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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T08580 XX ID T08580 XX DT 20.02.2006 (created); kau. DT 17.07.2014 (updated); pos. CO Copyright (C), QIAGEN. XX FA STAT3-isoform1 XX SY acute-phase response factor; APRF; signal transducer and activator of transcription 3. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004610 STAT3; HGNC: STAT3. XX CL C0039; STAT; 6.2.1.0.3.1. XX SZ 770 AA; 88.0 kDa (cDNA) (calc.). XX SQ MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL SQ LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA SQ TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK SQ SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL SQ ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELHQKVSYKGDPIVQ SQ HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY SQ QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN SQ GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLSVVVISNICQMPNAWASILWY SQ NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS SQ GCQITWANFCKENMAGKGFSYWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST SQ KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM SQ DATNILLSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN SQ TIDLPMSPRALDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM XX SC translated from EMBL:L29277 XX FT 2 122 PF02865; STAT protein, protein interaction domain. FT 138 319 PF01017; STAT protein, all-alpha domain. FT 170 456 PF00478; IMP dehydrogenase / GMP reductase domain. FT 321 574 PF02864; STAT protein, DNA binding domain. FT 580 670 PS50001; SH2. FT 584 674 PF00017; SH2 domain. XX IN T04106 HDAC1; human, Homo sapiens. IN T08256 SRC-1A; human, Homo sapiens. XX MX M00225 V$STAT3_01. MX M00497 V$STAT3_02. MX M07065 V$STAT3_Q4. MX M00223 V$STAT_01. MX M00777 V$STAT_Q6. XX BS R22428. BS R22348. BS R22522. BS R22475. BS R14446. BS R14447. XX DR TRANSPATH: MO000078237. DR EMBL: L29277; DR UniProtKB: P40763-1; XX RN [1]; RE0029151. RX PUBMED: 11773079. RA Giraud S., Bienvenu F., Avril S., Gascan H., Heery D. M., Coqueret O. RT Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. RL J. Biol. Chem. 277:8004-11 (2002). RN [2]; RE0053305. RX PUBMED: 17909010. RA Lo H. W., Hsu S. C., Xia W., Cao X., Shih J. Y., Wei Y., Abbruzzese J. L., Hortobagyi G. N., Hung M. C. RT Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. RL Cancer Res. 67:9066-9076 (2007). RN [3]; RE0053916. RX PUBMED: 15313471. RA Palmer J., Hertzog P. J., Hammacher A. RT Differential expression and effects of gp130 cytokines and receptors in prostate cancer cells. RL Int. J. Biochem. Cell Biol. 36:2258-2269 (2004). RN [4]; RE0055138. RX PUBMED: 18611949. RA Ray S., Lee C., Hou T., Boldogh I., Brasier A. R. RT Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution. RL Nucleic Acids Res. 36:4510-4520 (2008). RN [5]; RE0055306. RX PUBMED: 17295906. RA Matthews J. R., Watson S. M., Tevendale M. C., Watson C. J., Clarke A. R. RT Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines. RL BMC Cancer 7:29 (2007). RN [6]; RE0067497. RX PUBMED: 15530426. RA Zhao H., Nakajima R., Kunimoto H., Sasaki T., Kojima H., Nakajima K. RT Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation. RL Biochem. Biophys. Res. Commun. 325:541-548 (2004). XX //