AC T00143
XX
ID T00143
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DT 26.01.1993 (created); hse.
DT 09.03.2016 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA c-Myc
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SY c-Myc.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000489 Myc.
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CL C0012; bHLH-ZIP; 1.2.6.5.1.
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SF c-myc proto-oncogene;
SF nuclear protein;
SF glycoprotein;
SF efficient DNA binding requires dimerization with another bHLH protein;
SF binds DNA as an heterodimer with Max [12] [14];
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CP brain, testis, liver [15].
EX brain,,,Theiler Stage 27; high; RNAse protection assay; total RNA; [8].
EX brain,,,adult; none; RNAse protection assay; total RNA; [8].
EX intestine,,,Theiler Stage 27; medium; RNAse protection assay; total RNA; [8].
EX intestine,,,adult; medium; RNAse protection assay; total RNA; [8].
EX kidney (right and left),,,Theiler Stage 27; medium; RNAse protection assay; total RNA; [8].
EX kidney (right and left),,,adult; none; RNAse protection assay; total RNA; [8].
EX liver,,,Theiler Stage 27; medium; RNAse protection assay; total RNA; [8].
EX liver,,,adult; low; RNAse protection assay; total RNA; [8].
EX lung,,,Theiler Stage 27; medium; RNAse protection assay; total RNA; [8].
EX lung,,,adult; medium; RNAse protection assay; total RNA; [8].
XX
FF transcriptional regulator;
FF activator [12];
FF forced overexpression of c-Myc in lens fiber cells causes inappropriate cell cycle progression [9];
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IN T00143 c-Myc; mouse, Mus musculus.
IN T09997 Hsp90; mouse, Mus musculus.
IN T00489 Max-isoform2; human, Homo sapiens.
IN T00523 Max; mouse, Mus musculus.
IN T09085 Max; Mammalia.
IN T06377 PML; human, Homo sapiens.
XX
MX M01145 V$CMYC_01.
MX M01154 V$CMYC_02.
MX M07601 V$CMYC_Q3.
MX M03867 V$CMYC_Q6_01.
MX M01034 V$EBOX_Q6_01.
MX M00118 V$MYCMAX_01.
MX M00123 V$MYCMAX_02.
MX M00615 V$MYCMAX_03.
MX M00322 V$MYCMAX_B.
MX M02250 V$MYC_01.
MX M00799 V$MYC_Q2.
XX
BS R18513.
BS R18516.
BS R18517.
BS R73916.
BS R04455.
BS R62877.
BS R18512.
BS R70119.
BS R70128.
BS R70129.
BS R62849.
BS R70124.
BS R70125.
BS R70130.
BS R70122.
BS R34321.
BS R70121.
BS R70127.
BS R72345.
BS R72344.
BS R31070.
BS R70123.
BS R09544.
BS R70120.
BS R70126.
BS R70131.
BS R02207.
XX
DR TRANSPATH: MO000024730.
DR TRANSCOMPEL: C00119.
DR UniProtKB: P01108;
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RN [1]; RE0000173.
RX PUBMED: 1840505.
RA Prendergast G. C., Lawe D., Ziff E. B.
RT Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation
RL Cell 65:395-407 (1991).
RN [2]; RE0000428.
RX PUBMED: 2686984.
RA Ariga H., Imamura Y., Iguchi-Ariga S. M. M.
RT DNA replication origin and transcriptional enhancer in c-myc gene share the c-myc protein binding sequences
RL EMBO J. 8:4273-4279 (1989).
RN [3]; RE0001483.
RX PUBMED: 1990293.
RA Dang C. V., Barrett J., Villa-Garcia M., Resar L. M. S., Kato G. J., Fearon E. R.
RT Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization
RL Mol. Cell. Biol. 11:954-962 (1991).
RN [4]; RE0002652.
RX PUBMED: 2251503.
RA Blackwell T. K., Kretzner L., Blackwood E. M., Eisenman R. N., Weintraub H.
RT Sequence-specific DNA binding by the c-Myc protein
RL Science 250:1149-1151 (1990).
RN [5]; RE0002653.
RX PUBMED: 2006410.
RA Blackwood E. M., Eisenman R. N.
RT Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc
RL Science 251:1211-1217 (1991).
RN [6]; RE0003342.
RX PUBMED: 1549358.
RA Moberg K. H., Logan T. J., Tyndall W. A., Hall D. J.
RT Three distinct elements within the murine c-myc promoter are required for transcription
RL Oncogene 7:411-421 (1992).
RN [7]; RE0003349.
RX PUBMED: 3024965.
RA Nepveu A., Marcu K. B.
RT Intragenic pausing and anti-sense transcription within the murine c-myc locus
RL EMBO J. 5:2859-2865 (1986).
RN [8]; RE0005851.
RX PUBMED: 7667316.
RA Chin L., Schreiber-Agus N., Pellicer I., Chen K., Lee H.-W., Dudast M., Cordon-Cardo C., DePinho R. A.
RT Contrasting roles for Myc and Mad proteins in cellular growth and differentiation
RL Proc. Natl. Acad. Sci. USA 92:8488-8492 (1995).
RN [9]; RE0006781.
RX PUBMED: 7882978.
RA Morgenbesser S. D., Schreiber-Agus N., Bidder M., Mahon K. A., Overbeek P. A., Horner J., DePinho R. A.
RT Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo
RL EMBO J. 14:743-756 (1995).
RN [10]; RE0006786.
RX PUBMED: 8521822.
RA Hurlin P. J., Queva C., Koskinen P. J., Steingrimsson E., Ayer D. E., Copeland N. G., Jenkins N. A., Eisenman R. N.
RT Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
RL EMBO J. 14:5646-5659 (1995).
RN [11]; RE0014513.
RX PUBMED: 10557294.
RA Iritani B. M., Eisenman R. N.
RT c-Myc enhances protein synthesis and cell size during B lymphocyte development
RL Proc. Natl. Acad. Sci. USA 96:13180-13185 (1999).
RN [12]; RE0014549.
RX PUBMED: 6462227.
RA Stanton L. W., Fahrlander P. D., Tesser P. M., Marcu K. B.
RT Nucleotide sequence comparison of normal and translocated murine c-myc genes
RL Nature 310:423-425 (1984).
RN [13]; RE0014569.
RX PUBMED: 7991585.
RA Mueller J. R., Potter M., Janz S.
RT Differences in the molecular structure of c-myc-activating recombinations in murine plasmacytomas and precursor cells
RL Proc. Natl. Acad. Sci. USA 91:12066-12070 (1994).
RN [14]; RE0014588.
RX PUBMED: 6321164.
RA Bernard O., Cory S., Gerondakis S., Webb E., Adams J. M.
RT Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours
RL EMBO J. 2:2375-2383 (1983).
RN [15]; RE0046855.
RX PUBMED: 11058604.
RA Kumari D., Usdin K.
RT Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome
RL J. Biol. Chem. 276:4357-64 (2001).
RN [16]; RE0048184.
RX PUBMED: 15576399.
RA Hu M. C., Rosenblum N. D.
RT Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription.
RL Development 132:215-225 (2005).
RN [17]; RE0048481.
RX PUBMED: 15735755.
RA Cairo S., De Falco F., Pizzo M., Salomoni P., Pandolfi P. P., Meroni G.
RT PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.
RL Oncogene 24:2195-2203 (2005).
RN [18]; RE0055365.
RX PUBMED: 16924232.
RA Takada Y., Ichikawa H., Pataer A., Swisher S., Aggarwal B. B.
RT Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.
RL Oncogene 26:1201-1212 (2007).
RN [19]; RE0064539.
RX PUBMED: 18451303.
RA Thornton T. M., Pedraza-Alva G., Deng B., Wood C. D., Aronshtam A., Clements J. L., Sabio G., Davis R. J., Matthews D. E., Doble B., Rincon M.
RT Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.
RL Science 320:667-670 (2008).
RN [20]; RE0069431.
RX PUBMED: 18488021.
RA Zhao X., Heng J. I., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., Lasorella A.
RT The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
RL Nat. Cell Biol. 10:643-653 (2008).
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