TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T34034 XX ID T34034 XX DT 08.03.2001 (created); cch. DT 03.02.2015 (updated); spk. CO Copyright (C), QIAGEN. XX FA p21Cip1 XX SY CAP20; cdk-inhibiting protein 1; cdk-interacting protein 1; CDKN1; CDKN1A; CIP1; cyclin-dependent kinase (cdk)-inhibitor p21; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (p21, Cip1); MDA-6; melanoma differentiation associated protein 6; P21; p21Cip1; p21WAF-1; p21Waf1; SDI1; WAF1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001161 CDKN1A; HGNC: CDKN1A. XX CP Smad4 overexpressing Panc-1 and Capan-1 cells [6]. CN Smad4 overexpressing CFPac-1 cells [6]. EX heart,,,adult; detectable; Northern blot; RNA (undefined); [78]. EX lung (right and left),,,adult; detectable; Northern blot; RNA (undefined); [78]. EX muscles,,,adult; detectable; Northern blot; RNA (undefined); [78]. EX pancreas,,,adult; detectable; Northern blot; RNA (undefined); [78]. EX placenta,,,adult; detectable; Northern blot; RNA (undefined); [78]. XX FF ICI182,780, TSA, apicidin (HDAC inhibitor) and H. carbonumtoxin (HDAC inhibitor) treatment induces the expression [46]; XX IN T01488 Cdk2; human, Homo sapiens. IN T01487 cyclinA; human, Homo sapiens. IN T01376 E7; HPV-16, human papilloma virus type 16. IN T14055 PARP; human, Homo sapiens. IN T00722 pRb; human, Homo sapiens. IN T01493 STAT3; human, Homo sapiens. IN T30113 Trx1; human, Homo sapiens. XX DR TRANSPATH: MO000020561. DR UniProtKB: P38936; XX RN [1]; RE0017740. RX PUBMED: 9694869. RA Bellido T., O'Brien C. A., Roberson P. K., Manolagas S. C. RT Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells. RL J. Biol. Chem. 273:21137-21144 (1998). RN [2]; RE0021333. RX PUBMED: 11099484. RA Genini D., Sheeter D., Rought S., Zaunders J. J., Susin S. A., Kroemer G., Richman D. D., Carson D. A., Corbeil J., Leoni L. M. RT HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism RL FASEB J. 15:5-6 (2001). RN [3]; RE0022712. RX PUBMED: 11404460. RA Lin H. K., Yeh S., Kang H. Y., Chang C. RT Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. RL Proc. Natl. Acad. Sci. USA 98:7200-7205 (2001). RN [4]; RE0026903. RX PUBMED: 9652748. RA Fiddes R. J., Janes P. W., Sivertsen S. P., Sutherland R. L., Musgrove E. A., Daly R. J. RT Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells. RL Oncogene 16:2803-13 (1998). RN [5]; RE0027298. RX PUBMED: 10973963. RA Yang Q., Manicone A., Coursen J. D., Linke S. P., Nagashima M., Forgues M., Wang X. W. RT Identification of a functional domain in a GADD45-mediated G2/M checkpoint RL J. Biol. Chem. 275:36892-8 (2000). RN [6]; RE0030216. RX PUBMED: 12429655. RA Peng B., Fleming J. B., Breslin T., Grau A. M., Fojioka S., Abbruzzese J. L., Evans D. B., Ayers D., Wathen K., Wu T., Robertson K. D., Chiao P. J. RT Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. RL Clin. Cancer Res. 8:3628-38 (2002). RN [7]; RE0030982. RX PUBMED: 15084259. RA Seoane J., Le H. V., Shen L., Anderson S. A., Massague J. RT Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. RL Cell 117:211-23 (2004). RN [8]; RE0037868. RX PUBMED: 10574984. RA Rich J. N., Zhang M., Datto M. B., Bigner D. D., Wang X. F. RT Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines RL J. Biol. Chem. 274:35053-8 (1999). RN [9]; RE0047065. RX PUBMED: 12359750. RA Azzam E. I., de Toledo S. M., Spitz D. R., Little J. B. RT Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures RL Cancer Res. 62:5436-42 (2002). RN [10]; RE0047502. RX PUBMED: 16024799. RA Pedeux R., Sengupta S., Shen J. C., Demidov O. N., Saito S., Onogi H., Kumamoto K., Wincovitch S., Garfield S. H., McMenamin M., Nagashima M., Grossman S. R., Appella E., Harris C. C. RT ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. RL Mol. Cell. Biol. 25:6639-6648 (2005). RN [11]; RE0047563. RX PUBMED: 15053880. RA Li M., Brooks C. L., Kon N., Gu W. RT A dynamic role of HAUSP in the p53-Mdm2 pathway. RL Mol. Cell 13:879-886 (2004). RN [12]; RE0047581. RX PUBMED: 16055726. RA Kulikov R., Boehme K. A., Blattner C. RT Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance. RL Mol. Cell. Biol. 25:7170-7180 (2005). RN [13]; RE0047639. RX PUBMED: 12068014. RA Jin Y., Zeng S. X., Dai M. S., Yang X. J., Lu H. RT MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation. RL J. Biol. Chem. 277:30838-30843 (2002). RN [14]; RE0047812. RX PUBMED: 15456759. RA Jowsey P. A., Doherty A. J., Rouse J. RT Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. RL J. Biol. Chem. 279:55562-55569 (2004). RN [15]; RE0047884. RX PUBMED: 14525983. RA Wu K., Yang Y., Wang C., Davoli M. A., D'Amico M., Li A., Cveklova K., Kozmik Z., Lisanti M. P., Russell R. G., Cvekl A., Pestell R. G. RT DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. RL J. Biol. Chem. 278:51673-51684 (2003). RN [16]; RE0048079. RX PUBMED: 12522211. RA Liu L., Rodriguez-Belmonte E. M., Mazloum N., Xie B., Lee M. Y. RT Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. RL J. Biol. Chem. 278:10041-10047 (2003). RN [17]; RE0048080. RX PUBMED: 12930846. RA Frouin I., Maga G., Denegri M., Riva F., Savio M., Spadari S., Prosperi E., Scovassi A. I. RT Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners. RL J. Biol. Chem. 278:39265-39268 (2003). RN [18]; RE0048218. RX PUBMED: 16226712. RA Niture S. K., Doneanu C. E., Velu C. S., Bailey N. I., Srivenugopal K. S. RT Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. RL Biochem. Biophys. Res. Commun. 337:1176-1184 (2005). RN [19]; RE0048288. RX PUBMED: 14523002. RA Watcharasit P., Bijur G. N., Song L., Zhu J., Chen X., Jope R. S. RT Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53. RL J. Biol. Chem. 278:48872-48879 (2003). RN [20]; RE0048643. RX PUBMED: 11389691. RA Huang DY Chang ZF. RT Interaction of human thymidine kinase 1 with p21(Waf1). RL Biochem. J. 356:829 (2001). RN [21]; RE0048840. RX PUBMED: 15684379. RA Korgaonkar C., Hagen J., Tompkins V., Frazier A. A., Allamargot C., Quelle F. W., Quelle D. E. RT Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function. RL Mol. Cell. Biol. 25:1258-1271 (2005). RN [22]; RE0048940. RX PUBMED: 16135794. RA Datta A., Sen J., Hagen J., Korgaonkar C. K., Caffrey M., Quelle D. E., Hughes D. E., Ackerson T. J., Costa R. H., Raychaudhuri P. RT ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF. RL Mol. Cell. Biol. 25:8024-8036 (2005). RN [23]; RE0048951. RX PUBMED: 16343435. RA Oh Y. T., Chun K. H., Oh J. I., Park J. A., Kim Y. U., Lee S. K. RT PKCdelta modulates p21WAF1/CIP1 ability to bind to Cdk2 during TNFalpha-induced apoptosis. RL Biochem. Biophys. Res. Commun. 339:1138-1147 (2006). RN [24]; RE0049005. RX PUBMED: 16037820. RA Fogal V., Hsieh J. K., Royer C., Zhong S., Lu X. RT Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315. RL EMBO J. 24:2768-2782 (2005). RN [25]; RE0049038. RX PUBMED: 15989956. RA Chen D., Kon N., Li M., Zhang W., Qin J., Gu W. RT ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. RL Cell 121:1071-1083 (2005). RN [26]; RE0049039. RX PUBMED: 16107876. RA Wang C., Ivanov A., Chen L., Fredericks W. J., Seto E., Rauscher FJ 3. r. d., Chen J. RT MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. RL EMBO J. 24:3279-3290 (2005). RN [27]; RE0049046. RX PUBMED: 16777994. RA Tyagi A., Singh R. P., Agarwal C., Agarwal R. RT Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. RL Carcinogenesis 27:2269-2280 (2006). RN [28]; RE0049133. RX PUBMED: 17110379. RA Tompkins V. S., Hagen J., Frazier A. A., Lushnikova T., Fitzgerald M. P., Tommaso A. D., Ladeveze V., Domann F. E., Eischen C. M., Quelle D. E. RT A novel nuclear interactor of ARF and Mdm2 (NIAM) that maintains chromosomal stability. RL J. Biol. Chem. 282:1322-1333 (2006). RN [29]; RE0049158. RX PUBMED: 16319895. RA Turnell A. S., Stewart G. S., Grand R. J., Rookes S. M., Martin A., Yamano H., Elledge S. J., Gallimore P. H. RT The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. RL Nature 438:690-695 (2005). RN [30]; RE0049260. RX PUBMED: 12101418. RA Lan K. H., Sheu M. L., Hwang S. J., Yen S. H., Chen S. Y., Wu J. C., Wang Y. J., Kato N., Omata M., Chang F. Y., Lee S. D. RT HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis. RL Oncogene 21:4801-4811 (2002). RN [31]; RE0049426. RX PUBMED: 10873631. RA Wang F., Yoshida I., Takamatsu M., Ishido S., Fujita T., Oka K., Hotta H. RT Complex formation between hepatitis C virus core protein and p21Waf1/Cip1/Sdi1. RL Biochem. Biophys. Res. Commun. 273:479-484 (2000). RN [32]; RE0049480. RX PUBMED: 11278402. RA Arima N., Kao C. Y., Licht T., Padmanabhan R., Sasaguri Y., Padmanabhan R. RT Modulation of cell growth by the hepatitis C virus nonstructural protein NS5A. RL J. Biol. Chem. 276:12675-12684 (2001). RN [33]; RE0049576. RX PUBMED: 16511572. RA Jin Y., Dai M. S., Lu S. Z., Xu Y., Luo Z., Zhao Y., Lu H. RT 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. RL EMBO J. 25:1207-1218 (2006). RN [34]; RE0049596. RX PUBMED: 15063116. RA Sarcar B., Ghosh A. K., Steele R., Ray R., Ray R. B. RT Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase. RL Virology 322:51-60 (2004). RN [35]; RE0049678. RX PUBMED: 15572666. RA Munarriz E., Barcaroli D., Stephanou A., Townsend P. A., Maisse C., Terrinoni A., Neale M. H., Martin S. J., Latchman D. S., Knight R. A., Melino G., De Laurenzi V. RT PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. RL Mol. Cell. Biol. 24:10593-10610 (2004). RN [36]; RE0049747. RX PUBMED: 15843377. RA Mayo L. D., Seo Y. R., Jackson M. W., Smith M. L., Rivera Guzman J., Korgaonkar C. K., Donner D. B. RT Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. RL J. Biol. Chem. 280:25953-25959 (2005). RN [37]; RE0049893. RX PUBMED: 16801388. RA Yim H., Hwang I. S., Choi J. S., Chun K. H., Jin Y. H., Ham Y. M., Lee K. Y., Lee S. K. RT Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells. RL J. Cell Biol. 174:77-88 (2006). RN [38]; RE0049999. RX PUBMED: 10518217. RA Shikama N., Lee C. W., France S., Delavaine L., Lyon J., Krstic-Demonacos M., La Thangue N. B. RT A novel cofactor for p300 that regulates the p53 response. RL Mol. Cell 4:365-376 (1999). RN [39]; RE0050056. RX PUBMED: 15965232. RA MacPartlin M., Zeng S., Lee H., Stauffer D., Jin Y., Thayer M., Lu H. RT p300 regulates p63 transcriptional activity. RL J. Biol. Chem. 280:30604-30610 (2005). RN [40]; RE0050074. RX PUBMED: 15723830. RA Hanamoto T., Ozaki T., Furuya K., Hosoda M., Hayashi S., Nakanishi M., Yamamoto H., Kikuchi H., Todo S., Nakagawara A. RT Identification of protein kinase A catalytic subunit beta as a novel binding partner of p73 and regulation of p73 function. RL J. Biol. Chem. 280:16665-16675 (2005). RN [41]; RE0050452. RX PUBMED: 17098746. RA Abida W. M., Nikolaev A., Zhao W., Zhang W., Gu W. RT FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. RL J. Biol. Chem. 282:1797-1804 (2007). RN [42]; RE0052419. RX PUBMED: 17468517. RA Saegusa M., Hashimura M., Kuwata T., Hamano M., Wani Y., Okayasu I. RT A functional role of Cdx2 in beta-catenin signaling during transdifferentiation in endometrial carcinomas. RL Carcinogenesis 28:1885-1892 (2007). RN [43]; RE0052968. RX PUBMED: 16173922. RA Wang J., He X., Luo Y., Yarbrough W. G. RT A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. RL Biochem. J. 393:489-501 (2006). RN [44]; RE0053030. RX PUBMED: 16014626. RA Han J., Tsukada Y., Hara E., Kitamura N., Tanaka T. RT Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. RL J. Biol. Chem. 280:31548-31556 (2005). RN [45]; RE0053140. RX PUBMED: 12154087. RA Hasan M. K., Yaguchi T., Sugihara T., Kumar P. K., Taira K., Reddel R. R., Kaul S. C., Wadhwa R. RT CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. RL J. Biol. Chem. 277:37765-37770 (2002). RN [46]; RE0053456. RX PUBMED: 15557281. RA Varshochi R., Halim F., Sunters A., Alao J. P., Madureira P. A., Hart S. M., Ali S., Vigushin D. M., Coombes R. C., Lam E. W. RT ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. RL J. Biol. Chem. 280:3185-3196 (2005). RN [47]; RE0055471. RX PUBMED: 19054766. RA Dhawan P., Weider R., Christakos S. RT CCAAT Enhancer-binding Protein {alpha} Is a Molecular Target of 1,25-Dihydroxyvitamin D3 in MCF-7 Breast Cancer Cells. RL J. Biol. Chem. 284:3086-3095 (2009). RN [48]; RE0055629. RX PUBMED: 17941827. RA Yang C., Klein E. A., Assoian R. K., Kazanietz M. G. RT Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1. RL Biochem. J. 410:167-175 (2008). RN [49]; RE0055691. RX PUBMED: 16861904. RA Garcia R., Franklin R. A., McCubrey J. A. RT Cell death of MCF-7 human breast cancer cells induced by EGFR activation in the absence of other growth factors. RL Cell Cycle 5:1840-1846 (2006). RN [50]; RE0058894. RX PUBMED: 11753650. RA Bren G. D., Solan N. J., Miyoshi H., Pennington K. N., Pobst L. J., Paya C. V. RT Transcription of the RelB gene is regulated by NF-kappaB. RL Oncogene 20:7722-7733 (2001). RN [51]; RE0062667. RX PUBMED: 17569660. RA Zhou Y., Zhong Y., Wang Y., Zhang X., Batista D. L., Gejman R., Ansell P. J., Zhao J., Weng C., Klibanski A. RT Activation of p53 by MEG3 non-coding RNA. RL J. Biol. Chem. 282:24731-24742 (2007). RN [52]; RE0062791. RX PUBMED: 17698606. RA Tsang W. Y., Wang L., Chen Z., Sanchez I., Dynlacht B. D. RT SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression. RL J. Cell Biol. 178:621-633 (2007). RN [53]; RE0063318. RX PUBMED: 17916563. RA Jung H., Seong H. A., Ha H. RT NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function. RL J. Biol. Chem. 282:35293-35307 (2007). RN [54]; RE0063394. RX PUBMED: 18502749. RA Jung H., Seong H. A., Ha H. RT Critical role of cysteine residue 81 of macrophage migration inhibitory factor (MIF) in MIF-induced inhibition of p53 activity. RL J. Biol. Chem. 283:20383-20396 (2008). RN [55]; RE0063837. RX PUBMED: 17978094. RA Sakaguchi M., Sonegawa H., Murata H., Kitazoe M., Futami J., Kataoka K., Yamada H., Huh N. H. RT S100A11, an dual mediator for growth regulation of human keratinocytes. RL Mol. Biol. Cell 19:78-85 (2008). RN [56]; RE0064497. RX PUBMED: 18243116. RA Kitagawa M., Lee S. H., McCormick F. RT Skp2 suppresses p53-dependent apoptosis by inhibiting p300. RL Mol. Cell 29:217-231 (2008). RN [57]; RE0064643. RX PUBMED: 17684018. RA Selvendiran K., Tong L., Vishwanath S., Bratasz A., Trigg N. J., Kutala V. K., Hideg K., Kuppusamy P. RT EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. RL J. Biol. Chem. 282:28609-28618 (2007). RN [58]; RE0065167. RX PUBMED: 19377469. RA Tian C., Xing G., Xie P., Lu K., Nie J., Wang J., Li L., Gao M., Zhang L., He F. RT KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. RL Nat. Cell Biol. 11:580-591 (2009). RN [59]; RE0065678. RX PUBMED: 19287375. RA Fumagalli S., Di Cara A., Neb-Gulati A., Natt F., Schwemberger S., Hall J., Babcock G. F., Bernardi R., Pandolfi P. P., Thomas G. RT Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction. RL Nat. Cell Biol. 11:501-508 (2009). RN [60]; RE0065765. RX PUBMED: 19151705. RA Nishiyama M., Oshikawa K., Tsukada Y., Nakagawa T., Iemura S., Natsume T., Fan Y., Kikuchi A., Skoultchi A. I., Nakayama K. I. RT CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. RL Nat. Cell Biol. 11:172-182 (2009). RN [61]; RE0065790. RX PUBMED: 19182791. RA Oh Y. M., Kwon Y. E., Kim J. M., Bae S. J., Lee B. K., Yoo S. J., Chung C. H., Deshaies R. J., Seol J. H. RT Chfr is linked to tumour metastasis through the downregulation of HDAC1. RL Nat. Cell Biol. 11:295-302 (2009). RN [62]; RE0066070. RX PUBMED: 19243219. RA Bossuyt W., Kazanjian A., De Geest N., Van Kelst S., De Hertogh G., Geboes K., Boivin G. P., Luciani J., Fuks F., Chuah M., VandenDriessche T., Marynen P., Cools J., Shroyer N. F., Hassan B. A. RT Atonal homolog 1 is a tumor suppressor gene. RL PLoS Biol. 7:e39 (2009). RN [63]; RE0066278. RX PUBMED: 19098008. RA Murase D., Hachiya A., Amano Y., Ohuchi A., Kitahara T., Takema Y. RT The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling. RL J. Biol. Chem. 284:4343-4353 (2009). RN [64]; RE0066943. RX PUBMED: 15371445. RA Li A. L., Li H. Y., Jin B. F., Ye Q. N., Zhou T., Yu X. D., Pan X., Man J. H., He K., Yu M., Hu M. R., Wang J., Yang S. C., Shen B. F., Zhang X. M. RT A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis. RL J. Biol. Chem. 279:49251-49258 (2004). RN [65]; RE0067007. RX PUBMED: 19372587. RA Hawthorne V. S., Huang W. C., Neal C. L., Tseng L. M., Hung M. C., Yu D. RT ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. RL Mol. Cancer Res. 7:592-600 (2009). RN [66]; RE0067465. RX PUBMED: 20471636. RA Zhang C., Yuan X., Yue L., Fu J., Luo L., Yin Z. RT PIASy interacts with p73alpha and regulates cell cycle in HEK293 cells. RL Cell Immunol. 263:235-240 (2010). RN [67]; RE0067653. RX PUBMED: 20547751. RA Deisenroth C., Thorner A. R., Enomoto T., Perou C. M., Zhang Y. RT Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. RL Mol. Cell. Biol. 30:3981-3993 (2010). RN [68]; RE0067666. RX PUBMED: 15866171. RA Jones R. G., Plas D. R., Kubek S., Buzzai M., Mu J., Xu Y., Birnbaum M. J., Thompson C. B. RT AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. RL Mol. Cell 18:283-293 (2005). RN [69]; RE0068244. RX PUBMED: 20801098. RA Iwatani K., Fujimoto T., Ito T. RT Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3-p300 interaction. RL Biochem. Biophys. Res. Commun. 400:426-431 (2010). RN [70]; RE0068557. RX PUBMED: 18485870. RA Tang Y., Zhao W., Chen Y., Zhao Y., Gu W. RT Acetylation is indispensable for p53 activation. RL Cell 133:612-626 (2008). RN [71]; RE0068907. RX PUBMED: 19845689. RA Chatzinikolaou G., Nikitovic D., Berdiaki A., Zafiropoulos A., Katonis P., Karamanos N. K., Tzanakakis G. N. RT Heparin regulates colon cancer cell growth through p38 mitogen-activated protein kinase signalling. RL Cell Prolif. 43:9-18 (2010). RN [72]; RE0069100. RX PUBMED: 21075852. RA Kroczynska B., Joshi S., Eklund E. A., Verma A., Kotenko S. V., Fish E. N., Platanias L. C. RT Regulatory Effects of Ribosomal S6 Kinase 1 (RSK1) in IFN{lambda} Signaling. RL J. Biol. Chem. 286:1147-1156 (2011). RN [73]; RE0069411. RX PUBMED: 19011621. RA Jansson M., Durant S. T., Cho E. C., Sheahan S., Edelmann M., Kessler B., La Thangue N. B. RT Arginine methylation regulates the p53 response. RL Nat. Cell Biol. 10:1431-1439 (2008). RN [74]; RE0069452. RX PUBMED: 21149733. RA Gurvich N., Perna F., Farina A., Voza F., Menendez S., Hurwitz J., Nimer S. D. RT L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability. RL Proc. Natl. Acad. Sci. USA 107:22552-22557 (2010). RN [75]; RE0069832. RX PUBMED: 20096447. RA Yuan J., Luo K., Zhang L., Cheville J. C., Lou Z. RT USP10 regulates p53 localization and stability by deubiquitinating p53. RL Cell 140:384-396 (2010). RN [76]; RE0070488. RX PUBMED: 20554519. RA Sun X. X., Wang Y. G., Xirodimas D. P., Dai M. S. RT Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation. RL J. Biol. Chem. 285:25812-25821 (2010). RN [77]; RE0071921. RX PUBMED: 18321991. RA Kim W., Seok Kang Y., Soo Kim J., Shin N. Y., Hanks S. K., Song W. K. RT The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling. RL Mol. Biol. Cell 19:2135-2146 (2008). RN [78]; RE0021166. RX PUBMED: 10878006. RA Ono T., Kitaura H., Ugai H., Murata T., Yokoyama K. K., Iguchi-Ariga S. M., Ariga H. RT TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase RL J. Biol. Chem. 275:31145-31154 (2000). RN [79]; RE0021109. RX PUBMED: 11463845. RA Roessig L., Jadidi A. S., Urbich C., Badorff C., Zeiher A. M., Dimmeler S. RT Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells RL Mol. Cell. Biol. 21:5644-5657 (2001). XX //