AC T34269
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ID T34269
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DT 23.05.2006 (created); ran.
DT 10.07.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA NBS1
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SY AT-V1; AT-V2; ATV; Cell cycle regulatory protein p95; FLJ10155; MGC87362; NBN; NBS; NBS1; NIBRIN; Nijmegen breakage syndrome protein 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G032212 NBN; HGNC: NBN.
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IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T04074 brca1; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T33112 TRF2; human, Homo sapiens.
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DR TRANSPATH: MO000081816.
DR UniProtKB: O60934;
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RN [1]; RE0027653.
RX PUBMED: 10783165.
RA Wang Y., Cortez D., Yazdi P., Neff N., Elledge S. J., Qin J.
RT BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
RL Genes Dev. 14:927-39 (2000).
RN [2]; RE0030307.
RX PUBMED: 12773400.
RA Foray N., Marot D., Gabriel A., Randrianarison V., Carr A. M., Perricaudet M., Ashworth A., Jeggo P.
RT A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.
RL EMBO J. 22:2860-71 (2003).
RN [3]; RE0041985.
RX PUBMED: 15026416.
RA Cheng W. H., von Kobbe C., Opresko P. L., Arthur L. M., Komatsu K., Seidman M. M., Carney J. P., Bohr V. A.
RT Linkage between Werner syndrome protein and the Mre11 complex via Nbs1
RL J. Biol. Chem. 279:21169-76 (2004).
RN [4]; RE0047767.
RX PUBMED: 15734743.
RA Alt J. R., Bouska A., Fernandez M. R., Cerny R. L., Xiao H., Eischen C. M.
RT Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.
RL J. Biol. Chem. 280:18771-18781 (2005).
RN [5]; RE0050487.
RX PUBMED: 16452482.
RA Aglipay J. A., Martin S. A., Tawara H., Lee S. W., Ouchi T.
RT ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
RL J. Biol. Chem. 281:9710-9718 (2006).
RN [6]; RE0050647.
RX PUBMED: 16391231.
RA Greenberg R. A., Sobhian B., Pathania S., Cantor S. B., Nakatani Y., Livingston D. M.
RT Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.
RL Genes Dev. 20:34-46 (2006).
RN [7]; RE0053727.
RX PUBMED: 16377563.
RA Stucki M., Clapperton J. A., Mohammad D., Yaffe M. B., Smerdon S. J., Jackson S. P.
RT MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.
RL Cell 123:1213-1226 (2005).
RN [8]; RE0064036.
RX PUBMED: 18449195.
RA Richard D. J., Bolderson E., Cubeddu L., Wadsworth R. I., Savage K., Sharma G. G., Nicolette M. L., Tsvetanov S., McIlwraith M. J., Pandita R. K., Takeda S., Hay R. T., Gautier J., West S. C., Paull T. T., Pandita T. K., White M. F., Khanna K. K.
RT Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.
RL Nature 453:677-681 (2008).
RN [9]; RE0064397.
RX PUBMED: 17715134.
RA Lee A. Y., Liu E., Wu X.
RT The Mre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells.
RL J. Biol. Chem. 282:32243-32255 (2007).
RN [10]; RE0067646.
RX PUBMED: 20460517.
RA Cha H., Lowe J. M., Li H., Lee J. S., Belova G. I., Bulavin D. V., Fornace AJ J. r.
RT Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
RL Cancer Res. 70:4112-4122 (2010).
RN [11]; RE0067905.
RX PUBMED: 15916964.
RA Bhoumik A., Takahashi S., Breitweiser W., Shiloh Y., Jones N., Ronai Z.
RT ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.
RL Mol. Cell 18:577-587 (2005).
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