AC T04936
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ID T04936
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DT 27.11.2001 (created); rge.
DT 19.08.2014 (updated); hna.
CO Copyright (C), QIAGEN.
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FA MECP-2
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SY ARBP/MeCP2; MECP2; methyl-CpG-binding protein 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005550 MECP2; HGNC: MECP2.
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HO chicken ARBP [1].
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SF contains AT-hook motif [12];
SF mutations in the MECP2 gene cause Rett syndrome [9];
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CP highly expressed in central nervous system; ubiquitous, particular high levels in neuron of the postnatal brain [9].
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FF repressor;
FF concluded to bind to lysozyme 5' MAR and thereby repressing the downstream promoter in reporter gene constructs [2];
FF can act in a histone deacetylase-dependent and in a histone deacetylase-independent mode [11];
FF mutations cause Rett syndrome (RTT, neurological disorder);
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IN T04106 HDAC1; human, Homo sapiens.
IN T04109 hdac2-isoform1; human, Homo sapiens.
IN T14622 sin3a; human, Homo sapiens.
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MX M01298 V$MECP2_01.
MX M01299 V$MECP2_02.
MX M07049 V$MECP2_Q4.
MX M07388 V$MECP2_Q4_01.
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BS R62489.
BS R62344.
BS R63407.
BS R62997.
BS R39709.
BS R39710.
BS R39711.
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DR TRANSPATH: MO000028711.
DR SMARTDB: SB000102.
DR UniProtKB: P51608;
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RN [1]; RE0015861.
RX PUBMED: 9271441.
RA Weitzel J. M., Buhrmester H., Straetling W. H.
RT Chicken MAR-binding protein ARBP is homologous to rat methyl-CpG-binding protein MeCP2
RL Mol. Cell. Biol. 17:5656-5666 (1997).
RN [2]; RE0016296.
RX PUBMED: 10651247.
RA Straetling W. H., Yu F.
RT Origin and roles of nuclear matrix proteins. Specific functions of the MAR-binding protein MeCP2/ARBP
RL Crit. Rev. Eukaryot. Gene Expr. 9:311-318 (1999).
RN [3]; RE0017284.
RX PUBMED: 8976388.
RA Vilain A., Apiou F., Vogt N., Dutrillaux B., Malfoy B.
RT Assignment of the gene for methyl-CpG-binding protein 2 (MECP2) to human chromosome band Xq28 by in situ hybridization
RL Cytogenet. Cell Genet. 74:293-294 (1996).
RN [4]; RE0017285.
RX PUBMED: 8672133.
RA D'Esposito M., Quaderi N. A., Ciccodicola A., Bruni P., Esposito T., D'Urso M., Brown S. D.
RT Isolation, physical mapping, and northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2
RL Mamm. Genome 7:533-535 (1996).
RN [5]; RE0017286.
RX PUBMED: 10508514.
RA Amir R. E., Van den Veyver I. B., Wan M., Tran C. Q., Francke U., Zoghbi H. Y.
RT Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
RL Nat. Genet. 23:185-188 (1999).
RN [6]; RE0017287.
RX PUBMED: 11007980.
RA Orrico A., Lam C., Galli L., Dotti M. T., Hayek G., Tong S. F., Poon P. M., Zappella M., Federico A., Sorrentino V.
RT MECP2 mutation in male patients with non-specific X-linked mental retardation
RL FEBS Lett. 481:285-288 (2000).
RN [7]; RE0017288.
RX PUBMED: 10991688.
RA Obata K., Matsuishi T., Yamashita Y., Fukuda T., Kuwajima K., Horiuchi I., Nagamitsu S., Iwanaga R., Kimura A., Omori I., Endo S., Mori K., Kondo I.
RT Mutation analysis of the methyl-CpG binding protein 2 gene (MECP2) in patients with Rett syndrome
RL J. Med. Genet. 37:608-610 (2000).
RN [8]; RE0017289.
RX PUBMED: 10991689.
RA Hampson K., Woods C. G., Latif F., Webb T.
RT Mutations in the MECP2 gene in a cohort of girls with Rett syndrome
RL J. Med. Genet. 37:610-612 (2000).
RN [9]; RE0024624.
RX PUBMED: 12869202.
RA Heitmann B., Maurer T., Weitzel J. M., Straetling W. H., Kalbitzer H. R., Brunner E.
RT Solution structure of the matrix attachment region-binding domain of chicken MeCP2
RL Eur. J. Biochem. 270:3263-3270 (2003).
RN [10]; RE0024625.
RX PUBMED: 9620804.
RA Nan X., Ng H.-H., Johnson C. A., Laherty C. D., Turner B. M., Eisenman R. N., Bird A.
RT Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
RL Nature 393:386-389 (1998).
RN [11]; RE0024627.
RX PUBMED: 10773092.
RA Yu F., Thiesen J., Sraetling W. H.
RT Histone deacetylase independent transcriptional repression by metyl-CpG-binding protein 2
RL Nucleic Acids Res. 28:2201-2206 (2000).
RN [12]; RE0015873.
RX PUBMED: 9742243.
RA Aravind L., Landsman D.
RT AT-hook motifs identified in a wide variety of DNA-binding proteins
RL Nucleic Acids Res. 26:4413-4421 (1998).
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