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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T02397 XX ID T02397 XX DT 08.04.1998 (created); ewi. DT 01.09.2006 (updated); rad. CO Copyright (C), QIAGEN. XX FA Sin3A-xbb2 XX SY mSin3A; Sin3; Sin3a; transcriptional regulator, SIN3A (yeast). XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G014387 Sin3a. XX SZ 1219 AA; 138.7 kDa (cDNA) (calc.). XX SQ MKRRLDDQESPVYAAQQRRIPGSTEAFSHQHRVLAPAPPVYEAVSETMQSATGIQYSVAP SQ NYQVSAVPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR SQ LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM SQ GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSSQSAPTPAQ SQ PAPQPTAAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ SQ PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA SQ QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP SQ SQNGCQIRRHSGTGATPPVKKKPKLMSLKESSMADASKHGVGTESLFFDKVRKALRSAEA SQ YENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLESFPKERAT SQ EGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVS SQ SKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGG SQ TSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWRE SQ QNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSL SQ AYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEE SQ EEMDVDEATGAPKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLH SQ QILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYY SQ PAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEVCVQ SQ VTDLYLAENNNGATGGQLNSQTSRSLLESAYQRKAEQLMSDENCFKLMFIQSQGQVQLTV SQ ELLDTEEENSDDPVEAERWSDYVERYMSSDTTSPELREHLAQKPVFLPRNLRRIRKCQRG SQ REQQEKEGKEGNSKKTMENVESLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSH SQ ERVSQGKSRGIHNFFLQIL XX SC translated from EMBL:I61713 XX FT 25 559 PF00478; IMP dehydrogenase / GMP reductase domain. FT 141 187 PF02671; Paired amphipathic helix repeat. FT 322 381 PF02671; Paired amphipathic helix repeat. FT 478 524 PF02671; Paired amphipathic helix repeat. XX SF Sin3A (1) T02395 and Sin3A (2) T02396 may be alternative splice products; XX FF co-repressor; XX IN T14621 Ebp1; human, Homo sapiens. IN T14623 Ebp1; Mammalia. IN T25625 hdac2; human, Homo sapiens. IN T09020 Mad4; mouse, Mus musculus. XX DR TRANSPATH: MO000026387. DR EMBL: I61713; XX RN [1]; RE0006786. RX PUBMED: 8521822. RA Hurlin P. J., Queva C., Koskinen P. J., Steingrimsson E., Ayer D. E., Copeland N. G., Jenkins N. A., Eisenman R. N. RT Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation RL EMBO J. 14:5646-5659 (1995). RN [2]; RE0006789. RX PUBMED: 7889570. RA Ayer D. E., Lawrence Q. A., Eisenman R. N. RT Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 RL Cell 80:767-776 (1995). RN [3]; RE0045656. RX PUBMED: 12391155. RA Yochum G. S., Ayer D. E. RT Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split RL Mol. Cell. Biol. 22:7868-76 (2002). RN [4]; RE0048159. RX PUBMED: 16254079. RA Zhang Y., Akinmade D., Hamburger A. W. RT The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription. RL Nucleic Acids Res. 33:6024-6033 (2005). XX //