AC T02397
XX
ID T02397
XX
DT 08.04.1998 (created); ewi.
DT 01.09.2006 (updated); rad.
CO Copyright (C), QIAGEN.
XX
FA Sin3A-xbb2
XX
SY mSin3A; Sin3; Sin3a; transcriptional regulator, SIN3A (yeast).
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G014387 Sin3a.
XX
SZ 1219 AA; 138.7 kDa (cDNA) (calc.).
XX
SQ MKRRLDDQESPVYAAQQRRIPGSTEAFSHQHRVLAPAPPVYEAVSETMQSATGIQYSVAP
SQ NYQVSAVPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR
SQ LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
SQ GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSSQSAPTPAQ
SQ PAPQPTAAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
SQ PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
SQ QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
SQ SQNGCQIRRHSGTGATPPVKKKPKLMSLKESSMADASKHGVGTESLFFDKVRKALRSAEA
SQ YENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLESFPKERAT
SQ EGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVS
SQ SKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGG
SQ TSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWRE
SQ QNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSL
SQ AYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEE
SQ EEMDVDEATGAPKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLH
SQ QILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYY
SQ PAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEVCVQ
SQ VTDLYLAENNNGATGGQLNSQTSRSLLESAYQRKAEQLMSDENCFKLMFIQSQGQVQLTV
SQ ELLDTEEENSDDPVEAERWSDYVERYMSSDTTSPELREHLAQKPVFLPRNLRRIRKCQRG
SQ REQQEKEGKEGNSKKTMENVESLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSH
SQ ERVSQGKSRGIHNFFLQIL
XX
SC translated from EMBL:I61713
XX
FT 25 559 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 141 187 
PF02671; Paired amphipathic helix repeat.
FT 322 381 
PF02671; Paired amphipathic helix repeat.
FT 478 524 
PF02671; Paired amphipathic helix repeat.
XX
SF Sin3A (1) T02395 and Sin3A (2) T02396 may be alternative splice products;
XX
FF co-repressor;
XX
IN T14621 Ebp1; human, Homo sapiens.
IN T14623 Ebp1; Mammalia.
IN T25625 hdac2; human, Homo sapiens.
IN T09020 Mad4; mouse, Mus musculus.
XX
DR TRANSPATH: MO000026387.
DR EMBL: I61713;
XX
RN [1]; RE0006786.
RX PUBMED: 8521822.
RA Hurlin P. J., Queva C., Koskinen P. J., Steingrimsson E., Ayer D. E., Copeland N. G., Jenkins N. A., Eisenman R. N.
RT Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
RL EMBO J. 14:5646-5659 (1995).
RN [2]; RE0006789.
RX PUBMED: 7889570.
RA Ayer D. E., Lawrence Q. A., Eisenman R. N.
RT Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
RL Cell 80:767-776 (1995).
RN [3]; RE0045656.
RX PUBMED: 12391155.
RA Yochum G. S., Ayer D. E.
RT Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split
RL Mol. Cell. Biol. 22:7868-76 (2002).
RN [4]; RE0048159.
RX PUBMED: 16254079.
RA Zhang Y., Akinmade D., Hamburger A. W.
RT The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription.
RL Nucleic Acids Res. 33:6024-6033 (2005).
XX
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