AC T01609
XX
ID T01609
XX
DT 24.01.1996 (created); ewi.
DT 05.02.2013 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA HIF-1
XX
SY HIF-1alpha(h):Arnt(h); HIF-1alpha:Arnt; HIF1; Hypoxia Induced Factor 1; hypoxia-inducible factor 1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
SF HIF-1 consists of two bHLH subunits, HIF-1alpha T01610 and HIF-1beta (Arnt) T01346 [1];
XX
FF activator [5];
FF may function as a repressor [6];
FF HIF-1 mediates gene responses to lowered oxygen levels (hypoxia, O2 demand exceeds supply) under which state the concentration of HIF-1 is increased [1];
FF HIF-1alpha, but not HIF-1beta, needs hypoxia for induction [4];
FF can functionally synergize with Smad-3/Smad-4 heterodimers [5];
XX
IN T05271 Smad3-isoform1:Smad4; human, Homo sapiens.
XX
MX M00976 V$AHRHIF_Q6.
MX M00797 V$HIF1_Q3.
MX M00466 V$HIF1_Q5.
XX
BS R10593.
BS R13359.
BS R14552.
BS R14551.
BS R10172.
BS R10594.
BS R10595.
BS R10596.
BS R13358.
BS R03219.
BS R13354.
BS R30385.
BS R74091.
BS R13356.
BS R13357.
BS R13220.
BS R13214.
BS R41639.
BS R18841.
BS R18842.
BS R18844.
BS R18845.
BS R18846.
BS R10395.
BS R10350.
BS R10227.
BS R30383.
BS R30398.
BS R10597.
BS R10599.
BS R13355.
BS R13291.
BS R35875.
XX
DR TRANSPATH: MO000025799.
DR TRANSCOMPEL: C00370.
DR TRANSCOMPEL: C00371.
DR TRANSCOMPEL: C00375.
DR TRANSCOMPEL: C00379.
DR TRANSCOMPEL: C00381.
XX
RN [1]; RE0003597.
RX PUBMED: 7539918.
RA Wang G. L., Jiang B.-H., Rue E. A., Semenza G. L.
RT Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
RL Proc. Natl. Acad. Sci. USA 92:5510-5514 (1995).
RN [2]; RE0013068.
RX PUBMED: 8816435.
RA Gradin K., Guire J., Wenger R. H., Kvietikova I., Whitelaw M. L., Toftgard R., Tora L., Gassmann M., Poellinger L.
RT Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor
RL Mol. Cell. Biol. 16:5221-5231 (1996).
RN [3]; RE0016733.
RX PUBMED: 7836384.
RA Wang G. L., Semenza G. L.
RT Purification and characterization of hypoxia-inducible factor 1.
RL J. Biol. Chem. 270:1230-1237 (1995).
RN [4]; RE0016776.
RX PUBMED: 8955077.
RA Semenza G. L., Jiang B. H., Leung S. W., Passantino R., Concordet J. P., Maire P., Giallongo A.
RT Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.
RL J. Biol. Chem. 271:32529-32537 (1996).
RN [5]; RE0022199.
RX PUBMED: 11486006.
RA Sanchez-Elsner T., Botella L. M., Velasco B., Corbi A., Attisano L., Bernabeu C.
RT Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression.
RL J. Biol. Chem. 276:38527-38535 (2001).
RN [6]; RE0022204.
RX PUBMED: 11390509.
RA Narravula S., Colgan S. P.
RT Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia.
RL J. Immunol. 166:7543-7548 (2001).
XX
//