AC T08700
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ID T08700
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DT 13.03.2006 (created); jag.
DT 02.06.2008 (updated); pwa.
CO Copyright (C), QIAGEN.
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FA XBP-1S
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SY Tax-responsive element-binding protein 5; X box-binding protein 1; XBP-1; XBP-1 spliced.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006882 XBP1; HGNC: XBP1.
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CL C0008; bZIP; 1.1.5.0.1.2.
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SZ 376 AA; 40.1 kDa (cDNA) (calc.).
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SQ MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARK
SQ RQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLR
SQ EKTHGLVVENQELRQRLGMDALVAEEEAEAKGNEVRPVAGSAESAAGAGPVVTPPEHLPM
SQ DSGGIDSSDSESDILLGILDNLDPVMFFKCPSPEPASLEELPEVYPEGPSSLPASLSLSV
SQ GTSSAKLEAINELIRFDHIYTKPLVLEIPSETESQANVVVKIEEAPLSPSENDHPEFIVS
SQ VKEEPVEDDLVPELGISNLLSSSHCPKPSSCLLDAYSDCGYGGSLSPFSDMSSLLGVNHS
SQ WEDTFANELFPQLISV
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SC translated from EMBL:AB076384
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FT 68 122 
PF07716; Basic region leucine zipper.
FT 68 132 
SM00338; brlzneu.
FT 70 133 
PS50217; BZIP.
FT 75 133 
bZIP domain [3].
FT 165 376 
unique to XBP-1S [3].
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FF suggested to function as a co-regulator to enhance ERa transcriptional activity in a ligand-independent manner [1];
FF does not bind to ER stress response element by itself [3];
FF splicing to this isoform is induced in response to endoplasmic reticulum (ER) stress [3];
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IN T00261 ER-alpha; human, Homo sapiens.
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MX M00538 V$HTF_01.
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DR TRANSPATH: MO000079048.
DR EMBL: AB076384; AB076384.
DR UniProtKB: P17861-2;
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RN [1]; RE0047405.
RX PUBMED: 12954762.
RA Ding L., Yan J., Zhu J., Zhong H., Lu Q., Wang Z., Huang C., Ye Q.
RT Ligand-independent activation of estrogen receptor alpha by XBP-1.
RL Nucleic Acids Res. 31:5266-5274 (2003).
RN [2]; RE0053052.
RX PUBMED: 16539657.
RA Kakiuchi C., Ishiwata M., Hayashi A., Kato T.
RT XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells.
RL J. Neurochem 97:545-555 (2006).
RN [3]; RE0028961.
RX PUBMED: 11779464.
RA Yoshida H., Matsui T., Yamamoto A., Okada T., Mori K.
RT XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.
RL Cell 107:881-91 (2001).
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