AC T00806
AS T00760.
XX
ID T00806
XX
DT 15.10.1992 (created); ewi.
DT 27.11.2015 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA TEF-1
XX
SY AA; FLJ17970; GT-IIC; MCBF; NTEF-1; REF1; Sph factor; TCF-13; TCF13; TEA domain family member 1 (SV40 transcriptional enhancer factor); TEAD-1; TEAD1; TEF-1; TEF1; transcriptional enhancer factor 1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004668 TEAD1; HGNC: TEAD1.
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HO AP-5.
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CL C0024; TEA; 3.6.1.0.1.
XX
SF translation start codon used in vivo is an AUU (Ile) codon [3];
SF the TEA domain comprises three putative alpha-helices, together with two additional regions required for DNA-binding [4] [8];
SF in the SV40 enhancer, TEF-1 binds to two distinct elements (GT-IIC, Sph) in a cooperative manner [2];
SF the C-terminal trans-activation domain is composed of (at least) eight cooperating parts [8];
XX
CP (HeLa).
CN lymphoid cells.
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FF activator;
FF function depends on a highly limiting cofactor [8] [3];
FF interactions between TEF-1 and TFIID can be inhibited by a B-cell specific factor [10];
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IN T01769 MEF-2C-isoform2; mouse, Mus musculus.
IN T25957 YAP-isoform1; human, Homo sapiens.
IN T25956 YAP-isoform2; human, Homo sapiens.
IN T22876 YAP; human, Homo sapiens.
XX
MX M04141 V$TEAD1_03.
MX M00704 V$TEF1_Q6.
MX M01817 V$TEF1_Q6_03.
MX M07340 V$TEF1_Q6_04.
MX M01305 V$TEF_01.
MX M07480 V$TEF_07.
XX
BS R70700.
BS R70701.
BS R70702.
BS R70703.
BS R70704.
BS R70705.
BS R70706.
BS R70707.
BS R70708.
BS R70709.
BS R70710.
BS R70711.
BS R70712.
BS R70713.
BS R70714.
BS R70715.
BS R70716.
BS R70717.
BS R70718.
BS R70719.
BS R70720.
BS R70721.
BS R70722.
BS R70723.
BS R70724.
BS R70725.
BS R70726.
BS R70727.
BS R70728.
BS R70729.
BS R70730.
BS R31133.
BS R31422.
BS R31423.
BS R31424.
BS R31425.
BS R31426.
BS R35630.
BS R02030.
BS R29458.
BS R31389.
BS R01236.
BS R31134.
BS R31407.
BS R31408.
BS R31135.
BS R03900.
BS R26314.
BS R01414.
BS R02250.
XX
DR TRANSPATH: MO000025182.
DR UniProtKB: P28347;
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RN [1]; RE0000071.
RX PUBMED: 2986843.
RA Emerson B. M., Lewis C. D., Felsenfeld G.
RT Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult beta-globin gene: nature of the binding domain
RL Cell 41:21-30 (1985).
RN [2]; RE0000125.
RX PUBMED: 2843293.
RA Davidson I., Xiao J. H., Rosales R., Staub A., Chambon P.
RT The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence
RL Cell 54:931-942 (1988).
RN [3]; RE0000183.
RX PUBMED: 1851669.
RA Xiao J. H., Davidson I., Matthes H., Garnier J.-M., Chambon P.
RT Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1
RL Cell 65:551-568 (1991).
RN [4]; RE0000256.
RX PUBMED: 2070413.
RA Buerglin T. R.
RT The TEA domain: a novel, highly conserved DNA-binding motif
RL Cell 66:11-12 (1991).
RN [5]; RE0000368.
RX PUBMED: 2826126.
RA Xiao J. H., Davidson I., Ferrandon D., Rosales R., Vigneron M., Macchi M., Ruffenach F., Chambon P.
RT One cell-specific and three ubiquitous proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer
RL EMBO J. 6:3005-3013 (1987).
RN [6]; RE0000404.
RX PUBMED: 2548845.
RA Mercurio F., Karin M.
RT Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner
RL EMBO J. 8:1455-1460 (1989).
RN [7]; RE0001261.
RX PUBMED: 3600658.
RA Kemper B., Jackson P. D., Felsenfeld G.
RT Protein-Binding Sites within the 5' DNase I-Hypersensitive Region of the Chicken alphaD-Globin Gene
RL Mol. Cell. Biol. 7:2059-2069 (1987).
RN [8]; RE0005291.
RX PUBMED: 8389695.
RA Hwang J.-J., Chambon P., Davidson I.
RT Characterization of the transcription activation function and the DNA binding domain of transcriptional enhancer factor-1
RL EMBO J. 12:2337-2348 (1993).
RN [9]; RE0005292.
RX PUBMED: 7958896.
RA Chen Z., Friedrich G. A., Soriano P.
RT Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice
RL Genes Dev. 8:2293-2301 (1994).
RN [10]; RE0005293.
RX PUBMED: 8035807.
RA Chaudhary S., Brou C., Valentin M.-E., Burton N., Tora L., Chambon P., Davidson I.
RT A cell-specific factor represses stimulation of transcription in vitro by transcriptional enhancer factor 1
RL Mol. Cell. Biol. 14:5290-5299 (1994).
RN [11]; RE0005294.
RX PUBMED: 8441689.
RA Blatt C., DePamphilis M. L.
RT Striking homology between the mouse and human transcriptional enhancer factor-1 (TEF-1)
RL Nucleic Acids Res. 21:747-748 (1993).
RN [12]; RE0005295.
RX PUBMED: 8106348.
RA Stewart A. F., Larkin S. B., Farrance I. K., Mar J. H., Hall D. E., Ordahl C. P.
RT Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription
RL J. Biol. Chem. 269:3147-3150 (1994).
RN [13]; RE0041339.
RX PUBMED: 12061776.
RA Maeda T., Gupta M. P., Stewart A. F.
RT TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters
RL Biochem. Biophys. Res. Commun. 294:791-7 (2002).
RN [14]; RE0071968.
RX PUBMED: 21205866.
RA Zhao B., Li L., Lu Q., Wang L. H., Liu C. Y., Lei Q., Guan K. L.
RT Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.
RL Genes Dev. 25:51-63 (2011).
RN [15]; RE0071974.
RX PUBMED: 21909427.
RA Wang P., Bai Y., Song B., Wang Y., Liu D., Lai Y., Bi X., Yuan Z.
RT PP1A-mediated dephosphorylation positively regulates YAP2 activity.
RL PLoS ONE 6:e24288 (2011).
RN [16]; RE0072967.
RX PUBMED: 21376238.
RA Schlegelmilch K., Mohseni M., Kirak O., Pruszak J., Rodriguez J. R., Zhou D., Kreger B. T., Vasioukhin V., Avruch J., Brummelkamp T. R., Camargo F. D.
RT Yap1 acts downstream of alpha-catenin to control epidermal proliferation.
RL Cell 144:782-795 (2011).
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