TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00489 XX ID T00489 XX DT 21.10.1992 (created); ewi. DT 12.01.2010 (updated); jig. CO Copyright (C), QIAGEN. XX FA Max-isoform2 XX SY Max; Max protein; MAX-short; Max1; Myn (mouse); p21. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003958 MAX; HGNC: Max. XX CL C0012; bHLH-ZIP; XX SZ 151 AA; 17.2 kDa (cDNA) (calc.), 21kDa (SDS) [8] XX SQ MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATE SQ YIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGS SQ TISAFDGGSDSSSESEPEEPQSRKKLRMEAS XX SC edited Swiss-Prot #P61244-2 XX FT 2 2 Ser-phosphorylation by CKII [15]. FT 11 11 Ser-phosphorylation by CKII [15]. FT 15 66 PF00010; Helix-loop-helix DNA-binding domain. FT 15 66 PS50888; HLH. FT 20 71 SM00353; finulus. FT 90 151 replaced in delta Max by GESES [7]. FT 140 147 nuclear localization signal (NLS) [2]. XX SF several splice variants T00489, T01567 detected; SF Max homodimers and Myc/Max heterodimers exhibit different preferences for the trinucleotides flanking the core sequence (CACGTG) [5]; SF Max-isoform2 and Max2 also differ slightly in their DNA-binding specificity [5] [19]; SF heterodimers with either c-Myc or Mad exert higher DNA-binding affinity than Max homodimers unless the inhibiting CKII phosphorylation site is replaced by alanine [16] [20] [3]; SF heterodimerization requires the leucine zipper, but not homodimerization [12] [2]; SF DNA-binding by Max or Myc/Max induces bending towards the minor groove by 74-82 deg, but possibly in opposite orientations [6] [11]; SF belongs to group B HLH-proteins that bind to CACGTG motif in DNA which is due to certain residues in DNA-binding domain (His at pos. 19, Glu at pos. 23, Arg at pos. 27) [22] [23]; XX FF enhances c-Myc DNA-binding; FF in high concentrations: homodimers suppress c-Myc activities by competition [7] [9] [2]; FF after CKII phosphorylation, increases in on- and off-rates of DNA-binding of homo- and heterodimers have been found [15]; FF preferentially complexed with Mad instead of c-Myc upon myeloid differentiation [18]; XX IN T00140 c-Myc-isoform1; human, Homo sapiens. IN T00141 c-Myc; chick, Gallus gallus. IN T00142 c-Myc; rat, Rattus norvegicus. IN T00143 c-Myc; mouse, Mus musculus. IN T09007 c-Myc; mouse, Mus musculus. IN T02385 L-Myc-1(long form); human, Homo sapiens. IN T02388 L-Myc-1; clawed frog, Xenopus laevis. IN T02389 L-Myc-2; clawed frog, Xenopus laevis. IN T02387 L-Myc1; mouse, Mus musculus. IN T01565 Mad1; human, Homo sapiens. IN T02390 Mad1; mouse, Mus musculus. IN T02391 Mad3; mouse, Mus musculus. IN T02392 Mad4; mouse, Mus musculus. IN T00489 Max-isoform2; human, Homo sapiens. IN T01566 Max-isoform3; human, Homo sapiens. IN T01564 Mxi1; human, Homo sapiens. IN T01445 N-Myc; mouse, Mus musculus. IN T02379 N-Myc; human, Homo sapiens. IN T03268 Rox; human, Homo sapiens. XX MX M01034 V$EBOX_Q6_01. MX M00119 V$MAX_01. MX M01830 V$MAX_Q6. MX M00118 V$MYCMAX_01. MX M00123 V$MYCMAX_02. MX M00615 V$MYCMAX_03. MX M00322 V$MYCMAX_B. MX M00799 V$MYC_Q2. XX BS R02092. BS R02094. BS R04455. BS R04415. BS R04462. BS R04414. XX DR TRANSPATH: MO000019558. DR EMBL: BC003525; DR UniProtKB: P61244-2; XX RN [1]; RE0000477. RX PUBMED: 1935896. RA Wenzel A., Cziepluch C., Hamann U., Schuermann J., Schwab M. RT The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells RL EMBO J. 10:3703-3712 (1991). RN [2]; RE0000704. RX PUBMED: 1730412. RA Kato G. J., Lee W. M. F., Chen L., Dang C. V. RT Max: functional domains and interaction with c-Myc RL Genes Dev. 6:81-92 (1992). RN [3]; RE0000705. RX PUBMED: 1737614. RA Berberich S. J., Cole M. D. RT Casein kinase II inhibits the DNA-binding activity of Max homodimers but not Myc/Max heterodimers RL Genes Dev. 6:166-176 (1992). RN [4]; RE0002653. RX PUBMED: 2006410. RA Blackwood E. M., Eisenman R. N. RT Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc RL Science 251:1211-1217 (1991). RN [5]; RE0002937. RX PUBMED: 8265351. RA Solomon D. L. C., Amati B., Land H. RT Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers RL Nucleic Acids Res. 21:5372-5376 (1993). RN [6]; RE0003338. RX PUBMED: 1465398. RA Fisher D. E., Parent L. A., Sharp P. A. RT Myc/Max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove RL Proc. Natl. Acad. Sci. USA 89:11779-11783 (1992). RN [7]; RE0003350. RX PUBMED: 1566084. RA Maekelae T. P., Koskinen P. J., Vaestrik I., Alitalo K. RT Alternative forms of Max as enhancers or suppressors of Myc-Ras cotransformation RL Science 256:373-377 (1992). RN [8]; RE0003353. RX PUBMED: 1730411. RA Blackwood E. M., Luescher B., Eisenman R. N. RT Myc and Max associate in vivo RL Genes Dev. 6:71-80 (1992). RN [9]; RE0003361. RX PUBMED: 8425220. RA Amati B., Brooks M. W., Levy N., Littlewood T. D., Evan G. I., Land H. RT Oncogenic activity of the c-Myc protein requires dimerization with Max RL Cell 72:233-245 (1993). RN [10]; RE0003387. RX PUBMED: 1630816. RA Min S., Taparowsky E. J. RT v-Myc, but not Max, possesses domains that function in both transcription activation and cellular transformation RL Oncogene 7:1531-1540 (1992). RN [11]; RE0003396. RX PUBMED: 1323849. RA Wechsler D. S., Dang C. V. RT Opposite directions of DNA bending by c-Myc and Max RL Proc. Natl. Acad. Sci. USA 89:7635-7639 (1992). RN [12]; RE0003397. RX PUBMED: 1408152. RA Reddy C. D., Dasgupta P., Saikumar P., Dudek H., Rauscher III F. J., Reddy E. P. RT Mutational analysis of Max: role of basic, helix-loop-helix/leucine zipper domains in DNA binding, dimerization and regulation of Myc-mediated transcriptional activation RL Oncogene 7:2085-2092 (1992). RN [13]; RE0003398. RX PUBMED: 1557420. RA Wagner A. J., Le Beau M. M., Diaz M. O., Hay N. RT Expression, regulation, and chromosomal localization of the Max gene RL Proc. Natl. Acad. Sci. USA 89:3111-3115 (1992). RN [14]; RE0003399. RX PUBMED: 8262050. RA Fisher F., Crouch D. H., Jayaraman P. S., Clark W., Gillespie D. A. F., Goding C. R. RT Transcription activation by Myc and Max: flanking sequences target activation to a subset of CACGTG motifs in vivo RL EMBO J. 12:5075-5082 (1993). RN [15]; RE0003400. RX PUBMED: 8247525. RA Bousset K., Henriksson M., Luescher-Firzlaff J. M., Litchfield D. W., Luescher B. RT Identification of casein kinase II phosphorylation sites in Max: effects on DNA-binding kinetics of Max homo- and Myc/Max heterodimers RL Oncogene 8:3211-3220 (1993). RN [16]; RE0003401. RX PUBMED: 8425218. RA Ayer D. E., Kretzner L., Eisenman R. N. RT Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity RL Cell 72:211-222 (1993). RN [17]; RE0003402. RX PUBMED: 8425219. RA Zervos A. S., Gyuris J., Brent R. RT Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites RL Cell 72:223-232 (1993). RN [18]; RE0003403. RX PUBMED: 8224841. RA Ayer D. E., Eisenman R. N. RT A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation RL Genes Dev. 7:2110-2119 (1993). RN [19]; RE0003404. RX PUBMED: 8430110. RA Prochownik E. V., Antwerp M. E. RT Differential patterns of DNA binding by myc and max proteins RL Proc. Natl. Acad. Sci. USA 90:960-964 (1993). RN [20]; RE0005829. RX PUBMED: 7499403. RA Kohlhuber F., Hermeking H., Graessmann A., Eick D. RT Induction of apoptosis by the c-Myc helix-loop-helix/leucine zipper domain in mouse 3T3-L1 fibroblasts RL J. Biol. Chem. 270:28797-28805 (1995). RN [21]; RE0014442. RX PUBMED: 9184233. RA Meroni G., Reymond A., Alcalay M., Borsani G., Tanigami A., Tonlorenzi R., Nigro C. L., Messali S., Zollo M., Ledbetter D. H., Brent R., Ballabio A., Carrozzo R. RT Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor RL EMBO J. 16:2892-2906 (1997). RN [22]; RE0017805. RX PUBMED: 9860302. RA Meng X., Lu X., Li Z., Green E. D., Massa H., Trask B. J., Morris C. A., Keating M. T. RT Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes RL Hum. Genet. 103:590-599 (1998). RN [23]; RE0017817. RX PUBMED: 11073985. RA Billin A. N., Eilers A. L., Coulter K. L., Logan J. S., Ayer D. E. RT MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network RL Mol. Cell. Biol. 20:8845-8854 (2000). RN [24]; RE0047829. RX PUBMED: 16287840. RA Faiola F., Liu X., Lo S., Pan S., Zhang K., Lymar E., Farina A., Martinez E. RT Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. RL Mol. Cell. Biol. 25:10220-10234 (2005). RN [25]; RE0049739. RX PUBMED: 17217336. RA Faiola F., Wu Y. T., Pan S., Zhang K., Farina A., Martinez E. RT Max is acetylated by p300 at several nuclear localization residues. RL Biochem. J. 403:397-407 (2007). XX //