AC T01713
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ID T01713
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DT 07.03.1996 (created); ewi.
DT 01.12.2009 (updated); jul.
CO Copyright (C), QIAGEN.
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FA HOXA10-PL1
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SY HOX1H; PL1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013852 HOXA10; HGNC: HOXA10.
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HO Abd-B (Drosophila).
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CL C0006; homeo; 3.1.1.8.5.1.
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SZ 393 AA; 40.5 kDa (cDNA) (calc.).
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SQ MSCSESPAANSFLVDSLISSGRGEAGGGGGGAGGGGGGGYYAHGGVYLPPAADLPYGLQS
SQ CGLFPTLGGKRNEAASPGSGGGGGGLGPGAHGYGPSPIDLWLDAPRSCRMEPPDGPPPPP
SQ QQQPPPPPQPPQPAPQATSCSFAQNIKEESSYCLYDSADKCPKVSATAAELAPFPRGPPP
SQ DGCALGTSSGVPVPGYFRLSQAYGTAKGYGSGGGGAQQLGAGPFPAQPPGRGFDLPPALA
SQ SGSADAARKERALDSPPPPTLACGSGGGSQGDEEAHASSSAAEELSPAPSESSKASPEKD
SQ SLGNSKGENAANWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTD
SQ RQVKIWFQNRRMKLKKMNRENRIRELTANFNFS
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SC Swiss-Prot#P31260-1
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FT 124 146 
"PQ-like" activation domain [4].
FT 317 377 
PS50071; HOMEOBOX_2.
FT 319 381 
SM00389; HOX_1.
FT 320 376 
PF00046; Homeobox.
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CP myelomonocytic cells [2] [3]; low level throughout the proliferative phase, increasing by the middle and late secretory phases [6]; high expression in the endometrium of Uterus [6].
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IN T25625 hdac2; human, Homo sapiens.
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MX M01464 V$HOXA10_01.
MX M03873 V$HOXA10_Q5.
MX M07257 V$HOXA10_Q6.
MX M07456 V$HOXA913_Q4.
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BS R22992.
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DR TRANSPATH: MO000025889.
DR EMBL: M30599;
DR EMBL: X58430;
DR UniProtKB: P31260-1;
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RN [1]; RE0003895.
RX PUBMED: 2574852.
RA Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.
RT The human HOX gene family
RL Nucleic Acids Res. 17:10385-10402 (1989).
RN [2]; RE0003900.
RX PUBMED: 1676505.
RA Lowney P., Corral J., Detmer K., Lebeau M. M., Deaven L., Lawrence H. J., Largman C.
RT A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells
RL Nucleic Acids Res. 19:3443-3449 (1991).
RN [3]; RE0003901.
RX PUBMED: 2573064.
RA Shen W. F., Largman C., Lowney P., Corral J. C., Detmer K., Hauser C. A., Simonitch T. A., Hack F. M., Lawrence H. J.
RT Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines
RL Proc. Natl. Acad. Sci. USA 86:8536-8540 (1989).
RN [4]; RE0050661.
RX PUBMED: 17439948.
RA Bei L., Lu Y., Bellis S. L., Zhou W., Horvath E., Eklund E. A.
RT Identification of a HoxA10 activation domain necessary for transcription of the gene encoding beta3 integrin during myeloid differentiation.
RL J. Biol. Chem. 282:16846-16859 (2007).
RN [5]; RE0065030.
RX PUBMED: 14512427.
RA Lu Y., Goldenberg I., Bei L., Andrejic J., Eklund E. A.
RT HoxA10 represses gene transcription in undifferentiated myeloid cells by interaction with histone deacetylase 2.
RL J. Biol. Chem. 278:47792-47802 (2003).
RN [6]; RE0029848.
RX PUBMED: 12482956.
RA Troy P. J., Daftary G. S., Bagot C. N., Taylor H. S.
RT Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10.
RL Mol. Cell. Biol. 23:1-13 (2003).
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