AC T01088
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ID T01088
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DT 24.02.1994 (created); ewi.
DT 05.02.2015 (updated); spk.
CO Copyright (C), QIAGEN.
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FA FOXK2a
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SY FOXK1a; ILF; ILF-1; ILF-1a; interleukin enhancer binding factor 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013784 FOXK2; HGNC: FOXK2.
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CL C0023; fork head; 3.3.1.11.2.1.
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SZ 660 AA; 69.1 kDa (cDNA) (calc.).
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SQ MAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNS
SQ SQGSVDVSMGHSSFISRRHLEIFTPPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG
SQ VFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTALSSEKREKQEASESPVKAVQPHIS
SQ PLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNSQ
SQ PENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADK
SQ GWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLIEQAFRKRRPRGVPCFRT
SQ PLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEAR
SQ FAQSAPGSPLSSQPVLITVQRQLPQAIKPVTYTVATPVTTSTSQPPVVQTVHVVHQIPAV
SQ SVTSVAGLAPANTYTVSGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPAIGHATLG
SQ TASRIIQTAQTTPVQTVTIVQQAPLGQHQLPIKTVTQNGTHVASVPTAVHGQVNNAAASP
SQ LHMLATHASASASLPTKRHNGDQPEQPELKRIKTEDGEGIVIALSVDTPPAAVREKGVQN
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SC Swiss-Prot#Q01167-1
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FT 225 637 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 251 342 
SM00339; forkneu4.
FT 253 348 
PF00250; Fork head domain.
FT 253 348 
PS50039; FORK_HEAD_3.
FT 257 348 
fork head domain [2].
FT 258 258 
essential for DNA binding [4].
FT 263 273 
helix alpha 1 [4].
FT 278 280 
strand beta S1 [4].
FT 281 290 
helix alpha 2 [4].
FT 299 312 
helix alpha 3 [4].
FT 300 300 essential for DNA binding [4].
FT 307 307 essential for DNA binding [4].
FT 316 321 strand beta s2 [4].
FT 328 328 essential for DNA binding [4].
FT 331 332 strand beta s3 [4].
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SF Molecular model of FOXK2a has been constructed [4];
SF fork head domain essential for DNA-binding [1];
SF ILF1, the paralog of FOXK1, was designated FOXK2 [3];
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CP (cell lines:) HeLa [1].
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IN T14622 sin3a; human, Homo sapiens.
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BS R19483.
BS R03641.
BS R03642.
BS R00930.
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DR TRANSPATH: MO000045453.
DR EMBL: U58196;
DR UniProtKB: Q01167-1;
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RN [1]; RE0002542.
RX PUBMED: 1909027.
RA Li C., Lai C., Sigman D. S., Gaynor R. B.
RT Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat
RL Proc. Natl. Acad. Sci. USA 88:7739-7743 (1991).
RN [2]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [3]; RE0025396.
RX PUBMED: 15202027.
RA Katoh M., Katoh M.
RT Identification and characterization of human FOXK1 gene in silico.
RL Int. J. Mol. Med. 14:127-132 (2004).
RN [4]; RE0047944.
RX PUBMED: 16624804.
RA Tsai K. L., Huang C. Y., Chang C. H., Sun Y. J., Chuang W. J., Hsiao C. D.
RT Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins.
RL J. Biol. Chem. 281:17400-17409 (2006).
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