AC T04077
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ID T04077
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DT 08.12.2000 (created); rio.
DT 12.05.2014 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA TGIF
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SY 5'-TG-3' interacting factor; 5'TG3' interacting factor; TG-interacting factor.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002126 Tgif1.
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CL C0006; homeo; 3.1.4.6.1.
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SF TALE (three amino acid loop extension) homeo domain superclass [1] [2];
SF 89% amino acid identity to human TGIF T04076 [2];
SF specifically expressed in the developing cerebellum and hippocampus [2];
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CP (embryo 12 days:) 1. branchial arch, lung bud, duodenum, hindlimb buds, brain, (embryo 15 days:) hippocampal formation, mesenceph. vesicle, cerebellar plate, vertebra, kidney, intestine, thymus, upper molars, tongue, (adult:) prolif. cells [2].
CN (adult:) superficial zone of squamous cells, papillae, lamina propria [2].
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FF probably regulates target genes involved in the proliferation, migration and/or differentiation of particular neuronal cell lineages in the developing brain [2];
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IN T06379 PML; mouse, Mus musculus.
IN T14622 sin3a; human, Homo sapiens.
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MX M00418 V$TGIF_01.
MX M01346 V$TGIF_02.
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DR TRANSPATH: MO000013622.
DR UniProtKB: P70284;
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RN [1]; RE0014544.
RX PUBMED: 9336443.
RA Burglin T. R.
RT Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals
RL Nucleic Acids Res. 25:4173-4180 (1997).
RN [2]; RE0015475.
RX PUBMED: 8901052.
RA Bertolino E., Wildt S., Richards G., Clerc R. G.
RT Expression of a novel murine homeobox gene in the developing cerebellar external granular layer during its proliferation
RL Dev. Dyn. 205:410-420 (1996).
RN [3]; RE0029026.
RX PUBMED: 11682623.
RA Sharma M., Sun Z.
RT 5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription.
RL Mol. Endocrinol. 15:1918-28 (2001).
RN [4]; RE0041634.
RX PUBMED: 11571228.
RA Wotton D., Knoepfler P. S., Laherty C. D., Eisenman R. N., Massague J.
RT The Smad transcriptional corepressor TGIF recruits mSin3
RL Cell Growth Differ. 12:457-63 (2001).
RN [5]; RE0049512.
RX PUBMED: 16428452.
RA Bartholin L., Powers S. E., Melhuish T. A., Lasse S., Weinstein M., Wotton D.
RT TGIF inhibits retinoid signaling.
RL Mol. Cell. Biol. 26:990-1001 (2006).
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