AC T08699
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ID T08699
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DT 13.03.2006 (created); jag.
DT 13.11.2006 (updated); kau.
CO Copyright (C), QIAGEN.
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FA XBP-1U
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SY Tax-responsive element-binding protein 5; TREB5; X box-binding protein 1; X-box binding protein 1; XBP-1; XBP-1 unspliced; XBP1; XBP2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006882 XBP1; HGNC: XBP1.
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CL C0008; bZIP; 1.1.5.0.1.1.
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SZ 261 AA; 28.7 kDa (cDNA) (calc.).
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SQ MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARK
SQ RQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLR
SQ EKTHGLVVENQELRQRLGMDALVAEEEAEAKGNEVRPVAGSAESAALRLRAPLQQVQAQL
SQ SPLQNISPWILAVLTLQIQSLISCWAFWTTWTQSCSSNALPQSLPAWRSSQRSTQKDPVP
SQ YQPPFLCQWGRHQPSWKPLMN
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SC translated from EMBL #AB076383
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FT 68 122 
PF07716; Basic region leucine zipper.
FT 68 132 
SM00338; brlzneu.
FT 70 133 
PS50217; BZIP.
FT 75 133 
bZIP domain [3].
FT 165 261 
unique to XBP-1U [3].
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FF suggested to function as a co-regulator to enhance ERa transcriptional activity in a ligand-independent manner [1];
FF does not bind to ER stress response element by itself [3];
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IN T09623 ATF-6; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T08699 XBP-1U; human, Homo sapiens.
IN T27866 Zhangfei; human, Homo sapiens.
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MX M00538 V$HTF_01.
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DR TRANSPATH: MO000079050.
DR EMBL: AB076383; AB076383.
DR UniProtKB: P17861-1;
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RN [1]; RE0047405.
RX PUBMED: 12954762.
RA Ding L., Yan J., Zhu J., Zhong H., Lu Q., Wang Z., Huang C., Ye Q.
RT Ligand-independent activation of estrogen receptor alpha by XBP-1.
RL Nucleic Acids Res. 31:5266-5274 (2003).
RN [2]; RE0048287.
RX PUBMED: 12805554.
RA Newman J. R., Keating A. E.
RT Comprehensive identification of human bZIP interactions with coiled-coil arrays.
RL Science 300:2097-2101 (2003).
RN [3]; RE0028961.
RX PUBMED: 11779464.
RA Yoshida H., Matsui T., Yamamoto A., Okada T., Mori K.
RT XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.
RL Cell 107:881-91 (2001).
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