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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T02143 XX ID T02143 XX DT 23.05.1997 (created); hiwi. DT 19.05.2006 (updated); jag. CO Copyright (C), QIAGEN. XX FA TIF1 XX SY TIF1; TIF1A; transcriptional intermediary factor 1; TRIM24; tripartite motif protein 24. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G014402 Trim24. XX SZ 1017 AA; 112.8 kDa (cDNA) (calc.). XX SQ MEVAVEKAAAAAAPAGGPAAAAPSGENEAESRQGPDSESGGEASRLNLLDTCAVCHQNIQ SQ SRVPKLLPCLHSFCQRCLPAPQRYLMLTAPALGSAETPPPAPAPAPAPGSPAGGPSPFAT SQ QVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV SQ EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDK SQ LTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKYTGNQIQNRIIEINQ SQ NQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM SQ HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNTTIQFHCDPSFWAQNIINL SQ GSLVIEDKESQPQMPKQNPVVEQSSQPPGGLPSNQLSKFPTQISLAQLRLQHIQQQHPPP SQ RLINFQNHSPKPNGPVLPPYPQQLRYSPSQNVPRQTTIKPNPLQMAFLAQQAIKQWQISS SQ VQAPPTTASSSSSTPSSPTITSAAGYDGKAFSSPMIDLSAPVGGSYNLPSLPDIDCSSTI SQ MLDNIARKDTGVDHAQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGS SQ RGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNT SQ NYPRSILTSLLLNSSQSSASEETVLRSDAPDSTGDQPGLHQENSSNGKSEWSDASQKSPV SQ HVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLTCHVPTLTNFPSGEWICTFCRDL SQ SKPEVDYDCDVPSHHSEKRKSEGLTKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVP SQ DYYKIIKNPMDLSTIKKRLQEDYCMYTKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKL SQ ESYFEELLKNLYPEKRFPKVEFRHEAEDCKFSDDSDDDFVQPRKKRLKSTEDRQLLK XX SC translated from EMBL #S78219 XX FT 52 130 PF00097; Zinc finger, C3HC4 type (RING finger). FT 52 130 SM00184; ring_2. FT 52 131 PS50089; ZF_RING_2. FT 141 474 PF00478; IMP dehydrogenase / GMP reductase domain. FT 158 205 SM00336; bboxneu5. FT 158 211 PS50119; ZF_BBOX. FT 160 205 PF00643; zf-B_box. FT 218 259 PS50119; ZF_BBOX. FT 218 259 SM00336; bboxneu5. FT 220 259 PF00643; zf-B_box. FT 266 392 SM00502; RAD_5. FT 793 840 PS50016; ZF_PHD_2. FT 795 838 SM00249; PHD_3. FT 795 840 PF00628; PHD-finger. FT 868 959 PF00439; Bromodomain. FT 868 973 SM00297; bromo_6. FT 899 954 PS50014; BROMODOMAIN_2. XX SF a putative splice variant is the 1051-AA form revealing a 34-AA insert after codon 476 [1]; SF no tight association with TFIID components or with TFIIB [1]; XX FF mediator, conferring the effect of the AF-2 domain of nuclear receptors [1]; XX IN T00261 ER-alpha; human, Homo sapiens. IN T00719 NR1B1-isoform1; human, Homo sapiens. IN T01345 RXR-alpha; human, Homo sapiens. IN T01333 RXR-gamma; mouse, Mus musculus. XX DR TRANSPATH: MO000026193. DR EMBL: S78219; DR UniProtKB: Q64127-2; XX RN [1]; RE0005634. RX PUBMED: 7744009. RA Le Douarin B., Zechel C., Garnier J.-M., Lutz Y., Tora L., Pierrat B., Heery D., Gronemeyer H., Chambon P., Losson R. RT The N-terminal part of TIF1, aputative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18 RL EMBO J. 14:2020-2033 (1995). RN [2]; RE0005635. RX PUBMED: 2205398. RA Tasset D., Tora L., Fromental C., Scheer E., Chambon P. RT Distinct classes of transcriptional activating domains function by different mechanisms RL Cell 62:1177-1187 (1990). XX //