AC T08577
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ID T08577
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DT 17.02.2006 (created); elf.
DT 20.11.2006 (updated); res.
CO Copyright (C), QIAGEN.
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FA ZBRK1
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SY KRAB zinc finger protein ZFQR; ZBRK1; ZFQR; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; zinc finger protein 350; Zinc-finger protein ZBRK1; ZNF350.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G020729 ZNF350; HGNC: ZNF350.
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CL C0001; CH.
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SZ 532 AA; 59.9 kDa (cDNA) (calc.).
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SQ MIQAQESITLEDVAVDFTWEEWQLLGAAQKDLYRDVMLENYSNLVAVGYQASKPDALFKL
SQ EQGEQPWTIEDGIHSGACSDIWKVDHVLERLQSESLVNRRKPCHEHDAFENIVHCSKSQF
SQ LLGQNHDIFDLRGKSLKSNLTLVNQSKGYEIKNSVEFTGNGDSFLHANHERLHTAIKFPA
SQ SQKLISTKSQFISPKHQKTRKLEKHHVCSECGKAFIKKSWLTDHQVMHTGEKPHRCSLCE
SQ KAFSRKFMLTEHQRTHTGEKPYECPECGKAFLKKSRLNIHQKTHTGEKPYICSECGKGFI
SQ QKGNLIVHQRIHTGEKPYICNECGKGFIQKTCLIAHQRFHTGKTPFVCSECGKSCSQKSG
SQ LIKHQRIHTGEKPFECSECGKAFSTKQKLIVHQRTHTGERPYGCNECGKAFAYMSCLVKH
SQ KRIHTREKQEAAKVENPPAERHSSLHTSDVMQEKNSANGATTQVPSVAPQTSLNISGLLA
SQ NRNVVLVGQPVVRCAASGDNSGFAQDRNLVNAVNVVVPSVINYVLFYVTENP
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SC translated from EMBL:AF295096
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FT 6 47 
KRAB-A domain (Kruppel-associated box-zinc finger protein) [1].
FT 6 67 
KRAB domain (important for repression activity) [3].
FT 8 48 
PF01352; KRAB box.
FT 8 68 
SM00349; krabfinus.
FT 8 79 
PS50805; KRAB.
FT 48 67 
KRAB-B domain (Kruppel-associated box-zinc finger protein) [1].
FT 206 228 
PF00096; zf-C2H2.
FT 206 228 
SM00355; c2h2final6.
FT 206 233 
PS50157; ZINC_FINGER_C2H2_2.
FT 208 228 
C2H2 zinc finger 1 [3].
FT 234 256 PF00096; zf-C2H2.
FT 234 256 SM00355; c2h2final6.
FT 234 261 PS50157; ZINC_FINGER_C2H2_2.
FT 236 256 C2H2 zinc finger 2 [3].
FT 262 284 PF00096; zf-C2H2.
FT 262 284 SM00355; c2h2final6.
FT 262 289 PS50157; ZINC_FINGER_C2H2_2.
FT 264 284 C2H2 zinc finger 3 [3].
FT 290 312 PF00096; zf-C2H2.
FT 290 312 SM00355; c2h2final6.
FT 290 317 PS50157; ZINC_FINGER_C2H2_2.
FT 292 312 C2H2 zinc finger 4 [3].
FT 318 340 PF00096; zf-C2H2.
FT 318 340 SM00355; c2h2final6.
FT 318 345 PS50157; ZINC_FINGER_C2H2_2.
FT 320 340 C2H2 zinc finger 5 [3].
FT 346 368 PF00096; zf-C2H2.
FT 346 368 SM00355; c2h2final6.
FT 346 373 PS50157; ZINC_FINGER_C2H2_2.
FT 348 368 C2H2 zinc finger 6 [3].
FT 374 396 PF00096; zf-C2H2.
FT 374 396 SM00355; c2h2final6.
FT 374 401 PS50157; ZINC_FINGER_C2H2_2.
FT 376 396 C2H2 zinc finger 7 [3].
FT 402 424 PF00096; zf-C2H2.
FT 402 424 SM00355; c2h2final6.
FT 402 429 PS50157; ZINC_FINGER_C2H2_2.
FT 404 424 C2H2 zinc finger 8 [3].
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SF N-terminal KRAB domain and eight consecutive Krueppel-type C2H2 central zinc finger motifs [3];
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FF transcriptional repressor [3];
FF ZBRK1 binds to BRCA1 T04074 aa 341-748 [3];
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IN T04074 brca1; human, Homo sapiens.
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MX M01105 V$ZBRK1_01.
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BS R19100.
BS R18890.
BS R18891.
BS R18892.
BS R18893.
BS R18894.
BS R18895.
BS R18896.
BS R18897.
BS R18898.
BS R18899.
BS R18900.
BS R18901.
BS R18902.
BS R18903.
BS R18904.
BS R18905.
BS R18906.
BS R18908.
BS R19101.
BS R18907.
BS R19099.
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DR TRANSPATH: MO000075854.
DR EMBL: AF295096; AF295096.
DR UniProtKB: Q9GZX5; ZN350_HUMAN.
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RN [1]; RE0017949.
RX PUBMED: 12097288.
RA Peng H., Zheng L., Lee W. H., Rux J. J., Rauscher FJ 3. r. d.
RT A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1.
RL Cancer Res. 62:3773-3781 (2002).
RN [2]; RE0048799.
RX PUBMED: 14690447.
RA Surpili M. J., Delben T. M., Kobarg J.
RT Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.
RL Biochemistry 42:15369-15376 (2003).
RN [3]; RE0035939.
RX PUBMED: 11090615.
RA Zheng L., Pan H., Li S., Flesken-Nikitin A., Chen P. L., Boyer T. G., Lee W. H.
RT Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1.
RL Mol. Cell 6:757-768 (2000).
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