AC T00929
AS T23608.
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ID T00929
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DT 15.06.1993 (created); ewi.
DT 29.04.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA Blimp-1
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SY Beta-interferon gene positive regulatory domain I-binding factor; Blimp-1; BLIMP1; Positive regulatory domain I-binding factor 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PRDI-BF1; PRDM1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G014469 PRDM1; HGNC: PRDM1.
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CL C0001; CH; 2.3.3.12.1.
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SF 5 zinc finger motifs;
SF basic, acidic region, serine-/threonine-rich region;
SF zinc finger 1 and 2 are sufficient for DNA-binding [2];
SF over all similarity to murine factor Blimp-1 T02316 [3];
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CP extrafollicular area of the tonsils where plasma cells are found, in a subset of germinal center B cells, and in squamous epithelium [5].
EX tonsil,B-lymphocyte,,adult; detectable; Northern blot; RNA (undefined); [5].
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FF Blimp1-dependent repression of Pax5 is necessary for plasmacytic differentiation [5];
FF transcriptional repressor [4];
FF repressor of the IFN-beta gene, virus-inducible;
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IN T25625 hdac2; human, Homo sapiens.
IN T34270 LSD1; human, Homo sapiens.
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MX M05486 V$BLIMP1_02.
MX M07314 V$BLIMP1_Q4.
MX M01066 V$BLIMP1_Q6.
MX M03865 V$BLIMP1_Q6_01.
MX M03916 V$PRDM1_02.
MX M04731 V$PRDM1_03.
MX M07121 V$PRDM1_05.
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BS R03274.
BS R17169.
BS R17184.
BS R17189.
BS R17174.
BS R58176.
BS R71097.
BS R71098.
BS R71087.
BS R71088.
BS R71089.
BS R71090.
BS R71091.
BS R71092.
BS R71093.
BS R71094.
BS R71095.
BS R71096.
BS R71105.
BS R71106.
BS R71107.
BS R71108.
BS R67430.
BS R71109.
BS R71110.
BS R71099.
BS R71100.
BS R71101.
BS R71102.
BS R71103.
BS R71104.
BS R36496.
BS R17185.
BS R17171.
BS R17175.
BS R17176.
BS R17182.
BS R17173.
BS R02235.
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DR TRANSPATH: MO000025278.
DR UniProtKB: O75626;
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RN [1]; RE0000687.
RX PUBMED: 1851123.
RA Keller A. D., Maniatis T.
RT Identification and characterization of a novel repressor of beta-interferon gene expression
RL Genes Dev. 5:868-879 (1991).
RN [2]; RE0003061.
RX PUBMED: 1569931.
RA Keller A. D., Maniatis T.
RT Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding
RL Mol. Cell. Biol. 12:1940-1949 (1992).
RN [3]; RE0006485.
RX PUBMED: 8033216.
RA Huang S.
RT Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1
RL Cell 78:9 (1994).
RN [4]; RE0035349.
RX PUBMED: 12150891.
RA Shaffer A. L., Lin K. I., Kuo T. C., Yu X., Hurt E. M., Rosenwald A., Giltnane J. M., Yang L., Zhao H., Calame K., Staudt L. M.
RT Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program.
RL Immunity 17:51-62 (2002).
RN [5]; RE0035360.
RX PUBMED: 12052884.
RA Lin K. I., Angelin-Duclos C., Kuo T. C., Calame K.
RT Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells.
RL Mol. Cell. Biol. 22:4771-4780 (2002).
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