AC T02322
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ID T02322
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DT 15.12.1997 (created); ili.
DT 02.01.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA BCL-6
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SY B cell lymphoma 6 protein; BCL-5; BCL-6; LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51; ZNF51.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004696 BCL6; HGNC: BCL6.
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CL C0001; CH; 2.3.3.22.2.
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SF phosphoprotein [3];
SF repressing activity is mediated by the N-terminal part [3];
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CP mature B cells and skeletal muscle [1].
CN pro-B cells, T cells or other hematopoietic cell lineages [1].
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FF repressor [2];
FF specific binding shown for zinc finger domain as well as for full-length factor [2];
FF located on 3q27 [1];
FF BCL-6 rearrangements are specific for and frequent in diffuse large-cell lymphoma (DLCL) [1];
FF a significant fraction of follicular lymphoma also contain structural alterations of the regulatory region of the BCL-6 gene [3];
FF may play role in normal B cell differentiation and lymphoid organ development [1];
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IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T25625 hdac2; human, Homo sapiens.
IN T04797 PATZ; human, Homo sapiens.
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MX M01183 V$BCL6_01.
MX M01185 V$BCL6_02.
MX M01171 V$BCL6_Q3.
MX M02085 V$BCL6_Q3_01.
MX M07375 V$BCL6_Q6.
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BS R36483.
BS R36580.
BS R36584.
BS R26236.
BS R73222.
BS R60553.
BS R30894.
BS R63132.
BS R61481.
BS R16701.
BS R16702.
BS R30895.
BS R29408.
BS R17199.
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DR TRANSPATH: MO000026319.
DR UniProtKB: P41182;
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RN [1]; RE0006494.
RX PUBMED: 8235596.
RA Ye B. H., Lista F., Lo Coco F., Knowles D. M., Offit K., Chaganti R. S. K., Dalla-Favera R.
RT Alterations of a zinc finger-encoding gene BCL-6, in diffuse large-cell lymphoma
RL Science 262:747-750 (1993).
RN [2]; RE0006495.
RX PUBMED: 9135990.
RA Baron B. W., Desai M., Baber L. J., Paras L., Zhang Q., Sadhu A., Duguay S., Nucifora G., McKeithan T. W., Zeleznik-Le N.
RT BCL6 can repress transsription from the human immunodeficiency virus typeI promoter/enhancer region
RL Genes Chromosomes Cancer 19:14-21 (1997).
RN [3]; RE0006496.
RX PUBMED: 8692924.
RA Chang C.-C., Ye B. H., Chaganti R. S. K., Dalla-Favera R.
RT BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor
RL Proc. Natl. Acad. Sci. USA 93:6947-6952 (1996).
RN [4]; RE0048105.
RX PUBMED: 12402037.
RA Bereshchenko O. R., Gu W., Dalla-Favera R.
RT Acetylation inactivates the transcriptional repressor BCL6.
RL Nat. Genet. 32:606-613 (2002).
RN [5]; RE0052481.
RX PUBMED: 12590135.
RA Petrie K., Guidez F., Howell L., Healy L., Waxman S., Greaves M., Zelent A.
RT The histone deacetylase 9 gene encodes multiple protein isoforms.
RL J. Biol. Chem. 278:16059-16072 (2003).
RN [6]; RE0053562.
RX PUBMED: 16704730.
RA Liu H., Ippolito G. C., Wall J. K., Niu T., Probst L., Lee B. S., Pulford K., Banham A. H., Stockwin L., Shaffer A. L., Staudt L. M., Das C., Dyer M. J., Tucker P. W.
RT Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.
RL Mol. Cancer 5:18 (2006).
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