AC T08522
XX
ID T08522
XX
DT 02.02.2006 (created); jag.
CO Copyright (C), QIAGEN.
XX
FA HDAC4-isoform1
XX
SY AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDAC4; HDACA; histone deacetylase 4; KIAA0288.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G007850 HDAC4; HGNC: HDAC4.
XX
SZ 1084 AA; 119.0 kDa (cDNA) (calc.).
XX
SQ MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
SQ VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
SQ MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
SQ NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
SQ LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
SQ SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
SQ TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
SQ EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
SQ VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
SQ LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
SQ RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
SQ LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
SQ LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
SQ LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
SQ VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
SQ PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
SQ MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
SQ MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
SQ EPPL
XX
SC Swiss-Prot#P56524
XX
FT 1 208 
Targeting MEF2 to punctuate nuclear bodies [16].
FT 28 568 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 43 57 
CtBP binding domain [16].
FT 119 208 
HDAC1 binding domain [16].
FT 408 510 
HP1 binding domain [16].
FT 653 998 
PF00850; Histone deacetylase domain.
FT 803 846 
N-CoR/SMRT/HDAC3 binding domain [16].
XX
IN T03984 AML3-isoform1; human, Homo sapiens.
IN T34300 BCOR-isoform2; human, Homo sapiens.
IN T34301 BCOR-S; human, Homo sapiens.
IN T08291 GATA-1-isoform1; mouse, Mus musculus.
IN T08343 HDAC1; human, Homo sapiens.
IN T04110 HDAC3; human, Homo sapiens.
IN T09402 MEF-2C; Mammalia.
IN T09547 MEF-2C; mouse, Mus musculus.
IN T33892 MTA-1; Mammalia.
IN T08641 NCOR1-isoform1; mouse, Mus musculus.
IN T04687 NCOR1; human, Homo sapiens.
IN T05441 RFXANK; human, Homo sapiens.
IN T29717 SIRT1; human, Homo sapiens.
IN T04689 SMRT; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
XX
DR TRANSPATH: MO000059566.
DR EMBL: AF132607;
DR UniProtKB: P56524;
XX
RN [1]; RE0025804.
RX PUBMED: 14668799.
RA Watamoto K., Towatari M., Ozawa Y., Miyata Y., Okamoto M., Abe A., Naoe T., Saito H.
RT Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation.
RL Oncogene 22:9176-84 (2003).
RN [2]; RE0026599.
RX PUBMED: 10898795.
RA Huynh K. D., Fischle W., Verdin E., Bardwell V. J.
RT BCoR, a novel corepressor involved in BCL-6 repression.
RL Genes Dev. 14:1810-23 (2000).
RN [3]; RE0027552.
RX PUBMED: 10640275.
RA Huang E. Y., Zhang J., Miska E. A., Guenther M. G., Kouzarides T., Lazar M. A.
RT Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.
RL Genes Dev. 14:45-54 (2000).
RN [4]; RE0029293.
RX PUBMED: 11804585.
RA Fischle W., Dequiedt F., Hendzel M. J., Guenther M. G., Lazar M. A., Voelter W., Verdin E.
RT Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
RL Mol. Cell 9:45-57 (2002).
RN [5]; RE0047615.
RX PUBMED: 16051668.
RA Leong H., Sloan J. R., Nash P. D., Greene G. L.
RT Recruitment of histone deacetylase 4 to the N-terminal region of estrogen receptor alpha.
RL Mol. Endocrinol. 19:2930-2942 (2005).
RN [6]; RE0048077.
RX PUBMED: 15537544.
RA Vega R. B., Matsuda K., Oh J., Barbosa A. C., Yang X., Meadows E., McAnally J., Pomajzl C., Shelton J. M., Richardson J. A., Karsenty G., Olson E. N.
RT Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.
RL Cell 119:555-566 (2004).
RN [7]; RE0048095.
RX PUBMED: 15743821.
RA Micheli L., Leonardi L., Conti F., Buanne P., Canu N., Caruso M., Tirone F.
RT PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C.
RL Mol. Cell. Biol. 25:2242-2259 (2005).
RN [8]; RE0048124.
RX PUBMED: 16356933.
RA Gregoire S., Tremblay A. M., Xiao L., Yang Q., Ma K., Nie J., Mao Z., Wu Z., Giguere V., Yang X. J.
RT Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation.
RL J. Biol. Chem. 281:4423-4433 (2006).
RN [9]; RE0048453.
RX PUBMED: 12032081.
RA Kirsh O., Seeler J. S., Pichler A., Gast A., Muller S., Miska E., Mathieu M., Harel-Bellan A., Kouzarides T., Melchior F., Dejean A.
RT The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
RL EMBO J. 21:2682-2691 (2002).
RN [10]; RE0048484.
RX PUBMED: 10860984.
RA Wen Y. D., Perissi V., Staszewski L. M., Yang W. M., Krones A., Glass C. K., Rosenfeld M. G., Seto E.
RT The histone deacetylase-3 complex contains nuclear receptor corepressors.
RL Proc. Natl. Acad. Sci. USA 97:7202-7207 (2000).
RN [11]; RE0052069.
RX PUBMED: 12242305.
RA Zhang C. L., McKinsey T. A., Olson E. N.
RT Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation.
RL Mol. Cell. Biol. 22:7302-7312 (2002).
RN [12]; RE0052481.
RX PUBMED: 12590135.
RA Petrie K., Guidez F., Howell L., Healy L., Waxman S., Greaves M., Zelent A.
RT The histone deacetylase 9 gene encodes multiple protein isoforms.
RL J. Biol. Chem. 278:16059-16072 (2003).
RN [13]; RE0054734.
RX PUBMED: 18632985.
RA Wilson A. J., Byun D. S., Nasser S., Murray L. B., Ayyanar K., Arango D., Figueroa M., Melnick A., Kao G. D., Augenlicht L. H., Mariadason J. M.
RT HDAC4 promotes growth of colon cancer cells via repression of p21.
RL Mol. Biol. Cell 19:4062-4075 (2008).
RN [14]; RE0070855.
RX PUBMED: 18691969.
RA Knipscheer P., Flotho A., Klug H., Olsen J. V., van Dijk W. J., Fish A., Johnson E. S., Mann M., Sixma T. K., Pichler A.
RT Ubc9 sumoylation regulates SUMO target discrimination.
RL Mol. Cell 31:371-382 (2008).
RN [15]; RE0071301.
RX PUBMED: 17491593.
RA Knipscheer P., van Dijk W. J., Olsen J. V., Mann M., Sixma T. K.
RT Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation.
RL EMBO J. 26:2797-2807 (2007).
RN [16]; RE0048576.
RX PUBMED: 12709441.
RA Chan J. K., Sun L., Yang X. J., Zhu G., Wu Z.
RT Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity.
RL J. Biol. Chem. 278:23515-23521 (2003).
XX
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