AC T06168
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ID T06168
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DT 21.09.2004 (created); oke.
DT 06.05.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA p63alpha
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SY p63 TA alpha; TAp63; TAp63alpha; Trp53rp1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009623 Trp63.
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CL C0057; P53; 6.3.1.0.2.1.
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SZ 680 AA; 76.8 kDa (calc.).
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SQ MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWD
SQ FLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSM
SQ DQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
SQ FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEV
SQ VKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFT
SQ TVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR
SQ KQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKES
SQ LELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQ
SQ LINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPP
SQ PPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKG
SQ ILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWND
SQ FNFDMDSRRNKQQRIKEEGE
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SC Swiss-Prot#O88898-1
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FT 152 445 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 163 359 
PF00870; P53 DNA-binding domain.
FT 391 432 
PF07710; P53 tetramerisation motif.
FT 541 607 
PF07647; SAM domain (Sterile alpha motif).
FT 541 607 
SM00454; SAM.
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SF one of the alternative products of the mouse trp63 gene: p63alpha T06168, p63beta T06290, p63gamma T06291, DeltaNp63alpha T06011, DeltaNp63beta T06010, DeltaNp63gamma T06292 [3];
SF transactivation domain (TA) is important for DNA-damage induced apoptosis [2];
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FF is required for DNA-damage induced apoptosis [2];
FF can bind p53 consensus elements [2];
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IN T06168 p63alpha; mouse, Mus musculus.
IN T22876 YAP; human, Homo sapiens.
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MX M00761 V$P53DECAMER_Q2.
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BS R15778.
BS R15779.
BS R15777.
BS R11317.
BS R11318.
BS R11441.
BS R11442.
BS R11437.
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DR TRANSPATH: MO000042314.
DR EMBL: AF075436; AF075436.
DR EMBL: AF075439;
DR EMBL: AF533892; AF533892.
DR UniProtKB: O88898-1;
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RN [1]; RE0024344.
RX PUBMED: 11278685.
RA Strano S., Munarriz E., Rossi M., Castagnoli L., Shaul Y., Sacchi A., Oren M., Sudol M., Cesareni G., Blandino G.
RT Physical interaction with Yes-associated protein enhances p73 transcriptional activity.
RL J. Biol. Chem. 276:15164-15173 (2001).
RN [2]; RE0024849.
RX PUBMED: 11932750.
RA Flores E. R., Tsai K. Y., Crowley D., Sengupta S., Yang A., McKeon F., Jacks T.
RT p63 and p73 are required for p53-dependent apoptosis in response to DNA damage.
RL Nature 416:560-564 (2002).
RN [3]; RE0024981.
RX PUBMED: 10227294.
RA Yang A., Schweitzer R., Sun D., Kaghad M., Walker N., Bronson R. T., Tabin C., Sharpe A., Caput D., Crum C., McKeon F.
RT p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development.
RL Nature 398:714-718 (1999).
RN [4]; RE0050255.
RX PUBMED: 16861923.
RA Rossi M., De Simone M., Pollice A., Santoro R., La Mantia G., Guerrini L., Calabro V.
RT Itch/AIP4 associates with and promotes p63 protein degradation.
RL Cell Cycle 5:1816-1822 (2006).
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