AC T00900
XX
ID T00900
XX
DT 10.11.1992 (created); ewi.
DT 18.04.2007 (updated); sra.
CO Copyright (C), QIAGEN.
XX
FA WT1 I -KTS
XX
SY Swiss-Prot isoform-2; Wilms tumor zinc finger protein; WT-ZFP; WT1(-/-); WT33.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004120 WT1; HGNC: WT1.
XX
CL C0001; CH; 2.3.3.0.21.2.
XX
SZ 429 AA; 47.2 kDa (cDNA) (calc.).
XX
SQ MGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAP
SQ PPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQA
SQ SSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHED
SQ PMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQ
SQ MNLGATLKGHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASET
SQ SEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRH
SQ TGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQR
SQ NMTKLQLAL
XX
SC edited from Swiss-Prot #P19544
XX
FT 1 304 
PF02165; Wilm's tumour protein.
FT 306 330 
PF00096; zf-C2H2.
FT 306 330 
SM00355; c2h2final6.
FT 306 335 
PS50157; ZINC_FINGER_C2H2_2.
FT 336 360 
PF00096; zf-C2H2.
FT 336 360 
SM00355; c2h2final6.
FT 336 365 
PS50157; ZINC_FINGER_C2H2_2.
FT 366 388 
PF00096; zf-C2H2.
FT 366 388 
SM00355; c2h2final6.
FT 366 393 
PS50157; ZINC_FINGER_C2H2_2.
FT 394 418 PF00096; zf-C2H2.
FT 394 418 SM00355; c2h2final6.
FT 394 423 PS50157; ZINC_FINGER_C2H2_2.
XX
SF 4 zinc finger motifs;
SF alternative splice variant lacking 17 AA (250-266 of WT1) and 408-410 (K-T-S);
XX
FF binding to RNA via zinc finger [2];
XX
IN T09637 ER-alpha; Mammalia.
IN T00671 p53; human, Homo sapiens.
IN T06016 p63; rat, Rattus norvegicus.
IN T06006 p73alpha; monkey, Cercopithecus aethiops.
IN T06014 p73beta; monkey, Cercopithecus aethiops.
IN T23097 Slim-3; Mammalia.
XX
MX M07436 V$WT1_Q4.
MX M01118 V$WT1_Q6.
MX M02036 V$WT1_Q6_01.
MX M03893 V$WT1_Q6_02.
XX
BS R04924.
BS R02307.
BS R02308.
BS R02309.
BS R02310.
BS R02311.
BS R02312.
BS R15141.
BS R04858.
BS R04859.
BS R04860.
BS R04861.
BS R04862.
BS R04863.
BS R04864.
BS R04865.
BS R04866.
BS R04867.
BS R04868.
BS R21055.
BS R04925.
BS R02262.
XX
DR TRANSPATH: MO000025253.
DR UniProtKB: P19544-2;
XX
RN [1]; RE0002675.
RX PUBMED: 1321494.
RA Bickmore W. A., Oghene K., Little M. H., Seawright A., van Heyningen V., Hastie N. D.
RT Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript
RL Science 257:235-237 (1992).
RN [2]; RE0006498.
RX PUBMED: 7736591.
RA Larsson S. H., Charlieu J.-P., Miyagawa K., Engelkamp D., Rassoulzadegan M., Ross A., Cuzin F., van Heyningen V., Hastie N. D.
RT Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing
RL Cell 81:391-401 (1995).
RN [3]; RE0049501.
RX PUBMED: 16087727.
RA Reizner N., Maor S., Sarfstein R., Abramovitch S., Welshons W. V., Curran E. M., Lee A. V., Werner H.
RT The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cells.
RL J. Mol. Endocrinol. 35:135-144 (2005).
RN [4]; RE0049561.
RX PUBMED: 12151099.
RA Du X., Hublitz P., Gunther T., Wilhelm D., Englert C., Schule R.
RT The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation.
RL Biochim. Biophys. Acta 1577:93-101 (2002).
XX
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