AC T05271
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ID T05271
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DT 14.10.2002 (created); oke.
DT 24.05.2011 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Smad3-isoform1:Smad4
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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CL C0041; SMAD.
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SF heterodimer;
SF for individual polypeptides see human Smad-3 T04096 and human Smad-4 T04292;
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FF activates transcription by direct binding to DNA elements [2] [5];
FF may act as a co-activator and activate transcription through interactions with other DNA-binding TFs [3];
FF activates transcription in response to TGF-beta [2] [3];
FF cooperates with hypoxia-inducible factor HIF-1 and participates in the regulation of hypoxia-induced genes [5];
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IN T05220 Evi-1; human, Homo sapiens.
IN T01609 HIF-1; human, Homo sapiens.
IN T03828 HNF-4alpha; human, Homo sapiens.
IN T05288 HNF-4alpha; rat, Rattus norvegicus.
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MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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BS R10092.
BS R13585.
BS R73962.
BS R14158.
BS R30322.
BS R34710.
BS R13211.
BS R73964.
BS R13040.
BS R13041.
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DR TRANSPATH: MO000021176.
DR TRANSCOMPEL: C00194.
DR TRANSCOMPEL: C00195.
DR TRANSCOMPEL: C00196.
DR TRANSCOMPEL: C00197.
DR TRANSCOMPEL: C00199.
DR TRANSCOMPEL: C00371.
DR TRANSCOMPEL: C00395.
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RN [1]; RE0015727.
RX PUBMED: 9311995.
RA Nakao A., Imamura T., Souchelnytskyi S., Kawabata M., Ishisaki A., Oeda E., Tamaki K., Hanai J., Heldin C. H., Miyazono K., ten Dijke P.
RT TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
RL EMBO J. 16:5353-5362 (1997).
RN [2]; RE0016016.
RX PUBMED: 9043075.
RA Li H., Tierney C., Wen L., Wu J. Y., Rao Y.
RT A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate
RL Development 124:603-615 (1997).
RN [3]; RE0018069.
RX PUBMED: 10995777.
RA Kardassis D., Pardali K., Zannis V. I.
RT SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4.
RL J. Biol. Chem. 275:41405-41414 (2000).
RN [4]; RE0020494.
RX PUBMED: 11243848.
RA Goto D., Nakajima H., Mori Y., Kurasawa K., Kitamura N., Iwamoto I.
RT Interaction between Smad anchor for receptor activation and Smad3 is not essential for TGF-beta/Smad3-mediated signaling
RL Biochem. Biophys. Res. Commun. 281:1100-1105 (2001).
RN [5]; RE0022199.
RX PUBMED: 11486006.
RA Sanchez-Elsner T., Botella L. M., Velasco B., Corbi A., Attisano L., Bernabeu C.
RT Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression.
RL J. Biol. Chem. 276:38527-38535 (2001).
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