AC T34266
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ID T34266
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DT 05.04.2002 (created); mkl.
DT 10.02.2014 (updated); prb.
CO Copyright (C), QIAGEN.
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FA Rad51
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SY DNA repair protein Rad51.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006619 RAD51; HGNC: RAD51.
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IN T04074 brca1; human, Homo sapiens.
IN T06444 BRCA2; human, Homo sapiens.
IN T10012 BRCA2; human, Homo sapiens.
IN T34268 mcm3; human, Homo sapiens.
IN T18835 Mi2-alpha; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T34295 Rad51-isoform1; human, Homo sapiens.
IN T10717 RPA1; human, Homo sapiens.
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DR TRANSPATH: MO000030935.
DR UniProtKB: Q06609;
DR PDB: 1B22.
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RN [1]; RE0037755.
RX PUBMED: 15064730.
RA Yang Q., Zhang R., Wang X. W., Linke S. P., Sengupta S., Hickson I. D., Pedrazzi G., Perrera C., Stagljar I., Littman S. J., Modrich P., Harris C. C.
RT The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase
RL Oncogene 23:3749-56 (2004).
RN [2]; RE0048438.
RX PUBMED: 16141230.
RA Petkovic M., Dietschy T., Freire R., Jiao R., Stagljar I.
RT The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability.
RL J. Cell Sci. 118:4261-4269 (2005).
RN [3]; RE0048444.
RX PUBMED: 16920159.
RA Henson S. E., Tsai S. C., Malone C. S., Soghomonian S. V., Ouyang Y., Wall R., Marahrens Y., Teitell M. A.
RT Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks.
RL Mutat. Res. 601:113-124 (2006).
RN [4]; RE0048455.
RX PUBMED: 16428451.
RA Wesoly J., Agarwal S., Sigurdsson S., Bussen W., Van Komen S., Qin J., van Steeg H., van Benthem J., Wassenaar E., Baarends W. M., Ghazvini M., Tafel A. A., Heath H., Galjart N., Essers J., Grootegoed J. A., Arnheim N., Bezzubova O., Buerstedde J. M., Sung P., Kanaar R.
RT Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis.
RL Mol. Cell. Biol. 26:976-989 (2006).
RN [5]; RE0048467.
RX PUBMED: 15766559.
RA Shukla A., Navadgi V. M., Mallikarjuna K., Rao B. J.
RT Interaction of hRad51 and hRad52 with MCM complex: a cross-talk between recombination and replication proteins.
RL Biochem. Biophys. Res. Commun. 329:1240-1245 (2005).
RN [6]; RE0048468.
RX PUBMED: 8550550.
RA Shen Z., Cloud K. G., Chen D. J., Park M. S.
RT Specific interactions between the human RAD51 and RAD52 proteins.
RL J. Biol. Chem. 271:148-152 (1996).
RN [7]; RE0048505.
RX PUBMED: 9826763.
RA Golub E. I., Gupta R. C., Haaf T., Wold M. S., Radding C. M.
RT Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA.
RL Nucleic Acids Res. 26:5388-5393 (1998).
RN [8]; RE0048518.
RX PUBMED: 16395335.
RA Rodrigue A., Lafrance M., Gauthier M. C., McDonald D., Hendzel M., West S. C., Jasin M., Masson J. Y.
RT Interplay between human DNA repair proteins at a unique double-strand break in vivo.
RL EMBO J. 25:222-231 (2006).
RN [9]; RE0049002.
RX PUBMED: 16793542.
RA Xia B., Sheng Q., Nakanishi K., Ohashi A., Wu J., Christ N., Liu X., Jasin M., Couch F. J., Livingston D. M.
RT Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.
RL Mol. Cell 22:719-729 (2006).
RN [10]; RE0050588.
RX PUBMED: 14636569.
RA Dong Y., Hakimi M. A., Chen X., Kumaraswamy E., Cooch N. S., Godwin A. K., Shiekhattar R.
RT Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
RL Mol. Cell 12:1087-1099 (2003).
RN [11]; RE0052981.
RX PUBMED: 10373512.
RA Marston N. J., Richards W. J., Hughes D., Bertwistle D., Marshall C. J., Ashworth A.
RT Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.
RL Mol. Cell. Biol. 19:4633-4642 (1999).
RN [12]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
RN [13]; RE0064036.
RX PUBMED: 18449195.
RA Richard D. J., Bolderson E., Cubeddu L., Wadsworth R. I., Savage K., Sharma G. G., Nicolette M. L., Tsvetanov S., McIlwraith M. J., Pandita R. K., Takeda S., Hay R. T., Gautier J., West S. C., Paull T. T., Pandita T. K., White M. F., Khanna K. K.
RT Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.
RL Nature 453:677-681 (2008).
RN [14]; RE0068584.
RX PUBMED: 19584259.
RA Zhang F., Fan Q., Ren K., Andreassen P. R.
RT PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.
RL Mol. Cancer Res. 7:1110-1118 (2009).
RN [15]; RE0069452.
RX PUBMED: 21149733.
RA Gurvich N., Perna F., Farina A., Voza F., Menendez S., Hurwitz J., Nimer S. D.
RT L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability.
RL Proc. Natl. Acad. Sci. USA 107:22552-22557 (2010).
RN [16]; RE0021193.
RX PUBMED: 9008167.
RA Scully R., Chen J., Plug A., Xiao Y., Weaver D., Feunteun J., Ashley T., Livingston D. M.
RT Association of BRCA1 with Rad51 in mitotic and meiotic cells
RL Cell 88:265-275 (1997).
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