AC T04642
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ID T04642
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DT 26.07.2001 (created); dkl.
DT 20.05.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA SnoN
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SY SKI-like; SKIL.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006727 SKIL; HGNC: SKIL.
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FF in the absence of TGFbeta, SnoN binds to the nuclear Smad-4 and represses TGFbeta-responsive promoter activity through recruitment of a nuclear repressor complex [1];
FF TGFbeta induces activation and nuclear translocation of SMAD-2, SMAD-3 and SMAD-4 [1];
FF SMAD-3 causes degradation of SnoN, allowing a SMAD-2 and SMAD-4 complex to activate TGFbeta target genes [1];
FF SnoN maintains TGFbeta- repressed state of TGFbeta target genes in the absence of ligand and participates in the negative feed back regulation of TGFbeta signaling [1];
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IN T00261 ER-alpha; human, Homo sapiens.
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DR TRANSPATH: MO000028475.
DR UniProtKB: P12757;
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RN [1]; RE0016418.
RX PUBMED: 10531062.
RA Stroschein S. L., Wang W., Zhou S., Zhou Q., Luo K.
RT Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.
RL Science 286:771-774 (1999).
RN [2]; RE0049248.
RX PUBMED: 17202138.
RA Wrighton K. H., Liang M., Bryan B., Luo K., Liu M., Feng X. H., Lin X.
RT Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation.
RL J. Biol. Chem. 282:6517-6524 (2007).
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