AC T06011
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ID T06011
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DT 09.06.2004 (created); cch.
DT 06.05.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA DeltaNp63alpha
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SY DN p63alpha; Trp53rp1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009623 Trp63.
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CL C0057; P53; 6.3.1.0.2.2.
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SZ 586 AA; 65.8 kDa (calc.).
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SQ MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSS
SQ TFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIK
SQ VMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
SQ YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQV
SQ LGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRR
SQ SPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQ
SQ SQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAG
SQ DMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIY
SQ QIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETR
SQ GERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE
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SC translated from EMBL #AF075439
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FT 58 351 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 69 265 
PF00870; P53 DNA-binding domain.
FT 297 338 
PF07710; P53 tetramerisation motif.
FT 447 513 
PF07647; SAM domain (Sterile alpha motif).
FT 447 513 
SM00454; SAM.
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SF one of the alternative products of the mouse trp63 gene: p63alpha T06168, p63beta T06290, p63gamma T06291, DeltaNp63alpha T06011, DeltaNp63beta T06010, DeltaNp63gamma T06292 [1];
SF lacks transactivation (TA) domain [1];
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MX M00761 V$P53DECAMER_Q2.
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BS R26473.
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DR TRANSPATH: MO000043795.
DR EMBL: AF075439;
DR EMBL: AF533892; AF533892.
DR UniProtKB: O88898-2;
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RN [1]; RE0024981.
RX PUBMED: 10227294.
RA Yang A., Schweitzer R., Sun D., Kaghad M., Walker N., Bronson R. T., Tabin C., Sharpe A., Caput D., Crum C., McKeon F.
RT p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development.
RL Nature 398:714-718 (1999).
RN [2]; RE0049705.
RX PUBMED: 15908775.
RA Bakkers J., Camacho-Carvajal M., Nowak M., Kramer C., Danger B., Hammerschmidt M.
RT Destabilization of DeltaNp63alpha by Nedd4-mediated ubiquitination and Ubc9-mediated sumoylation, and its implications on dorsoventral patterning of the zebrafish embryo.
RL Cell Cycle 4:790-800 (2005).
RN [3]; RE0050255.
RX PUBMED: 16861923.
RA Rossi M., De Simone M., Pollice A., Santoro R., La Mantia G., Guerrini L., Calabro V.
RT Itch/AIP4 associates with and promotes p63 protein degradation.
RL Cell Cycle 5:1816-1822 (2006).
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