TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T05271 XX ID T05271 XX DT 14.10.2002 (created); oke. DT 24.05.2011 (updated); mkl. CO Copyright (C), QIAGEN. XX FA Smad3-isoform1:Smad4 XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX CL C0041; SMAD. XX SF heterodimer; SF for individual polypeptides see human Smad-3 T04096 and human Smad-4 T04292; XX FF activates transcription by direct binding to DNA elements [2] [5]; FF may act as a co-activator and activate transcription through interactions with other DNA-binding TFs [3]; FF activates transcription in response to TGF-beta [2] [3]; FF cooperates with hypoxia-inducible factor HIF-1 and participates in the regulation of hypoxia-induced genes [5]; XX IN T05220 Evi-1; human, Homo sapiens. IN T01609 HIF-1; human, Homo sapiens. IN T03828 HNF-4alpha; human, Homo sapiens. IN T05288 HNF-4alpha; rat, Rattus norvegicus. XX MX M00792 V$SMAD_Q6. MX M00974 V$SMAD_Q6_01. XX BS R10092. BS R13585. BS R73962. BS R14158. BS R30322. BS R34710. BS R13211. BS R73964. BS R13040. BS R13041. XX DR TRANSPATH: MO000021176. DR TRANSCOMPEL: C00194. DR TRANSCOMPEL: C00195. DR TRANSCOMPEL: C00196. DR TRANSCOMPEL: C00197. DR TRANSCOMPEL: C00199. DR TRANSCOMPEL: C00371. DR TRANSCOMPEL: C00395. XX RN [1]; RE0015727. RX PUBMED: 9311995. RA Nakao A., Imamura T., Souchelnytskyi S., Kawabata M., Ishisaki A., Oeda E., Tamaki K., Hanai J., Heldin C. H., Miyazono K., ten Dijke P. RT TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4 RL EMBO J. 16:5353-5362 (1997). RN [2]; RE0016016. RX PUBMED: 9043075. RA Li H., Tierney C., Wen L., Wu J. Y., Rao Y. RT A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate RL Development 124:603-615 (1997). RN [3]; RE0018069. RX PUBMED: 10995777. RA Kardassis D., Pardali K., Zannis V. I. RT SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4. RL J. Biol. Chem. 275:41405-41414 (2000). RN [4]; RE0020494. RX PUBMED: 11243848. RA Goto D., Nakajima H., Mori Y., Kurasawa K., Kitamura N., Iwamoto I. RT Interaction between Smad anchor for receptor activation and Smad3 is not essential for TGF-beta/Smad3-mediated signaling RL Biochem. Biophys. Res. Commun. 281:1100-1105 (2001). RN [5]; RE0022199. RX PUBMED: 11486006. RA Sanchez-Elsner T., Botella L. M., Velasco B., Corbi A., Attisano L., Bernabeu C. RT Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. RL J. Biol. Chem. 276:38527-38535 (2001). XX //