TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04683 XX ID T04683 XX DT 27.08.2001 (created); rio. DT 14.06.2016 (updated); ros. CO Copyright (C), QIAGEN. XX FA STAT5A XX SY Signal Transducer and Activator of Transcription 1; signal transducer and activator of transcription 5a; STAT5; STAT5A. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002606 STAT5A; HGNC: STAT5A. XX CL C0039; STAT; XX SF binds as homodimer and homotetramer to consensus GAS (interferon gamma-activated sequences) motifs TTC(T/C)N(G/A)GAA [1]; SF STAT5A tetramers bind to two tandem repeated GAS sites with an optimal spacing of 6 bp [1]; SF STAT5A binds to the beta-casein promoter as well as to the CIS promoter as a tetramer [3]; SF transactivation domain is necessary for interactions with Oct-1 [4]; XX FF activator; FF phosphorylated in response to cytokine induction; FF cooperates and forms a unique DNA-binding complex with Oct-1 [4]; FF mediates induction of the cyclin D1 gene by thrombopoietin (TPO) [4]; XX IN T04074 brca1; human, Homo sapiens. IN T06444 BRCA2; human, Homo sapiens. IN T34781 ErbB1; human, Homo sapiens. IN T02718 HIF2A; human, Homo sapiens. IN T00641 POU2F1-isoform1; human, Homo sapiens. IN T05351 PPARgamma; human, Homo sapiens. XX MX M00457 V$STAT5A_01. MX M00460 V$STAT5A_02. MX M00493 V$STAT5A_03. MX M00499 V$STAT5A_04. MX M07311 V$STAT5A_Q4. MX M01890 V$STAT5A_Q6. MX M00223 V$STAT_01. MX M00777 V$STAT_Q6. XX BS R14236. BS R15672. BS R15838. BS R14310. BS R14311. BS R26866. BS R71190. BS R30839. BS R16934. BS R24153. BS R19772. BS R11154. BS R11155. BS R72060. BS R13215. BS R65325. BS R65326. BS R65330. BS R65332. BS R16930. BS R13241. BS R73622. BS R62842. BS R25764. XX DR TRANSPATH: MO000013125. DR TRANSCOMPEL: C00312. DR TRANSCOMPEL: C00313. DR TRANSCOMPEL: C00424. DR TRANSCOMPEL: C00610. DR UniProtKB: P42229; XX RN [1]; RE0016782. RX PUBMED: 10594041. RA Soldaini E., John S., Moro S., Bollenbacher J., Schindler U., Leonard W. J. RT DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites. RL Mol. Cell. Biol. 20:389-401 (2000). RN [2]; RE0019120. RX PUBMED: 7719937. RA HOU J., SCHINDLER U., HENZEL W.J., WONG S.C., MCKNIGHT S.L. RT Identification and purification of human Stat proteins activated in response to interleukin-2. RL Immunity 2:321-329 (1995). RN [3]; RE0023467. RX PUBMED: 9742102. RA Verdier F., Rabionet R., Gouilleux F., Beisenherz-Huss C., Varlet P., Muller O., Mayeux P., Lacombe C., Gisselbrecht S., Chretien S. RT A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B. RL Mol. Cell. Biol. 18:5852-5860 (1998). RN [4]; RE0024933. RX PUBMED: 14645506. RA Magne S., Caron S., Charon M., Rouyez M. C., Dusanter-Fourt I. RT STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression. RL Mol. Cell. Biol. 23:8934-8945 (2003). RN [5]; RE0028517. RX PUBMED: 9164861. RA Canbay E., Norman M., Kilic E., Goffin V., Zachary I. RT Prolactin stimulates the JAK2 and focal adhesion kinase pathways in human breast carcinoma T47-D cells. RL Biochem. J. 324:231-6 (1997). RN [6]; RE0039373. RX PUBMED: 11413148. RA Mahajan S., Vassilev A., Sun N., Ozer Z., Mao C., Uckun F. M. RT Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells RL J. Biol. Chem. 276:31216-28 (2001). RN [7]; RE0041352. RX PUBMED: 11254359. RA Ilan N., Cheung L., Miller S., Mohsenin A., Tucker A., Madri J. A. RT Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse RL Dev. Biol. 232:219-32 (2001). RN [8]; RE0050848. RX PUBMED: 12771142. RA Xi S., Zhang Q., Dyer K. F., Lerner E. C., Smithgall T. E., Gooding W. E., Kamens J., Grandis J. R. RT Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. RL J. Biol. Chem. 278:31574-31583 (2003). RN [9]; RE0052771. RX PUBMED: 11867689. RA Lehtonen A., Matikainen S., Miettinen M., Julkunen I. RT Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation. RL J. Leukoc. Biol. 71:511-519 (2002). RN [10]; RE0052908. RX PUBMED: 12459499. RA Vidarsson H., Mikaelsdottir E. K., Rafnar T., Bertwistle D., Ashworth A., Eyfjord J. E., Valgeirsdottir S. RT BRCA1 and BRCA2 bind Stat5a and suppress its transcriptional activity. RL FEBS Lett. 532:247-252 (2002). RN [11]; RE0055268. RX PUBMED: 17550976. RA Neilson L. M., Zhu J., Xie J., Malabarba M. G., Sakamoto K., Wagner K. U., Kirken R. A., Rui H. RT Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. RL Mol. Endocrinol. 21:2218-2232 (2007). RN [12]; RE0055576. RX PUBMED: 18089573. RA Tanimoto A., Murata Y., Wang K. Y., Tsutsui M., Kohno K., Sasaguri Y. RT Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells. RL J. Biol. Chem. 283:4643-4651 (2008). RN [13]; RE0055719. RX PUBMED: 15528381. RA Stout B. A., Bates M. E., Liu L. Y., Farrington N. N., Bertics P. J. RT IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils. RL J. Immunol. 173:6409-6417 (2004). RN [14]; RE0064175. RX PUBMED: 16139998. RA Robledo T., Arriaga-Pizano L., Lopez-Perez M., Salazar E. P. RT Type IV collagen induces STAT5 activation in MCF7 human breast cancer cells. RL Matrix Biol. 24:469-477 (2005). RN [15]; RE0064288. RX PUBMED: 19104082. RA Sattler A., Wagner U., Rossol M., Sieper J., Wu P., Krause A., Schmidt W. A., Radmer S., Kohler S., Romagnani C., Thiel A. RT Cytokine-induced human IFN-gamma-secreting effector-memory Th cells in chronic autoimmune inflammation. RL Blood 113:1948-1956 (2009). RN [16]; RE0064848. RX PUBMED: 18071309. RA Tao W. J., Lin H., Sun T., Samanta A. K., Arlinghaus R. RT BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor. RL Oncogene 27:3194-3200 (2008). RN [17]; RE0064946. RX PUBMED: 18955562. RA Pecaric-Petkovic T., Didichenko S. A., Kaempfer S., Spiegl N., Dahinden C. A. RT Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. RL Blood 113:1526-1534 (2009). RN [18]; RE0066373. RX PUBMED: 11245630. RA Bhattacharya S., Stout B. A., Bates M. E., Bertics P. J., Malter J. S. RT Granulocyte macrophage colony-stimulating factor and interleukin-5 activate STAT5 and induce CIS1 mRNA in human peripheral blood eosinophils. RL Am. J. Respir. Cell Mol. Biol. 24:312-316 (2001). RN [19]; RE0067006. RX PUBMED: 16556602. RA Gorska M. M., Cen O., Liang Q., Stafford S. J., Alam R. RT Differential regulation of interleukin 5-stimulated signaling pathways by dynamin. RL J. Biol. Chem. 281:14429-14439 (2006). RN [20]; RE0069503. RX PUBMED: 20974963. RA Rochman Y., Kashyap M., Robinson G. W., Sakamoto K., Gomez-Rodriguez J., Wagner K. U., Leonard W. J. RT Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. RL Proc. Natl. Acad. Sci. USA 107:19455-19460 (2010). RN [21]; RE0024707. RX PUBMED: 12060651. RA Chughtai N., Schimchowitsch S., Lebrun J. J., Ali S. RT Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells. RL J. Biol. Chem. 277:31107-31114 (2002). XX //