AC T04234
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ID T04234
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DT 25.01.2001 (created); dkl.
DT 26.12.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA Smad7
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SY Smad-7.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002309 Smad7.
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CL C0041; SMAD; 7.1.1.3.2.
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SF Smad7B is described in EMBL #MMSMAD7B with one AA shorter in sequence (425 AA);
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CP (adult): brain, heart, kidney, spleen, thymus, liver [2].
EX brain,,,adult; detectable; Northern blot; RNA (undefined); [1].
EX heart,,,adult; detectable; Northern blot; RNA (undefined); [1].
EX kidney (right and left),,,adult; detectable; Northern blot; RNA (undefined); [1].
EX liver,,,adult; detectable; Northern blot; RNA (undefined); [1].
EX lung,,,adult; detectable; Northern blot; RNA (undefined); [1].
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FF in xenopus development embryos fail to form head or tail without Smad7 [1];
FF Smad7 inhibits BMP2-induced phosphorylation of Smad1 and Smad5;
FF BMP2 and Smad7 enhance cell cycle arrest in the G1-phase [3];
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IN T22876 YAP; human, Homo sapiens.
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MX M00974 V$SMAD_Q6_01.
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DR TRANSPATH: MO000020318.
DR UniProtKB: O35253; O35253.
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RN [1]; RE0006197.
RX PUBMED: 9335507.
RA Nakao A., Afrakhte M., Moren A., Nakayama T., Christian J. L., Heuchel R., Itoh S., Kawabata M., Heldin N. E., Heldin C. H., ten Dijke P.
RT Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
RL Nature 389:631-635 (1997).
RN [2]; RE0015639.
RX PUBMED: 10828018.
RA Kitamura K., Aota S., Sakamoto R., Yoshikawa S., Okazaki K.
RT Smad7 selectively interfere with different pathways of activin signallin and inhibits erythroid leukemia cell differentiation
RL Blood 95:3371-3379 (2000).
RN [3]; RE0020663.
RX PUBMED: 10224135.
RA Ishisaki A., Yamato K., Hashimoto S., Nakao A., Tamaki K., Nonaka K., ten Dijke P., Sugino H., Nishihara T.
RT Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells
RL J. Biol. Chem. 274:13637-13642 (1999).
RN [4]; RE0025738.
RX PUBMED: 12118366.
RA Ferrigno O., Lallemand F., Verrecchia F., L'Hoste S., Camonis J., Atfi A., Mauviel A.
RT Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling.
RL Oncogene 21:4879-84 (2002).
RN [5]; RE0035894.
RX PUBMED: 15496141.
RA Kuratomi G., Komuro A., Goto K., Shinozaki M., Miyazawa K., Miyazono K., Imamura T.
RT NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.
RL Biochem. J. 386:461-470 (2005).
RN [6]; RE0041180.
RX PUBMED: 12815042.
RA Imoto S., Sugiyama K., Muromoto R., Sato N., Yamamoto T., Matsuda T.
RT Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3
RL J. Biol. Chem. 278:34253-8 (2003).
RN [7]; RE0046995.
RX PUBMED: 15221015.
RA Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K., Miyazawa K.
RT Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)
RL Oncogene 23:6914-23 (2004).
RN [8]; RE0060449.
RX PUBMED: 16278212.
RA Dooley S., Said H. M., Gressner A. M., Floege J., En-Nia A., Mertens P. R.
RT Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects.
RL J. Biol. Chem. 281:1784-1795 (2006).
RN [9]; RE0071922.
RX PUBMED: 21931165.
RA Zhao Y., Thornton A. M., Kinney M. C., Ma C. A., Spinner J. J., Fuss I. J., Shevach E. M., Jain A.
RT The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor beta (TGF-beta) signaling and the development of regulatory T cells.
RL J. Biol. Chem. 286:40520-40530 (2011).
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