AC T08235
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ID T08235
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DT 27.09.2005 (created); sla.
DT 23.05.2016 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA PXR
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SY pregnane X receptor.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002752 Nr1i2.
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CL C0002; CC (rec); 2.1.2.4.2.
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IN T09104 FOXO1A; mouse, Mus musculus.
IN T01516 Pit-1B; rat, Rattus norvegicus.
IN T04689 SMRT; human, Homo sapiens.
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MX M00966 V$DR3_Q4.
MX M00965 V$DR4_Q2.
MX M07280 V$NR1NR2_Q3.
MX M00964 V$PXR_Q2.
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BS R28256.
BS R37148.
BS R14179.
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DR TRANSPATH: MO000056455.
DR UniProtKB: O54915; PXR_MOUSE.
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RN [1]; RE0023245.
RX PUBMED: 11248085.
RA Staudinger J. L., Goodwin B., Jones S. A., Hawkins-Brown D., MacKenzie K. I., LaTour A., Liu Y., Klaassen C. D., Brown K. K., Reinhard J., Willson T. M., Koller B. H., Kliewer S. A.
RT The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
RL Proc. Natl. Acad. Sci. USA 98:3369-3374 (2001).
RN [2]; RE0023316.
RX PUBMED: 12509506.
RA Goodwin B., Gauthier K. C., Umetani M., Watson M. A., Lochansky M. I., Collins J. L., Leitersdorf E., Mangelsdorf D. J., Kliewer S. A., Repa J. J.
RT Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.
RL Proc. Natl. Acad. Sci. USA 100:223-228 (2003).
RN [3]; RE0047375.
RX PUBMED: 11891224.
RA Gonzalez M. M., Carlberg C.
RT Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors.
RL J. Biol. Chem. 277:18501-18509 (2002).
RN [4]; RE0048304.
RX PUBMED: 15340055.
RA Kodama S., Koike C., Negishi M., Yamamoto Y.
RT Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.
RL Mol. Cell. Biol. 24:7931-7940 (2004).
RN [5]; RE0048421.
RX PUBMED: 16219912.
RA Johnson D. R., Li C. W., Chen L. Y., Ghosh J. C., Chen J. D.
RT Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).
RL Mol. Pharmacol. 69:99-108 (2006).
RN [6]; RE0051276.
RX PUBMED: 12569201.
RA Dussault I., Yoo H. D., Lin M., Wang E., Fan M., Batta A. K., Salen G., Erickson S. K., Forman B. M.
RT Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.
RL Proc. Natl. Acad. Sci. USA 100:833-838 (2003).
RN [7]; RE0051657.
RX PUBMED: 17456796.
RA Ricketts M. L., Boekschoten M. V., Kreeft A. J., Hooiveld G. J., Moen C. J., Muller M., Frants R. R., Kasanmoentalib S., Post S. M., Princen H. M., Porter J. G., Katan M. B., Hofker M. H., Moore D. D.
RT The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors.
RL Mol. Endocrinol. 21:1603-1616 (2007).
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