TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01043 XX ID T01043 XX DT 21.02.1994 (created); ewi. DT 06.09.2015 (updated); hna. CO Copyright (C), QIAGEN. XX FA HSF2 XX SY heat shock (transcription) factor 2; HSF-2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003945 HSF2; HGNC: HSF2. XX CL C0050; HSF; XX FF activator [1]; FF induced by hemin [2] [4]; FF exists in two isoforms HSF2A and HSF2B [4]; FF both isoforms are ineffective activators in vitro under basal conditions [4]; FF HSF2A is strongly activated by heat shock [4]; FF HSF2 T01043 associates with HSF1 T01042 in vitro and in vivo, binding is enhanced by heat shock [4]; FF interacts with the PR65 (A) subunit of the protein phosphatase 2A (PP2A), HSF2 binding to PR65 blocks its interaction with the catalytic subunit, due to competition between HSF2 and catalytic subunit for the same binding site in PR65 [5]; FF induced by hemin, but not by heat shock in K562 cells [6]; FF activation and expression of HSF2 are specific for the erythroid properties of K562 cells [6]; XX IN T00261 ER-alpha; human, Homo sapiens. IN T10036 HSF1; human, Homo sapiens. IN T04941 Mel-18; human, Homo sapiens. XX MX M00147 V$HSF2_01. MX M01244 V$HSF2_02. MX M04009 V$HSF2_04. MX M07358 V$HSF2_Q6. XX BS R36632. BS R36633. BS R00762. BS R00763. BS R00764. BS R04287. BS R71659. BS R36895. BS R24469. BS R69528. BS R69540. BS R69541. BS R23120. XX DR TRANSPATH: MO000046011. DR UniProtKB: Q03933; HSF2_HUMAN. XX RN [1]; RE0002539. RX PUBMED: 1871106. RA Schuetz T. J., Gallo G. J., Sheldon L., Temps P., Kingston R. E. RT Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans RL Proc. Natl. Acad. Sci. USA 88:6911-6915 (1991). RN [2]; RE0003104. RX PUBMED: 1508207. RA Sistonen L., Sarge K. D., Phillips B., Abravaya K., Morimoto R. I. RT Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells RL Mol. Cell. Biol. 12:4104-4111 (1992). RN [3]; RE0005280. RX PUBMED: 8421783. RA Rabindran S. K., Haroun R. I., Clos J., Wisniewski J., Wu C. RT Regulation of heat shock factor trimer formation: role of a conserved leucine zipper RL Science 259:230-234 (1993). RN [4]; RE0025006. RX PUBMED: 12813038. RA He H., Soncin F., Grammatikakis N., Li Y., Siganou A., Gong J., Brown S. A., Kingston R. E., Calderwood S. K. RT Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. RL J. Biol. Chem. 278:35465-35475 (2003). RN [5]; RE0025044. RX PUBMED: 10224043. RA Hong Y., Sarge K. D. RT Regulation of protein phosphatase 2A activity by heat shock transcription factor 2. RL J. Biol. Chem. 274:12967-12970 (1999). RN [6]; RE0025045. RX PUBMED: 10336892. RA Pirkkala L., Alastalo T. P., Nykanen P., Seppa L., Sistonen L. RT Differentiation lineage-specific expression of human heat shock transcription factor 2. RL FASEB J. 13:1089-1098 (1999). RN [7]; RE0071305. RX PUBMED: 18211895. RA Zhang J., Goodson M. L., Hong Y., Sarge K. D. RT MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation. RL J. Biol. Chem. 283:7464-7469 (2008). XX //