AC T02395
XX
ID T02395
XX
DT 08.04.1998 (created); ewi.
DT 13.03.2008 (updated); pum.
CO Copyright (C), QIAGEN.
XX
FA Sin3A-2
XX
SY Histone deacetylase complex subunit Sin3a; mSin3A; paired amphipathic helix protein Sin3a; Sin3; Sin3a; Transcriptional corepressor Sin3a.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G014387 Sin3a.
XX
SZ 1274 AA; 145.1 kDa (cDNA) (calc.).
XX
SQ MKRRLDDQESPVYAAQQRRIPGSTEAFSHQHRVLAPAPPVYEAVSETMQSATGIQYSVAP
SQ NYQVSAVPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQR
SQ LKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIM
SQ GFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSSQSAPTPAQ
SQ PAPQPTAAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQ
SQ PVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYA
SQ QVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRP
SQ SQNGCQIRRHSGTGATPPVKKKPKLMSLKESSMADASKHGVGTESLFFDKVRKALRSAEA
SQ YENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLESFPKERAT
SQ EGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVS
SQ SKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGG
SQ TSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWRE
SQ QNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSL
SQ AYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFDQRGDLSDVEEEEE
SQ EEMDVDEATGAPKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLH
SQ QILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYY
SQ PAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEVCVQ
SQ VTDLYLAENNNGATGGQLNSQTSRSLLESAYQRKAEQLMSDENCFKLMFIQSQGQVQLTV
SQ ELLDTEEENSDDPVEAERWSDYVERYMSSDTTSPELREHLAQKPVFLPRNLRRIRKCQRG
SQ REQQEKEGKEGNSKKTMENVESLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSH
SQ ERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSI
SQ NKYRVKYGTVFKAP
XX
SC Swiss-Prot#Q60520-2
XX
FT 25 559 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 141 187 
PF02671; Paired amphipathic helix repeat.
FT 322 381 
PF02671; Paired amphipathic helix repeat.
FT 478 524 
PF02671; Paired amphipathic helix repeat.
XX
SF Sin3A (2) T02396 and Sin3A (3) T02397 may be alternative splice products;
XX
FF co-repressor;
XX
IN T02391 Mad3; mouse, Mus musculus.
IN T02392 Mad4; mouse, Mus musculus.
XX
DR TRANSPATH: MO000026385.
DR EMBL: U22394;
DR UniProtKB: Q60520-2;
XX
RN [1]; RE0006788.
RX PUBMED: 8649810.
RA Rao G., Alland L., Guida P., Schreiber-Agus N., Chen K., Chin L., Rochelle J. M., Seldin M. F., Skoultchi A. I., DePinho R. A.
RT Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1
RL Oncogene 12:1165-1172 (1996).
RN [2]; RE0038190.
RX PUBMED: 11909966.
RA Alland L., David G., Shen-Li H., Potes J., Muhle R., Lee H. C., Hou H. Jr, Chen K., DePinho R. A.
RT Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex
RL Mol. Cell. Biol. 22:2743-50 (2002).
XX
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