AC T02718
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ID T02718
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DT 04.05.1999 (created); ewi.
DT 16.04.2015 (updated); msr.
CO Copyright (C), QIAGEN.
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FA HIF2A
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SY bHLHe73; ECYT4; endothelial PAS domain protein 1; endothelial PAS-1; EPAS1; HIF-2alpha; HIF2A; Hlf; hypoxia inducible transcription factor 2alpha; member of PAS superfamily 2; MOP2; PASD2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004008 EPAS1; HGNC: EPAS1.
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CL C0010; bHLH; 1.2.5.1.7.
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SF heterodimerization with Arnt required for trans-activation [1];
SF no interaction with hsp90 [2];
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CP Human lung microvascular EC and Hep3B cells exposed to hypoxia (0% oxygen) [3].
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [1].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [1].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [1].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [1].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; none; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; none; Northern blot; mRNA (poly-A); [2].
EX heart,,,adult; very high; Northern blot; mRNA (poly-A); [2].
EX kidney (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [2].
EX liver,,,adult; none; Northern blot; mRNA (poly-A); [2].
EX lung (right and left),,,adult; very high; Northern blot; mRNA (poly-A); [2].
EX muscles,,,adult; low; Northern blot; mRNA (poly-A); [2].
EX pancreas,,,adult; low; Northern blot; mRNA (poly-A); [2].
EX placenta,,,adult; very high; Northern blot; mRNA (poly-A); [2].
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FF Differentially regulated within human lung microvascular EC and Hep3B cells exposed to hypoxia (0% oxygen) [3];
FF strong activator, in particular under hypoxic conditions [1] [2];
FF may be a regulator of vascularization by regulating endothelial cell gene expression in response to hypoxia [1];
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IN T01346 arnt-isoform1; human, Homo sapiens.
IN T00250 Elk-1; human, Homo sapiens.
IN T08100 EWS; human, Homo sapiens.
IN T16713 MEF-2C; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
IN T04683 STAT5A; human, Homo sapiens.
IN T00878 USF2; human, Homo sapiens.
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MX M01249 V$HIF2A_01.
MX M07356 V$HIF2A_Q6.
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BS R65606.
BS R66957.
BS R65043.
BS R30529.
BS R73057.
BS R73060.
BS R73062.
BS R73063.
BS R73064.
BS R73065.
BS R56153.
BS R62003.
BS R62004.
BS R60749.
BS R64716.
BS R64717.
BS R64719.
BS R64728.
BS R65668.
BS R13214.
BS R66059.
BS R62537.
BS R66323.
BS R67086.
BS R10227.
BS R62005.
BS R28141.
BS R30398.
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DR TRANSPATH: MO000026694.
DR UniProtKB: Q99814;
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RN [1]; RE0013520.
RX PUBMED: 9000051.
RA Tian H., McKnight S. L., Russel D. W.
RT Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
RL Genes Dev. 11:72-82 (1997).
RN [2]; RE0013592.
RX PUBMED: 9079689.
RA Hogenesch J. B., Chan W. K., Jackiw V. H., Brown R. C., Gu Y.-Z., Pray-Grant M., Perdew G. H., Bradfield C. A.
RT Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
RL J. Biol. Chem. 272:8581-8593 (1997).
RN [3]; RE0034396.
RX PUBMED: 12697324.
RA Graven K. K., Bellur D., Klahn B. D., Lowrey S. L., Amberger E.
RT HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells.
RL Biochim. Biophys. Acta 1626:10-18 (2003).
RN [4]; RE0055037.
RX PUBMED: 18000879.
RA Oeffner F., Moch C., Neundorf A., Hofmann J., Koch M., Grzeschik K. H.
RT Novel interaction partners of Bardet-Biedl syndrome proteins.
RL Cell Motil. Cytoskeleton 65:143-155 (2008).
RN [5]; RE0067598.
RX PUBMED: 18424433.
RA Miyauchi Y., Kato M., Tokunaga F., Iwai K.
RT The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.
RL J. Biol. Chem. 283:16622-16631 (2008).
RN [6]; RE0068903.
RX PUBMED: 19147576.
RA Aprelikova O., Pandolfi S., Tackett S., Ferreira M., Salnikow K., Ward Y., Risinger J. I., Barrett J. C., Niederhuber J.
RT Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response.
RL Cancer Res. 69:616-624 (2009).
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