AC T22561
XX
ID T22561
XX
DT 18.04.2006 (created); lyn.
DT 29.04.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA STAT3{p}
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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IN T00261 ER-alpha; human, Homo sapiens.
XX
BS R66590.
BS R66591.
BS R66592.
BS R66192.
BS R67344.
BS R66408.
BS R66418.
BS R66422.
BS R36998.
BS R66311.
BS R67425.
BS R70148.
BS R58250.
XX
DR TRANSPATH: MO000080134.
XX
RN [1]; RE0047580.
RX PUBMED: 15728479.
RA Suh H. S., Kim M. O., Lee S. C.
RT Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt.
RL J. Immunol. 174:2712-2719 (2005).
RN [2]; RE0049596.
RX PUBMED: 15063116.
RA Sarcar B., Ghosh A. K., Steele R., Ray R., Ray R. B.
RT Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase.
RL Virology 322:51-60 (2004).
RN [3]; RE0050918.
RX PUBMED: 17054914.
RA Uotani S., Abe T., Yamaguchi Y.
RT Leptin activates AMP-activated protein kinase in hepatic cells via a JAK2-dependent pathway.
RL Biochem. Biophys. Res. Commun. 351:171-175 (2006).
RN [4]; RE0051886.
RX PUBMED: 17070988.
RA Motta M., Accornero P., Taulli R., Bernabei P., Desrivieres S., Baratta M.
RT Leptin enhances STAT-3 phosphorylation in HC11 cell line: effect on cell differentiation and cell viability.
RL Mol. Cell. Endocrinol. 263:149-155 (2007).
RN [5]; RE0054609.
RX PUBMED: 16322893.
RA Tang D., Sivko G. S., DeWille J. W.
RT Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors.
RL Breast Cancer Res. Treat. 95:161-170 (2006).
RN [6]; RE0055452.
RX PUBMED: 16061651.
RA Nishimoto A., Yu Y., Lu Z., Mao X., Ren Z., Watowich S. S., Mills G. B., Liao W. S., Chen X., Bast RC J. r., Luo R. Z.
RT A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells.
RL Cancer Res. 65:6701-6710 (2005).
RN [7]; RE0055524.
RX PUBMED: 16177113.
RA Tokumaru S., Sayama K., Shirakata Y., Komatsuzawa H., Ouhara K., Hanakawa Y., Yahata Y., Dai X., Tohyama M., Nagai H., Yang L., Higashiyama S., Yoshimura A., Sugai M., Hashimoto K.
RT Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37.
RL J. Immunol. 175:4662-4668 (2005).
RN [8]; RE0055538.
RX PUBMED: 17531096.
RA Berishaj M., Gao S. P., Ahmed S., Leslie K., Al-Ahmadie H., Gerald W. L., Bornmann W., Bromberg J. F.
RT Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.
RL Breast Cancer Res. 9:R32 (2007).
RN [9]; RE0060095.
RX PUBMED: 15950906.
RA Lo H. W., Hsu S. C., Ali-Seyed M., Gunduz M., Xia W., Wei Y., Bartholomeusz G., Shih J. Y., Hung M. C.
RT Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
RL Cancer Cell 7:575-589 (2005).
RN [10]; RE0062677.
RX PUBMED: 17921143.
RA Pilecka I., Patrignani C., Pescini R., Curchod M. L., Perrin D., Xue Y., Yasenchak J., Clark A., Magnone M. C., Zaratin P., Valenzuela D., Rommel C., Hooft van Huijsduijnen R.
RT Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.
RL J. Biol. Chem. 282:35405-35415 (2007).
RN [11]; RE0064975.
RX PUBMED: 19776010.
RA McGillicuddy F. C., Chiquoine E. H., Hinkle C. C., Kim R. J., Shah R., Roche H. M., Smyth E. M., Reilly M. P.
RT Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.
RL J. Biol. Chem. 284:31936-31944 (2009).
RN [12]; RE0068071.
RX PUBMED: 17449633.
RA Dambacher J., Beigel F., Seiderer J., Haller D., Goke B., Auernhammer C. J., Brand S.
RT Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease.
RL Gut 56:1257-1265 (2007).
RN [13]; RE0068191.
RX PUBMED: 19484147.
RA Neiva K. G., Zhang Z., Miyazawa M., Warner K. A., Karl E., Nor J. E.
RT Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling.
RL Neoplasia 11:583-593 (2009).
RN [14]; RE0068197.
RX PUBMED: 17519976.
RA Fan Y., Ye J., Shen F., Zhu Y., Yeghiazarians Y., Zhu W., Chen Y., Lawton M. T., Young W. L., Yang G. Y.
RT Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro.
RL J. Cereb. Blood Flow Metab. 28:90-98 (2008).
RN [15]; RE0068437.
RX PUBMED: 17054938.
RA Elliott J., Cayouette M., Gravel C.
RT The CNTF/LIF signaling pathway regulates developmental programmed cell death and differentiation of rod precursor cells in the mouse retina in vivo.
RL Dev. Biol. 300:583-598 (2006).
RN [16]; RE0069503.
RX PUBMED: 20974963.
RA Rochman Y., Kashyap M., Robinson G. W., Sakamoto K., Gomez-Rodriguez J., Wagner K. U., Leonard W. J.
RT Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
RL Proc. Natl. Acad. Sci. USA 107:19455-19460 (2010).
RN [17]; RE0069518.
RX PUBMED: 11314001.
RA Kuo M. L., Chuang S. E., Lin M. T., Yang S. Y.
RT The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6.
RL Oncogene 20:677-685 (2001).
RN [18]; RE0069750.
RX PUBMED: 11429412.
RA Wang L. H., Yang X. Y., Mihalic K., Xiao W., Li D., Farrar W. L.
RT Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3.
RL J. Biol. Chem. 276:31839-31844 (2001).
RN [19]; RE0069823.
RX PUBMED: 21258366.
RA Hsu J. M., Chen C. T., Chou C. K., Kuo H. P., Li L. Y., Lin C. Y., Lee H. J., Wang Y. N., Liu M., Liao H. W., Shi B., Lai C. C., Bedford M. T., Tsai C. H., Hung M. C.
RT Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.
RL Nat. Cell Biol. 13:174-181 (2011).
RN [20]; RE0070029.
RX PUBMED: 21325207.
RA Ahmad R., Rajabi H., Kosugi M., Joshi M. D., Alam M., Vasir B., Kawano T., Kharbanda S., Kufe D.
RT MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop.
RL Sci. Signal. 4:ra9 (2011).
RN [21]; RE0070259.
RX PUBMED: 21076058.
RA Yu R. Y., Gallagher G.
RT A naturally occurring, soluble antagonist of human IL-23 inhibits the development and in vitro function of human Th17 cells.
RL J. Immunol. 185:7302-7308 (2010).
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