AC T09272
XX
ID T09272
XX
DT 29.08.2006 (created); rad.
DT 04.12.2006 (updated); sou.
CO Copyright (C), QIAGEN.
XX
FA SMRT-Alpha
XX
SY N-COR2; nuclear receptor co-repressor 2; silencing mediator of retinoic acid and thyroid hormone; SMRT; SMRTE; T3 receptor-associating factor; TRAC.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002794 Ncor2.
XX
CL C0022; trp.
XX
SZ 2473 AA; 271.1 kDa (cDNA) (calc.).
XX
SQ MSGSTQPVAQTWRAAEPRYPPHGISYPVQIARSHTDVGLLEYQHHPRDYTSHLSPGSIIQ
SQ PQRRRPSLLSEFQPGSERSQELHLRPESRTFLPELGKPDIEFTESKRPRLELLPDTLLRP
SQ SPLLATGQPSGSEDLTKDRSLAGKLEPVSPPSPPHADPELELAPSRLSKEELIQNMDRVD
SQ REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA
SQ AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQRFCQ
SQ RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG
SQ LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMDDPM
SQ KVYKDRQVTNMWSEQERDTFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK
SQ SLVRRSYRRRGKSQQQQQQQQQQQQQQMARSSQEEKEEKEKEKEADKEEEKQDAENEKEE
SQ LSKEKTDDTSGEDNHEKEAVASKGRKTANSQGRRKGRITRSMANEANHEETATPQQSSEL
SQ ASMEMNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDE
SQ ILQQHKLKMEKERNARRKKKKTPAAASEETAFPPAAEDEEMEASGASANEEELAEEAEAS
SQ QASGNEVPRVGECSGPAAVNNSSDTESVPSPRSEAMKDTGPKPTGTEALPAATQPPVPPP
SQ EEPAVAPAEPSPVPDASGPPSPEPSHHLPHPRLLWTRMNKKPRLLQLPRQRMPRSRSLRP
SQ RRSMWEKPEEPEASEEPPESVKSDHKEETEEEPEDKAKGTEAIETVSEAPLKVEEAGSKA
SQ AVTKGSSSGATQDSDFSATCSADEVDEPEGGDKGRLLSPRPSLLTPAGDPRASTSPQKPL
SQ DLKQLKQRAAAIPPIQVTKVHEPPREDTVPPKPVPPVPPPTQHLQPEGDVSQQSGGSPRG
SQ KSRSPVPPAEKEAEKPAFFPAFPTEGPKLPTEPPRWSSGLPFPIPPREVIKTSPHAADPS
SQ AFSYTPPGHPLPLGLHDSARPVLPRPPISNPPPLISSAKHPGVLERQLGAISQQGMSVQL
SQ RVPHSEHAKAPMGPLTMGLPLAVDPKKLGTALGSATSGSITKGLPSTRAADGPSYRGSIT
SQ HGTPADVLYKGTISRIVGEDSPSRLDRAREDTLPKGHVIYEGKKGHVLSYEGGMSVSQCS
SQ KEDGRSSSGPPHETAAPKRTYDMMEGRVGRTVTSASIEGLMGRAIPEQHSPHLKEQHHIR
SQ GSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPPRDLTETYKPRPLDPLGPLKLKP
SQ THEGVVATVKEAGRSIHEIPREELRRTPELPLAPRPLKEGSITQGTPLKYDSGAPSTGTK
SQ KHDVRSIIGSPGRPFPALHPLDIMADARALERACYEESLKSRSGTSSGAGGSITRGAPVV
SQ VPELGKPRQSPLTYEDHGAPFTSHLPRGSPVTTREPTPRLQEGSLLSSKASQDRKLTSTP
SQ REIAKSPHSTVPEHHPHPISPYEHLLRGVTGVDLYRGHIPLAFDPTSIPRGIPLEAAAAA
SQ YYLPRHLAPSPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAASAMAQRAD
SQ MLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAIDRLAYLPTAPPPF
SQ SSRHSSSPLSPGGPTHLAKPTATSSSERERERERERDKSILTSTTTVEHAPIWRPGTEQS
SQ SGAGGSSRPASHTHQHSPISPRTQDALQQRPSVLHNTSMKGVVTSVEPGTPTVLRWARST
SQ STSSPVRPAATFPPATHCPLGGTLEGVYPTLMEPVLLPKETSRVARPERARVDAGHAFLT
SQ KPPGREPASSPSKSSEPRSLAPPSSSHTAIARTPAKNLAPHHASPDPPAPTSASDLHREK
SQ TQSKPFSIQELELRSLGYHSGAGYSPDGVEPISPVSSPSLTHDKGLSKPLEELEKSHLEG
SQ ELRHKQPGPMKLSAEAAHLPHLRPLPESQPSSSPLLQTAPGIKGHQRVVTLAQHISEVIT
SQ QDYTRHHPQQLSGPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGTPARGSPHSEGGK
SQ RSPEPSKTSVLGSSEDAIEPVSPPEGMTEPGHARSTAYPLLYRDGEQGEPRMGLESPGNT
SQ SQPPTFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNIGQPGTEIFNMPAITGAGLM
SQ TCRSQAVQEHASTNMGLEAIIRKALMGKYDQWEEPPPLGANAFNPLNASASLPAAAMPIT
SQ TADGRSDHALTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTP
SQ LTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLAAGSGPLAGPHHAWDEEPKP
SQ LLCSQYETLSDSE
XX
SC translated from EMBL #AF113001 (deviates from Swiss-Prot #Q9WU42 in some positions)
XX
FT 428 476 
SM00717; sant.
FT 429 474 
PF00249; Myb-like DNA-binding domain.
FT 607 655 
SM00717; sant.
FT 608 653 
PF00249; Myb-like DNA-binding domain.
FT 609 653 
PS50090; MYB_3.
XX
IN T09905 B-Myb; mouse, Mus musculus.
IN T04110 HDAC3; human, Homo sapiens.
XX
DR TRANSPATH: MO000085903.
DR EMBL: AF113001;
DR UniProtKB: Q9WU42-1;
XX
RN [1]; RE0005939.
RX PUBMED: 9150137.
RA Nagy L., Kao H.-Y., Chakravarti D., Lin R. J., Hassig C. A., Ayer D. E., Schreiber S. L., Evans R. M.
RT Nuclear receptor repression mediated by a complex containing SMRT, mSin3a, and histone deacetylase
RL Cell 89:373-380 (1997).
RN [2]; RE0016802.
RX PUBMED: 10617570.
RA Nagy L., Kao H. Y., Love J. D., Li C., Banayo E., Gooch J. T., Krishna V., Chatterjee K., Evans R. M., Schwabe J. W.
RT Mechanism of corepressor binding and release from nuclear hormone receptors
RL Genes Dev. 13:3209-3216 (1999).
RN [3]; RE0016920.
RX PUBMED: 9755173.
RA Muto A., Hoshino H., Madisen L., Yanai N., Obinata M., Karasuyama H., Hayashi N., Nakauchi H., Yamamoto M., Groudine M., Igarashi K.
RT Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer
RL EMBO J. 17:5734-5743 (1998).
RN [4]; RE0026518.
RX PUBMED: 10809664.
RA Guenther M. G., Lane W. S., Fischle W., Verdin E., Lazar M. A., Shiekhattar R.
RT A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
RL Genes Dev. 14:1048-57 (2000).
RN [5]; RE0038030.
RX PUBMED: 11509652.
RA Guenther M. G., Barak O., Lazar M. A.
RT The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
RL Mol. Cell. Biol. 21:6091-101 (2001).
RN [6]; RE0046322.
RX PUBMED: 11997503.
RA Li X., McDonnell D. P.
RT The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT
RL Mol. Cell. Biol. 22:3663-73 (2002).
RN [7]; RE0048154.
RX PUBMED: 10984530.
RA Downes M., Ordentlich P., Kao H. Y., Alvarez J. G., Evans R. M.
RT Identification of a nuclear domain with deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 97:10330-10335 (2000).
XX
//