TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04642 XX ID T04642 XX DT 26.07.2001 (created); dkl. DT 20.05.2014 (updated); spk. CO Copyright (C), QIAGEN. XX FA SnoN XX SY SKI-like; SKIL. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G006727 SKIL; HGNC: SKIL. XX FF in the absence of TGFbeta, SnoN binds to the nuclear Smad-4 and represses TGFbeta-responsive promoter activity through recruitment of a nuclear repressor complex [1]; FF TGFbeta induces activation and nuclear translocation of SMAD-2, SMAD-3 and SMAD-4 [1]; FF SMAD-3 causes degradation of SnoN, allowing a SMAD-2 and SMAD-4 complex to activate TGFbeta target genes [1]; FF SnoN maintains TGFbeta- repressed state of TGFbeta target genes in the absence of ligand and participates in the negative feed back regulation of TGFbeta signaling [1]; XX IN T00261 ER-alpha; human, Homo sapiens. XX DR TRANSPATH: MO000028475. DR UniProtKB: P12757; XX RN [1]; RE0016418. RX PUBMED: 10531062. RA Stroschein S. L., Wang W., Zhou S., Zhou Q., Luo K. RT Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. RL Science 286:771-774 (1999). RN [2]; RE0049248. RX PUBMED: 17202138. RA Wrighton K. H., Liang M., Bryan B., Luo K., Liu M., Feng X. H., Lin X. RT Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation. RL J. Biol. Chem. 282:6517-6524 (2007). XX //