AC T09020
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ID T09020
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DT 07.06.2006 (created); jag.
DT 09.08.2007 (updated); res.
CO Copyright (C), QIAGEN.
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FA Mad4
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SY MAD4; MAX dimerization protein 4.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006378 Mxd4.
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CL C0012; bHLH-ZIP.
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SZ 209 AA; 23.6 kDa (cDNA) (calc.).
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SQ MELNSLLLLLEAAEYLERRDREAEHGYASMLPFDGDFARKKTKTAGLVRKGPNNRSSHNE
SQ LEKHRRAKLRLYLEQLKQLGPLGPDSTRHTTLSLLKRAKMHIKKLEEQDRRALSIKEQLQ
SQ REHRFLKRRLEQLSVQSVERVRTDSTGSAVSTDDSEQEVDIEGMEFGPGELDSAGSSSDA
SQ DDHYSLQSSGCSDSSYGHPCRRPGCPGLS
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SC SPTREMBL #Q60948
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FT 6 23 
Sin3-interacting domain (SID) [1].
FT 38 106 
PS50888; HLH.
FT 54 106 
PF00010; Helix-loop-helix DNA-binding domain.
FT 55 66 
basic region [1].
FT 59 111 
SM00353; finulus.
FT 67 104 
helix-loop-helix domain [1].
FT 105 133 
leucine zipper (LAL3) [1].
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FF expression represses transcription especially in combination with Max [1];
FF antagonize transcriptional activities of c-Myc [1];
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IN T05056 Max; human, Homo sapiens.
IN T09085 Max; Mammalia.
IN T02397 Sin3A-xbb2; mouse, Mus musculus.
IN T09021 Sin3B-isoform1; mouse, Mus musculus.
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DR TRANSPATH: MO000082623.
DR EMBL: U32395;
DR UniProtKB: Q60948;
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RN [1]; RE0006786.
RX PUBMED: 8521822.
RA Hurlin P. J., Queva C., Koskinen P. J., Steingrimsson E., Ayer D. E., Copeland N. G., Jenkins N. A., Eisenman R. N.
RT Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
RL EMBO J. 14:5646-5659 (1995).
RN [2]; RE0050488.
RX PUBMED: 15121849.
RA Grinberg A. V., Hu C. D., Kerppola T. K.
RT Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells.
RL Mol. Cell. Biol. 24:4294-4308 (2004).
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