AC T02143
XX
ID T02143
XX
DT 23.05.1997 (created); hiwi.
DT 19.05.2006 (updated); jag.
CO Copyright (C), QIAGEN.
XX
FA TIF1
XX
SY TIF1; TIF1A; transcriptional intermediary factor 1; TRIM24; tripartite motif protein 24.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G014402 Trim24.
XX
SZ 1017 AA; 112.8 kDa (cDNA) (calc.).
XX
SQ MEVAVEKAAAAAAPAGGPAAAAPSGENEAESRQGPDSESGGEASRLNLLDTCAVCHQNIQ
SQ SRVPKLLPCLHSFCQRCLPAPQRYLMLTAPALGSAETPPPAPAPAPAPGSPAGGPSPFAT
SQ QVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECV
SQ EWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDK
SQ LTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKYTGNQIQNRIIEINQ
SQ NQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM
SQ HFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNTTIQFHCDPSFWAQNIINL
SQ GSLVIEDKESQPQMPKQNPVVEQSSQPPGGLPSNQLSKFPTQISLAQLRLQHIQQQHPPP
SQ RLINFQNHSPKPNGPVLPPYPQQLRYSPSQNVPRQTTIKPNPLQMAFLAQQAIKQWQISS
SQ VQAPPTTASSSSSTPSSPTITSAAGYDGKAFSSPMIDLSAPVGGSYNLPSLPDIDCSSTI
SQ MLDNIARKDTGVDHAQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGS
SQ RGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNT
SQ NYPRSILTSLLLNSSQSSASEETVLRSDAPDSTGDQPGLHQENSSNGKSEWSDASQKSPV
SQ HVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLTCHVPTLTNFPSGEWICTFCRDL
SQ SKPEVDYDCDVPSHHSEKRKSEGLTKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVP
SQ DYYKIIKNPMDLSTIKKRLQEDYCMYTKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKL
SQ ESYFEELLKNLYPEKRFPKVEFRHEAEDCKFSDDSDDDFVQPRKKRLKSTEDRQLLK
XX
SC translated from EMBL #S78219
XX
FT 52 130 
PF00097; Zinc finger, C3HC4 type (RING finger).
FT 52 130 
SM00184; ring_2.
FT 52 131 
PS50089; ZF_RING_2.
FT 141 474 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 158 205 
SM00336; bboxneu5.
FT 158 211 
PS50119; ZF_BBOX.
FT 160 205 
PF00643; zf-B_box.
FT 218 259 
PS50119; ZF_BBOX.
FT 218 259 
SM00336; bboxneu5.
FT 220 259 
PF00643; zf-B_box.
FT 266 392 SM00502; RAD_5.
FT 793 840 PS50016; ZF_PHD_2.
FT 795 838 SM00249; PHD_3.
FT 795 840 PF00628; PHD-finger.
FT 868 959 PF00439; Bromodomain.
FT 868 973 SM00297; bromo_6.
FT 899 954 PS50014; BROMODOMAIN_2.
XX
SF a putative splice variant is the 1051-AA form revealing a 34-AA insert after codon 476 [1];
SF no tight association with TFIID components or with TFIIB [1];
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FF mediator, conferring the effect of the AF-2 domain of nuclear receptors [1];
XX
IN T00261 ER-alpha; human, Homo sapiens.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T01333 RXR-gamma; mouse, Mus musculus.
XX
DR TRANSPATH: MO000026193.
DR EMBL: S78219;
DR UniProtKB: Q64127-2;
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RN [1]; RE0005634.
RX PUBMED: 7744009.
RA Le Douarin B., Zechel C., Garnier J.-M., Lutz Y., Tora L., Pierrat B., Heery D., Gronemeyer H., Chambon P., Losson R.
RT The N-terminal part of TIF1, aputative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18
RL EMBO J. 14:2020-2033 (1995).
RN [2]; RE0005635.
RX PUBMED: 2205398.
RA Tasset D., Tora L., Fromental C., Scheer E., Chambon P.
RT Distinct classes of transcriptional activating domains function by different mechanisms
RL Cell 62:1177-1187 (1990).
XX
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