AC T05288
AS T00013, T01182.
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ID T05288
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DT 21.10.2002 (created); oke.
DT 04.11.2014 (updated); asv.
CO Copyright (C), QIAGEN.
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FA HNF-4alpha
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SY AF-1; HNF4alpha.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004820 Hnf4a.
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CL C0002; CC (rec); 2.1.3.2.1.
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SF forms homodimers exclusively, does not form heterodimers with RARs, RXR-alpha, ARP-1, TR-alpha, VDR [7];
SF at least two splice variants are known: HNF-4alpha1 T00372, HNF-4alpha2 T02422;
SF located exclusively in the nucleus [7];
SF nuclear localization and DNA binding domains as well as the 272-353 region of HNF-4 are essential for its functional cooperation with SMAD-3:SMAD-4 [10];
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FF activator of liver-specific genes;
FF first, identified as a nuclear activity AF-1 activating apolipoprotein genes [4] [3] [2];
FF can functionally cooperate with SMAD-3/SMAD-4 and thus participate in TGFbeta induction of the ApoC3 promoter [10];
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IN T14594 ChREBP; rat, Rattus norvegicus.
IN T14067 FOXO1A; Mammalia.
IN T05288 HNF-4alpha; rat, Rattus norvegicus.
IN T10924 islet1; rat, Rattus norvegicus.
IN T02139 PC4; rat, Rattus norvegicus.
IN T05271 Smad3-isoform1:Smad4; human, Homo sapiens.
IN T04096 Smad3-isoform1; human, Homo sapiens.
IN T04292 Smad4; human, Homo sapiens.
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MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M07321 V$HNF4A_Q3.
MX M02016 V$HNF4A_Q6_01.
MX M00764 V$HNF4DR1_Q3.
MX M00134 V$HNF4_01.
MX M00411 V$HNF4_01_B.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
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BS R25058.
BS R00114.
BS R15841.
BS R15842.
BS R01612.
BS R25367.
BS R20739.
BS R02657.
BS R13058.
BS R19617.
BS R35003.
BS R19198.
BS R32875.
BS R15916.
BS R13034.
BS R13059.
BS R15921.
BS R13048.
BS R23481.
BS R60050.
BS R23140.
BS R23142.
BS R23143.
BS R14648.
BS R28982.
BS R63098.
BS R23144.
BS R23145.
BS R15891.
BS R16048.
BS R15940.
BS R15941.
BS R28979.
BS R28981.
BS R27924.
BS R13057.
BS R42179.
BS R32879.
BS R20724.
BS R23516.
BS R23518.
BS R41903.
BS R20866.
BS R42303.
BS R62804.
BS R21822.
BS R31339.
BS R31295.
BS R13067.
BS R18860.
BS R61292.
BS R03881.
BS R31284.
BS R19524.
BS R28985.
BS R64676.
BS R28984.
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DR TRANSPATH: MO000033895.
DR TRANSCOMPEL: C00651.
DR UniProtKB: P22449; HNF4_RAT.
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RN [1]; RE0000678.
RX PUBMED: 2279702.
RA Sladek F. M., Zhong W., Lai E., Darnell jr J. E.
RT Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
RL Genes Dev. 4:2353-2365 (1990).
RN [2]; RE0000898.
RX PUBMED: 2777781.
RA Leff T., Reue K., Melian A., Culver H., Breslow J. L.
RT A Regulatory Element in the ApoCIII Promoter That Directs Hepatic Specific Transcription Binds to Proteins in Expressing and Nonexpressing Cell Types
RL J. Biol. Chem. 264:16132-16137 (1989).
RN [3]; RE0001369.
RX PUBMED: 2325658.
RA Trus M., Benvenisty N., Cohen H., Reshef L.
RT Developmentally Regulated Interaction of Liver Nuclear Factors with the Rat Phosphoenolpyruvate Carboxykinase Promoter
RL Mol. Cell. Biol. 10:2418-2422 (1990).
RN [4]; RE0002747.
RX PUBMED: 2161847.
RA Metzger S., Leff T., Breslow J. L.
RT Nuclear factors AF-1 and C/EBP bind to the human ApoB gene promoter and modulate its transcriptional activity in hepatic cells
RL J. Biol. Chem. 265:9978-9983 (1990).
RN [5]; RE0006836.
RX PUBMED: 8657158.
RA Malik S., Karathanasis S. K.
RT TFIIB-directed transcriptional activation by the Orphan nuclear receptor hepatocyte nuclear factor 4
RL Mol. Cell. Biol. 16:1824-1831 (1996).
RN [6]; RE0007472.
RX PUBMED: 8344962.
RA Metzger S., Halaas J. L., Breslow J. L., Sladek F. M.
RT Orphan Receptor HNF-4 and bZip protein C/EBPalpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription
RL J. Biol. Chem. 268:16831- 16838 (1993).
RN [7]; RE0010683.
RX PUBMED: 7651430.
RA Jiang G., Nepomuceno L., Hopkins K., Sladek F. M.
RT Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors
RL Mol. Cell. Biol. 15:5131-5143 (1995).
RN [8]; RE0018053.
RX PUBMED: 11741883.
RA Guo H., Cai C. Q., Kuo P. C.
RT Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription.
RL J. Biol. Chem. 277:5054-5060 (2002).
RN [9]; RE0018068.
RX PUBMED: 11549270.
RA Nakabayashi H., Koyama Y., Sakai M., Li H. M., Wong N. C. W., Nishi S.
RT Glucocorticoid stimulates primate but inhibits rodent alpha-fetoprotein gene promoter.
RL Biochem. Biophys. Res. Commun. 287:160-172 (2001).
RN [10]; RE0018069.
RX PUBMED: 10995777.
RA Kardassis D., Pardali K., Zannis V. I.
RT SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4.
RL J. Biol. Chem. 275:41405-41414 (2000).
RN [11]; RE0018072.
RX PUBMED: 11110717.
RA Carew J. A., Pollak E. S., Lopaciuk S., Bauer K. A.
RT A new mutation in the HNF4 binding region of the factor VII promoter in a patient with severe factor VII deficiency.
RL Blood 96:4370-4372 (2000).
RN [12]; RE0048264.
RX PUBMED: 14530276.
RA Petrescu A. D., Payne H. R., Boedecker A., Chao H., Hertz R., Bar-Tana J., Schroeder F., Kier A. B.
RT Physical and functional interaction of Acyl-CoA-binding protein with hepatocyte nuclear factor-4 alpha.
RL J. Biol. Chem. 278:51813-51824 (2003).
RN [13]; RE0051630.
RX PUBMED: 12193589.
RA Dhe-Paganon S., Duda K., Iwamoto M., Chi Y. I., Shoelson S. E.
RT Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand.
RL J. Biol. Chem. 277:37973-37976 (2002).
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