AC T00019
AS T00195.
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ID T00019
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DT 25.01.1993 (created); hse.
DT 09.12.2011 (updated); spa.
CO Copyright (C), QIAGEN.
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FA AhR
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SY Ah receptor; AhR; aryl hydrocarbon receptor; dioxin receptor; XRE-binding factor.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005186 Ahr.
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CL C0010; bHLH; 1.2.5.1.1.
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SF 95 kDa: ligand-binding subunit;
SF Stokes radius: 7.0 nm;
SF dissociation into subunits upon treatment with 0.4 M KCl sedimenting with 4.9-5.6 S [4];
SF faster dissociation than murine complex [4];
SF interacts with hsp90 [5] [1];
SF DNA-binding of the heterodimer with Arnt is much stronger than that of Ahr homodimer [13];
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CP highest levels in liver, lower in thymus, kidney, lung [10].
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FF activator, binds to xenobiotic response element [8];
FF quickly up-regulated by aryl hydrocarbons (e.g. TCDD) within 30 min, down-regulated requiring an additional, labile factor over the subsequent 2 h [9];
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IN T00992 Hsp90; human, Homo sapiens.
IN T19201 pRb; rat, Rattus norvegicus.
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MX M00235 V$AHRARNT_01.
MX M00237 V$AHRARNT_02.
MX M00976 V$AHRHIF_Q6.
MX M00139 V$AHR_01.
MX M00778 V$AHR_Q5.
MX M01855 V$AHR_Q6.
MX M07347 V$AHR_Q6_01.
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BS R02117.
BS R02720.
BS R04653.
BS R04655.
BS R02651.
BS R29921.
BS R00270.
BS R13264.
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DR TRANSPATH: MO000024647.
DR UniProtKB: P41738;
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RN [1]; RE0000019.
RX PUBMED: 2844180.
RA Denis M., Cuthill S., Wikstroem A.-C., Poellinger L., Gustafsson J.-A.
RT Association of the dioxin receptor with the Mr 90.000 heat shock protein: a structural kinship with the glucocorticoid receptor
RL Biochem. Biophys. Res. Commun. 155:801-807 (1988).
RN [2]; RE0000879.
RX PUBMED: 2153679.
RA Nemoto T., Mason G. F., Wilhelmsson A., Cuthill S., Hapgood J., Gustafsson J. A., Poellinger L.
RT Activation of the Dioxin and Glucocorticoid Receptors to a DNA Binding State under Cell-free Conditions
RL J. Biol. Chem. 256:2269-2277 (1990).
RN [3]; RE0000990.
RX PUBMED: 2173716.
RA Elferink C. J., Gasiewicz T. A., Whitlock jr J. P.
RT Protein-DNA interactions at a dioxin-responsive enhancer
RL J. Biol. Chem. 265:20708-20712 (1990).
RN [4]; RE0001099.
RX PUBMED: 3005314.
RA Denison M. S., Vella L. M., Okeys A. B.
RT Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin
RL J. Biol. Chem. 261:3987-3995 (1986).
RN [5]; RE0001108.
RX PUBMED: 2843537.
RA Perdew G. H.
RT Association of the Ah receptor with the 90-kDa heat shock protein
RL J. Biol. Chem. 263:13802-13806 (1988).
RN [6]; RE0001109.
RX PUBMED: 3029114.
RA Cuthill S., Poellinger L., Gustafsson J.-A.
RT The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse hepatoma cell line Hepa 1c1c7
RL J. Biol. Chem. 262:3477-3481 (1987).
RN [7]; RE0002273.
RX PUBMED: 2833743.
RA Denison M. S., Fisher J. M., Whitlock jr J. P.
RT Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional activator
RL Proc. Natl. Acad. Sci. USA 85:2528-2532 (1988).
RN [8]; RE0002274.
RX PUBMED: 2536161.
RA Hapgood J., Cuthill S., Denis M., Poellinger L., Gustafsson J.-A.
RT Specific protein-DNA interactions at a xenobiotic-responsive element: Copurification of dioxin receptor and DNA-binding affinity
RL Proc. Natl. Acad. Sci. USA 86:60-64 (1989).
RN [9]; RE0003540.
RX PUBMED: 7891686.
RA Haas N. B., Cantwell C. A., Johnson P. F., Burch J. B. E.
RT DNA-binding specificity of the PAR basic leucine zipper protein VBP partially overlaps those of the C/EBP and CREB/ATF families and is influenced by domains that flank the core basic region
RL Mol. Cell. Biol. 15:1923-1932 (1995).
RN [10]; RE0004039.
RX PUBMED: 8065918.
RA Carver L. A., Hogenesch J. B., Bradfield C. A.
RT Tissue specific expression of the rat Ah-receptor and ARNT mRNAs
RL Nucleic Acids Res. 22:3038-3044 (1994).
RN [11]; RE0004040.
RX PUBMED: 8065302.
RA Reick M., Robertson R. W., Pasco D. S., Fagan J. B.
RT Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor
RL Mol. Cell. Biol. 14:5653-5660 (1994).
RN [12]; RE0004042.
RX PUBMED: 3588289.
RA Fujisawa-Sehara A., Sogawa K., Yamane M., Fuji-Kurijama Y.
RT Characterization of xenobiotic response elements upstream from the drug-metabolizing cytochrome P450c gene: a similarity to glucocorticoid regulatoty elements
RL Nucleic Acids Res. 15:4179-4191 (1987).
RN [13]; RE0005839.
RX PUBMED: 8308014.
RA Mason G. G. F., Witte A. M., Whitelaw M. L., Antonsson C., McGuire J., Wilhelmsson A., Poellinger L., Gustafsson J. A.
RT Purification of the DNA binding form of dioxin receptor
RL J. Biol. Chem. 269:4438-4449 (1994).
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