AC T01661
XX
ID T01661
XX
DT 06.02.1996 (created); ewi.
DT 21.11.2013 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA PR A
XX
SY NR3C3; NR3C3a; PR; progesterone receptor; progesterone receptor isoform A.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003936 PGR; HGNC: PGR.
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CL C0002; CC (rec); 2.1.1.1.3.1.
XX
SZ 769 AA; 82.4 kDa (cDNA) (calc.), 94 kDa (SDS)
XX
SQ MSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEE
SQ DSSESEESAGPLLKGKPRALGGAAAGGGAAACPPGAAAGGVALVPKEDSRFSAPRVALVE
SQ QDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRT
SQ SPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSY
SQ LVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYK
SQ AEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLG
SQ YQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTC
SQ GSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNK
SQ VRVVRALDAVALPQPLGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHD
SQ NTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLG
SQ WRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVL
SQ LLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLV
SQ KQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
XX
SC edited Swiss-Prot #P06401
XX
FT 1 400 
PF02161; Progesterone receptor.
FT 100 581 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 400 471 
SM00399; c4gold.
FT 400 475 
PS51030; NUCLEAR_REC_DBD_2.
FT 401 476 
PF00105; Zinc finger, C4 type (two domains).
FT 556 720 
SM00430; holi.
FT 559 744 
PF00104; Ligand-binding domain of nuclear hormon.
XX
SF alternative promoter usage and, concomitantly, alternative translation initiation gives rise to isoform B T00696 [2];
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FF both PR isoforms exhibit different promoter specificity [2];
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IN T08740 batf3; rat, Rattus norvegicus.
IN T18805 batf3; human, Homo sapiens.
IN T04074 brca1; human, Homo sapiens.
IN T06595 C/EBPbeta-FL; human, Homo sapiens.
IN T06596 C/EBPbeta-LIP; human, Homo sapiens.
IN T01487 cyclinA; human, Homo sapiens.
IN T02776 DAX1; human, Homo sapiens.
IN T00992 Hsp90; human, Homo sapiens.
IN T08741 jdp2; rat, Rattus norvegicus.
IN T19032 jdp2; human, Homo sapiens.
IN T00696 PR B; human, Homo sapiens.
IN T08891 PSF-isoform1; human, Homo sapiens.
IN T08171 PSF; human, Homo sapiens.
IN T04689 SMRT; human, Homo sapiens.
IN T19335 TIF1a-short; human, Homo sapiens.
XX
MX M00960 V$PR_Q2.
MX M03799 V$PR_Q6.
XX
BS R00973.
BS R00974.
BS R00975.
BS R00976.
BS R00978.
BS R14315.
BS R14316.
BS R12328.
BS R12329.
BS R34883.
BS R23811.
BS R02234.
BS R29385.
BS R34881.
XX
DR TRANSPATH: MO000021485.
DR UniProtKB: P06401-2;
XX
RN [1]; RE0000379.
RX PUBMED: 3416833.
RA Hecht A., Berkenstam A., Stroemstedt P.-E., Gustafsson J.-A., Sippel A. E.
RT A progesterone responsive element maps to the far upstream steroid DNase hypersensitive site of chicken lysozyme chromatin
RL EMBO J. 7:2063-2073 (1988).
RN [2]; RE0000463.
RX PUBMED: 2328727.
RA Kastner P., Krust A., Turcotte B., Stropp U., Tora L., Gronemeyer H., Chambon P.
RT Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B
RL EMBO J. 9:1603-1614 (1990).
RN [3]; RE0001752.
RX PUBMED: 2172797.
RA Forman B. M., Samuels H. H.
RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model
RL Mol. Endocrinol. 4:1293-1301 (1990).
RN [4]; RE0002418.
RX PUBMED: 1986383.
RA DeMarzo A. M., Beck C. A., Onate S. A., Edwards D. P.
RT Dimerization of mammalian progesterone receptors occurs in the absence of DNA and is related to the release of the 90-kDa heat shock protein
RL Proc. Natl. Acad. Sci. USA 88:72-76 (1991).
RN [5]; RE0003737.
RX PUBMED: 3283939.
RA Evans R. M.
RT The steroid and thyroid hormone receptor superfamily
RL Science 240:889-895 (1988).
RN [6]; RE0003738.
RX PUBMED: 1587864.
RA Meyer M.-E., Quirin-Stricker C., Lerouge T., Bocqel M.-T., Gronemeyer H.
RT A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms
RL J. Biol. Chem. 267:10882-10887 (1992).
RN [7]; RE0003739.
RX PUBMED: 1518826.
RA Rehberger P., Rexin M., Gehring U.
RT Heterotetrameric structure of the human progesterone receptor
RL Proc. Natl. Acad. Sci. USA 89:8001-8005 (1992).
RN [8]; RE0003740.
RX PUBMED: 1312348.
RA Edwards D. P., Estes P. A., Fadok V. A., Bona B. J., Onate S., Nordeen S. K., Welch W. J.
RT Heat shock alters the composition of the heteromeric steroid receptor complexes and enhances receptor activity in vivo
RL Biochemistry 31:2482-2491 (1992).
RN [9]; RE0003745.
RX PUBMED: 3551956.
RA Misrahi M., Atger M., D'Auriol L., Loosfelt H., Meriel C., Fridlansky F., Guichon-Mantel A., Galibert F., Milgrom E.
RT Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA. Biochem
RL Biochem. Biophys. Res. Commun. 143:740-748 (1987).
RN [10]; RE0003750.
RX PUBMED: 1730721.
RA Shemshedini L., Ji J., Brou C., Chambon P., Gronemeyer H.
RT In vivo acticity of the transcription activation functions of the progesterone receptor
RL J. Biol. Chem. 267:1834-1839 (1992).
RN [11]; RE0017308.
RX PUBMED: 9115274.
RA Thenot S., Henriquet C., Rochefort H., Cavailles V.
RT Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1
RL J. Biol. Chem. 272:12062-12068 (1997).
RN [12]; RE0030408.
RX PUBMED: 12771131.
RA Agoulnik I. U., Krause W. C., Bingman W. E. 3rd, Rahman H. T., Amrikachi M., Ayala G. E., Weigel N. L.
RT Repressors of androgen and progesterone receptor action.
RL J. Biol. Chem. 278:31136-48 (2003).
RN [13]; RE0044354.
RX PUBMED: 11773445.
RA Christian M., Pohnke Y., Kempf R., Gellersen B., Brosens J. J.
RT Functional association of PR and CCAAT/enhancer-binding protein beta isoforms: promoter-dependent cooperation between PR-B and liver-enriched inhibitory protein, or liver-enriched activatory protein and PR-A in human endometrial stromal cells
RL Mol. Endocrinol. 16:141-54 (2002).
RN [14]; RE0047476.
RX PUBMED: 12101239.
RA Wardell S. E., Boonyaratanakornkit V., Adelman J. S., Aronheim A., Edwards D. P.
RT Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator.
RL Mol. Cell. Biol. 22:5451-5466 (2002).
RN [15]; RE0047842.
RX PUBMED: 15668243.
RA Dong X., Shylnova O., Challis J. R., Lye S. J.
RT Identification and characterization of the protein-associated splicing factor as a negative co-regulator of the progesterone receptor.
RL J. Biol. Chem. 280:13329-13340 (2005).
RN [16]; RE0051005.
RX PUBMED: 16109739.
RA Ma Y., Katiyar P., Jones L. P., Fan S., Zhang Y., Furth P. A., Rosen E. M.
RT The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells.
RL Mol. Endocrinol. 20:14-34 (2006).
RN [17]; RE0053292.
RX PUBMED: 15601848.
RA Narayanan R., Adigun A. A., Edwards D. P., Weigel N. L.
RT Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator.
RL Mol. Cell. Biol. 25:264-277 (2005).
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