. Chem. 265:9978-9983 (1990).
RN [3]; RE0006828.
RX PUBMED: 7926813.
RA Chartier F. L., Bossu J.-P., Laudet V., Fruchart J.-C., Laine B.
RT Full sequence of the human HNF4 cDNA
RL Gene 147:269-272 (1994).
RN [4]; RE0007472.
RX PUBMED: 8344962.
RA Metzger S., Halaas J. L., Breslow J. L., Sladek F. M.
RT Orphan Receptor HNF-4 and bZip protein C/EBPalpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription
RL J. Biol. Chem. 268:16831- 16838 (1993).
RN [5]; RE0011477.
RX PUBMED: 7650015.
RA Bisaha J. G., Simon T. C., Gordon J. I., Breslow J. L.
RT Characterization of an enhancer element in the human apolipoprotein C-III gene that regulates human apolipoprotein A-I gene expression in the intestinal epithelium
RL J. Biol. Chem. 270:19979-19988 (1995).
RN [6]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [7]; RE0014425.
RX PUBMED: 10070050.
RA Swenson E. S., Mann E. A., Jump M. L., Giannella R. A.
RT Hepatocyte nuclear factor-4 regulates intestinal expression of the guanylin/heat-stable toxin receptor
RL Am. J. Physiol. 276:G728-G736 (1999).
RN [8]; RE0018060.
RX PUBMED: 11574686.
RA del Castillo-Olivares A., Gil G.
RT Suppression of sterol 12alpha-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism.
RL Nucleic Acids Res. 29:4035-4042 (2001).
RN [9]; RE0016571.
RX PUBMED: 8455618.
RA Jackson D. A., Rowader K. E., Stevens K., Jiang C., Milos P., Zaret K. S.
RT Modulation of liver-specific transcription by interaction between Hepatocyte Nuclear Factor 3 and Nuclear Factor 1 binding DNA in close apposition.
RL Mol. Cell. Biol. 13:2401-2410 (1993).
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