AC T22422
XX
ID T22422
XX
DT 10.02.2006 (created); din.
DT 07.03.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA SRC3-xbb2
XX
SY ACTR; AIB-1; AIB1; Amplified in breast cancer-1 protein; CAGH16; CBP-interacting protein; CTG26; NCOA-3; NCOA3; nuclear receptor coactivator 3; p/CIP; pCIP; RAC-3; RAC3; Receptor-associated coactivator 3; SRC-3; SRC3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TNRC14; TNRC16; TRAM-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002759 NCOA3; HGNC: NCOA3.
XX
CL C0010; bHLH.
XX
SZ 1417 AA; 154.5 kDa (cDNA) (calc.).
XX
SQ MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
SQ NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
SQ LDGFLFVVNREANIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
SQ VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
SQ DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
SQ IQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDR
SQ HGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLA
SQ DPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNI
SQ MISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLST
SQ LSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKE
SQ SSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVS
SQ SSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGN
SQ VVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQE
SQ KDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLK
SQ SSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGS
SQ SMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPT
SQ LPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQV
SQ SHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPE
SQ LVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMN
SQ QMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTA
SQ GGAAVMRPMMQPQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQ
SQ QQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGR
SQ VSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQFAHQGNP
SQ AVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
XX
SC translated from EMBL:AF010227
XX
FT 15 83 
PS50888; HLH.
FT 28 83 
PF00010; Helix-loop-helix DNA-binding domain.
FT 31 88 
SM00353; finulus.
FT 55 1234 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 112 178 
SM00091; pas_2.
FT 117 180 
PS50112; PAS.
FT 1284 1341 
PF07469; Domain of unknown function (DUF1518).
XX
IN T10341 (VDR-isoform1)2; human, Homo sapiens.
IN T27166 BAF57; mouse, Mus musculus.
IN T09602 ER; Mammalia.
IN T05299 NR1B1; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T08431 PPARalpha; mouse, Mus musculus.
IN T08711 RelA-p65; human, Homo sapiens.
IN T17618 RXR-alpha:VDR-isoform1; human, Homo sapiens.
IN T08433 RXR-alpha; human, Homo sapiens.
IN T08264 T3R-beta; human, Homo sapiens.
IN T08482 VDR-isoform1; human, Homo sapiens.
IN T00885 VDR; human, Homo sapiens.
IN T09401 VDR; mouse, Mus musculus.
XX
DR TRANSPATH: MO000060381.
DR EMBL: AF010227; AF010227.
DR UniProtKB: Q9Y6Q9;
XX
RN [1]; RE0016497.
RX PUBMED: 9238002.
RA Li H., Gomes P. J., Chen J. D.
RT RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2
RL Proc. Natl. Acad. Sci. USA 94:8479-8484 (1997).
RN [2]; RE0031544.
RX PUBMED: 11250942.
RA Issa L. L., Leong G. M., Barry J. B., Sutherland R. L., Eisman J. A.
RT Glucocorticoid receptor-interacting protein-1 and receptor-associated coactivator-3 differentially interact with the vitamin D receptor (VDR) and regulate VDR-retinoid X receptor transcriptional cross-talk.
RL Endocrinology 142:1606-15 (2001).
RN [3]; RE0036142.
RX PUBMED: 12145209.
RA Belandia B., Orford R. L., Hurst H. C., Parker M. G.
RT Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes.
RL EMBO J. 21:4094-4103 (2002).
RN [4]; RE0051983.
RX PUBMED: 12529369.
RA Barry J. B., Leong G. M., Church W. B., Issa L. L., Eisman J. A., Gardiner E. M.
RT Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues.
RL J. Biol. Chem. 278:8224-8228 (2003).
XX
//