AC T08580
XX
ID T08580
XX
DT 20.02.2006 (created); kau.
DT 17.07.2014 (updated); pos.
CO Copyright (C), QIAGEN.
XX
FA STAT3-isoform1
XX
SY acute-phase response factor; APRF; signal transducer and activator of transcription 3.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004610 STAT3; HGNC: STAT3.
XX
CL C0039; STAT; 6.2.1.0.3.1.
XX
SZ 770 AA; 88.0 kDa (cDNA) (calc.).
XX
SQ MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
SQ LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
SQ TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQ SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
SQ ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELHQKVSYKGDPIVQ
SQ HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
SQ QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
SQ GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLSVVVISNICQMPNAWASILWY
SQ NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
SQ GCQITWANFCKENMAGKGFSYWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
SQ KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
SQ DATNILLSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
SQ TIDLPMSPRALDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
XX
SC translated from EMBL:L29277
XX
FT 2 122 
PF02865; STAT protein, protein interaction domain.
FT 138 319 
PF01017; STAT protein, all-alpha domain.
FT 170 456 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 321 574 
PF02864; STAT protein, DNA binding domain.
FT 580 670 
PS50001; SH2.
FT 584 674 
PF00017; SH2 domain.
XX
IN T04106 HDAC1; human, Homo sapiens.
IN T08256 SRC-1A; human, Homo sapiens.
XX
MX M00225 V$STAT3_01.
MX M00497 V$STAT3_02.
MX M07065 V$STAT3_Q4.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
XX
BS R22428.
BS R22348.
BS R22522.
BS R22475.
BS R14446.
BS R14447.
XX
DR TRANSPATH: MO000078237.
DR EMBL: L29277;
DR UniProtKB: P40763-1;
XX
RN [1]; RE0029151.
RX PUBMED: 11773079.
RA Giraud S., Bienvenu F., Avril S., Gascan H., Heery D. M., Coqueret O.
RT Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
RL J. Biol. Chem. 277:8004-11 (2002).
RN [2]; RE0053305.
RX PUBMED: 17909010.
RA Lo H. W., Hsu S. C., Xia W., Cao X., Shih J. Y., Wei Y., Abbruzzese J. L., Hortobagyi G. N., Hung M. C.
RT Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
RL Cancer Res. 67:9066-9076 (2007).
RN [3]; RE0053916.
RX PUBMED: 15313471.
RA Palmer J., Hertzog P. J., Hammacher A.
RT Differential expression and effects of gp130 cytokines and receptors in prostate cancer cells.
RL Int. J. Biochem. Cell Biol. 36:2258-2269 (2004).
RN [4]; RE0055138.
RX PUBMED: 18611949.
RA Ray S., Lee C., Hou T., Boldogh I., Brasier A. R.
RT Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution.
RL Nucleic Acids Res. 36:4510-4520 (2008).
RN [5]; RE0055306.
RX PUBMED: 17295906.
RA Matthews J. R., Watson S. M., Tevendale M. C., Watson C. J., Clarke A. R.
RT Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines.
RL BMC Cancer 7:29 (2007).
RN [6]; RE0067497.
RX PUBMED: 15530426.
RA Zhao H., Nakajima R., Kunimoto H., Sasaki T., Kojima H., Nakajima K.
RT Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation.
RL Biochem. Biophys. Res. Commun. 325:541-548 (2004).
XX
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