AC T04222
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ID T04222
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DT 23.01.2001 (created); dkl.
DT 15.05.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA Smad5
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SY Smad-5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002365 SMAD5; HGNC: SMAD5.
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CL C0041; SMAD; 7.1.1.1.4.
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SF NLS (Nuclear Localization Signal) determines the ligand-induced nuclear translocation [3];
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CP human CD3+ cells, Histopaque-1077-separated peripheral blood granulocytes, skin fibroblasts, Histopaque-1077-separated mononuclear and polymorphonuclear bone marrow cells and human erythroleukemia cell line K562 cell line HL60 [2].
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IN T34370 RN3; human, Homo sapiens.
IN T22876 YAP; human, Homo sapiens.
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MX M03846 V$SMAD5_Q5.
MX M08829 V$SMAD5_Q5_01.
MX M08897 V$SMAD_Q4.
MX M00974 V$SMAD_Q6_01.
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BS R70852.
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DR TRANSPATH: MO000020635.
DR UniProtKB: Q99717; Q99717.
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RN [1]; RE0006139.
RX PUBMED: 9214508.
RA Shi Y., Hata A., Lo R. S., Massague J., Pavletich N. P.
RT A strucural basis for mutational inactivation of the tumour suppressor Smad4
RL Nature 388:87-93 (1997).
RN [2]; RE0015612.
RX PUBMED: 9264367.
RA Zavadil J., Brezinova J., Svoboda P., Zemanova Z., Michalova K.
RT Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost and not mutated in the retained allele in human leukemia cell line HL60
RL Leukemia 11:1187-1192 (1997).
RN [3]; RE0016203.
RX PUBMED: 10884415.
RA Xiao Z., Liu X., Henis Y. I., Lodish H. F.
RT A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation.
RL Proc. Natl. Acad. Sci. USA 97:7853-7858 (2000).
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