AC T06596
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ID T06596
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DT 20.05.2005 (created); oke.
DT 11.12.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA C/EBPbeta-LIP
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SY C/EBP-beta3; C/EBPbeta(p20); LIP; liver inhibitory protein; NF-IL6-3; NF-IL6-3 repressor form.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002899 CEBPB; HGNC: CEBPB.
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CL C0008; bZIP.
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SZ 147 AA; 15.9 kDa (cDNA) (calc.), 18kDa [3]
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SQ MAAGFPYALRAYLGYQAVPSGSSGSLSTSSSSSPPGTPSPADAKAPPTACYAGAAPAPSQ
SQ VKSKAKKTVDKHSDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVE
SQ QLSRELSTLRNLFKQLPEPLLASSGHC
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SC Swiss-Prot#P17676, edited
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FT 71 135 
SM00338; brlzneu.
FT 72 125 
PF07716; bZIP_2.
FT 73 136 
PS50217; BZIP.
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SF C/EBPbeta-LIP isoform results from the usage of an alternative initiation site at position 199 of the protein sequence of the NF-IL6-1 isoform;
SF sequence is identical to the C-terminal 147 AA of the NF-IL6-1 isoform [1];
SF one of the three forms encoded by the human CEBPbeta gene that result from the usage of different in frame AUGs of the same mRNA species [3];
SF the shortest form, lacks the transactivation domain [1] [3];
SF may dimerize with activator isoforms NF-IL6-1,2 and thus function as a repressor [1];
SF bZIP domain of C/EBPbeta-LIP is involved in direct interactions with c-Jun [1];
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FF repressor form [3];
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IN T05499 BAF47; human, Homo sapiens.
IN T05451 BRG1; human, Homo sapiens.
IN T01261 Brm; human, Homo sapiens.
IN T00337 GR-alpha; human, Homo sapiens.
IN T08321 p53-isoform1; human, Homo sapiens.
IN T08628 POU2F1; Mammalia.
IN T01661 PR A; human, Homo sapiens.
IN T00696 PR B; human, Homo sapiens.
IN T22463 SNF2H; human, Homo sapiens.
IN T22464 SNF2H; human, Homo sapiens.
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MX M00109 V$CEBPB_01.
MX M00117 V$CEBPB_02.
MX M07315 V$CEBPB_Q3.
MX M01896 V$CEBPB_Q6.
MX M00912 V$CEBP_Q2_01.
MX M00770 V$CEBP_Q3.
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BS R38635.
BS R57760.
BS R57763.
BS R57764.
BS R57852.
BS R34771.
BS R16777.
BS R57796.
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DR TRANSPATH: MO000054455.
DR TRANSCOMPEL: C00116.
DR TRANSCOMPEL: C00563.
DR UniProtKB: P17676-3;
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RN [1]; RE0004730.
RX PUBMED: 8264594.
RA Hsu W., Kerppola T. K., Chen P.-L., Curran T., Chen-Kiang S.
RT Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region
RL Mol. Cell. Biol. 14:268-276 (1994).
RN [2]; RE0006266.
RX PUBMED: 7935377.
RA Klampfer L., Lee T. H., Hsu W., Vilcek J., Chen-Kiang S.
RT NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1
RL Mol. Cell. Biol. 14:6561-6569 (1994).
RN [3]; RE0007308.
RX PUBMED: 8455626.
RA Hsu W., Chen-Kiang S.
RT Convergent regulation of NF-Il6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells
RL Mol. Cell. Biol. 13:2515-2523 (1993).
RN [4]; RE0044354.
RX PUBMED: 11773445.
RA Christian M., Pohnke Y., Kempf R., Gellersen B., Brosens J. J.
RT Functional association of PR and CCAAT/enhancer-binding protein beta isoforms: promoter-dependent cooperation between PR-B and liver-enriched inhibitory protein, or liver-enriched activatory protein and PR-A in human endometrial stromal cells
RL Mol. Endocrinol. 16:141-54 (2002).
RN [5]; RE0047933.
RX PUBMED: 10602039.
RA Hatada E. N., Chen-Kiang S., Scheidereit C.
RT Interaction and functional interference of C/EBPbeta with octamer factors in immunoglobulin gene transcription.
RL Eur. J. Immunol. 30:174-184 (2000).
RN [6]; RE0048275.
RX PUBMED: 16227626.
RA Schneider-Merck T., Pohnke Y., Kempf R., Christian M., Brosens J. J., Gellersen B.
RT Physical interaction and mutual transrepression between CCAAT/enhancer-binding protein beta and the p53 tumor suppressor.
RL J. Biol. Chem. 281:269-278 (2006).
RN [7]; RE0068544.
RX PUBMED: 18820298.
RA Wang W. L., Lee Y. C., Yang W. M., Chang W. C., Wang J. M.
RT Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription.
RL Nucleic Acids Res. 36:6066-6079 (2008).
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